Contribution of narrow band imaging in delineation of laryngopharyngeal superficial cancer spread: a prospective study

Chabrillac, Emilien; Espinasse, Gaël; Lepage, Benoît; Uro‐Coste, Emmanuelle; Dupret‐Bories, Agnès; Bonnecaze, Guillaume de; Vergez, S.

doi:10.1007/s00405-020-06499-2

Cited by 3 publications

(15 citation statements)

References 28 publications

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“…A bi-centric prospective study performed by Chabrillac et al . 32 compared the results of laryngeal biopsy using white light and narrow-band imaging with direct laryngoscopy and biopsy. The narrow-band imaging result contributed to an upgrade of clinical T-staging in 4.8 per cent of patients, which had an impact on the type of treatment administered to one patient who was switched from exclusive radiotherapy to an organ preservation protocol.…”

Section: Discussionmentioning

confidence: 99%

A systematic review on efficacy, safety and cost-effectiveness of office-based laryngeal biopsy

et al. 2022

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Objective Laryngeal cancer is the second most prevalent head and neck malignancy in the USA. With recent advances in technology, this procedure is increasingly performed under local anaesthesia. This study aimed to identify the efficacy, safety and cost-effectiveness of laryngeal biopsy in out-patients by conducting a systematic review. Method A literature search was conducted using PubMed, Medline, Google Scholar and Embase over a 20-year period. Inclusion criteria were: studies performed on out-patient diagnostic biopsy procedures of the larynx. Exclusion criteria included all therapeutic procedures. The outcome measures were sensitivity and specificity, complication rate and cost-savings. Results Thirty-five studies were included in the analysis. The sensitivity and specificity varied from 60 to 100 per cent with a low complication rate and cost savings. Conclusion Office-based laryngeal biopsies are increasingly used in the diagnosis of laryngeal cancers, resulting in earlier diagnosis and commencement of treatment. The barrier to undertaking this procedure is low sensitivity.

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Section: Discussionmentioning

confidence: 99%

A systematic review on efficacy, safety and cost-effectiveness of office-based laryngeal biopsy

et al. 2022

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“…It is known that NBI can cause false positive assessments: false positive assessments occur in 7% to 14% of the cases described in the literature, especially in the early phase of the learning curve. 10,[39][40][41]…”

Section: Recurrencesmentioning

confidence: 99%

“…By identifying specific superficial vessel changes, (pre)malignant lesions can be easily detected 7,8,10 . Previous studies showed that the use of NBI enables an easier and more accurate determination of the exact resection margins 5,7,10‐15 …”

mentioning

confidence: 99%

“…[7][8][9] By identifying specific superficial vessel changes, (pre)malignant lesions can be easily detected. 7,8,10 Previous studies showed that the use of NBI enables an easier and more accurate determination of the exact resection margins. 5,7,[10][11][12][13][14][15] In 2017, our group published a retrospective study on the effect of the application of NBI preceding TOLS of early glottic cancer.…”

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confidence: 99%

“…NBI uses an optical filter to filter blue (415 nm) and green light (540 nm) which, due to their small wavelengths, only penetrate into the superficial layers of the mucosa and submucosa and highlight the superficial vascular structures located therein 7‐9 . By identifying specific superficial vessel changes, (pre)malignant lesions can be easily detected 7,8,10 . Previous studies showed that the use of NBI enables an easier and more accurate determination of the exact resection margins 5,7,10‐15 …”

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confidence: 99%

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Narrow‐Band Imaging in Transoral Laser Surgery for Early Glottic Cancer: A Randomized Controlled Trial

Zwakenberg

Westra

Halmos

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveAssessing whether the additional use of narrow‐band imaging (NBI) in transoral laser surgery (TOLS) for early laryngeal cancer improves clinical outcomes.Study DesignRandomized controlled trial, performed between September 2015 and November 2022.SettingA tertiary referral hospital in The Netherlands.MethodsTOLS was carried out in 113 patients. The procedure was performed with white light imaging (WLI, n = 56) alone, or combined with NBI (n = 57). Patients received frequent follow‐up laryngoscopy. Resection margin status, recurrence rate, and recurrence‐free survival at 12 months, 18 months, and after study termination (maximum 86 months) were analyzed.ResultsThirty‐one cases in the WLI group had a positive resection margin, versus 16 in the NBI group (p = .002). After 12 months, the recurrence‐free survival was 92%: 87% for WLI versus 96% for NBI, p = .07. The recurrence rate was 7/56 (13%) for WLI, versus 2/57 (4%) for NBI, p = .09. After 18 months, the recurrence‐free survival was 84% for WLI versus 96% for NBI, p = .02. The recurrence rate was 9/56 (16%) for WLI, versus 2/57 (4%) for NBI, p = .02. After study termination, the recurrence‐free survival was 71% for WLI versus 83% for the NBI group (p = .08). The recurrence rate was 16/56 for WLI, versus 10/57 for NBI (p = .16).ConclusionThe additional use of NBI during TOLS significantly decreased the number of positive resection margins. Although not statistically significant at all time points, patients treated with NBI‐supported TOLS showed a lower recurrence rate and better recurrence‐free survival. Further studies in larger patient groups are needed to confirm these results.

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Narrow band imaging reveals field cancerisation undetected by conventional white light: Optical diagnosis versus histopathology

Westra,

Zwakenberg,

Halmos

et al. 2024

Clinical Otolaryngology

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ObjectiveTo assess whether narrow band imaging (NBI) detects fields of cancerisation around suspicious lesions in the upper aerodigestive tract, which were undetected by white light imaging (WLI).MethodsIn 96 patients with laryngeal and pharyngeal lesions suspicious for malignancy, 206 biopsies were taken during laryngoscopy: 96 biopsies of suspicious lesions detected by both WLI and NBI (WLI+/NBI+), 60 biopsies adjacent mucosa only suspicious with NBI (WLI‐/NBI+), and 46 biopsies of NBI and WLI unsuspicious mucosa (WLI‐/NBI‐) as negative controls. Optical diagnosis according to the Ni‐classification was compared with histopathology.ResultsSigns of (pre)malignancy were found in 88% of WLI+/NBI+ biopsies, 32% of WLI‐/NBI+ biopsies and 0% in WLI‐/NBI‐ (p < .001). In 58% of the WLI‐/NBI+ mucosa any form of dysplasia or carcinoma was detected.ConclusionThe use of additional NBI led to the detection of (pre)malignancy in 32% of the cases, that would have otherwise remained undetected with WLI alone. This highlights the potential of NBI as a valuable adjunct to WLI in the identification of suspicious lesions in the upper aerodigestive tract.

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Contribution of narrow band imaging in delineation of laryngopharyngeal superficial cancer spread: a prospective study

Cited by 3 publications

References 28 publications

A systematic review on efficacy, safety and cost-effectiveness of office-based laryngeal biopsy

A systematic review on efficacy, safety and cost-effectiveness of office-based laryngeal biopsy

Narrow‐Band Imaging in Transoral Laser Surgery for Early Glottic Cancer: A Randomized Controlled Trial

Narrow band imaging reveals field cancerisation undetected by conventional white light: Optical diagnosis versus histopathology

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