Contribution of Mitochondria to Insulin Secretion by Various Secretagogues

Ježek, Petr; Holendová, Blanka; Jabůrek, Martin; Dlasková, Andrea; Plecitá–Hlavatá, Lydie

doi:10.1089/ars.2021.0113

Cited by 19 publications

(15 citation statements)

References 300 publications

(602 reference statements)

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“…These pan-stimulus enabling proteins were ADP-Ribosylation Factor GTPase 6 Interacting Protein 6 (ARL6IP6), solute carrier family 25 member 4 (SLC25A4), and secretory carrier membrane protein 4 (SCAMP4). These findings highlight the critical role of mitochondria in nutrient-and depolarization-stimulated insulin secretion 43 .…”

Section: Associations Between Individual Proteins Donor Data and Isle...mentioning

confidence: 68%

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease

Kolic

Sun

Cen

et al. 2023

Preprint

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Population level variation and molecular mechanisms behind insulin secretion in response to carbohydrate, protein, and fat remain uncharacterized despite ramifications for personalized nutrition.We now define prototypical insulin secretion dynamics in response to the three macronutrients in islets from 140 cadaveric donors, including those diagnosed with type 2 diabetes. We leverage the insulin response heterogeneity and use transcriptomics and proteomics to identify molecular pathways of specific nutrient responsiveness. Surprisingly, we find robust insulin secretion to fatty acid stimulus in ~8% of donors, challenging the idea that fat has negligible effects on insulin release. By comparing human islets to human embryonic stem cell-derived islet clusters, we show that, unlike glucose-responsiveness, fat hyper-responsiveness is equivalent and may be a hallmark of functionally immature cells. Our study represents the first comparison of dynamic responses to nutrients and multi-omics analysis in human insulin secreting cells. Responses of different people's islets to carbohydrate, protein, and fat lay the groundwork for personalized nutrition.

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Section: Associations Between Individual Proteins Donor Data and Isle...mentioning

confidence: 68%

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease

Kolic

Sun

Cen

et al. 2023

Preprint

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show abstract

“…This sequence of events triggers insulin exocytosis. Along with glucose, the gut-derived incretin hormones, islet-derived adenosine, and the nervous system (secreting adrenaline and acetylcholine) have a relevant modulatory function on insulin secretion [ 34 , 35 , 36 , 37 , 38 , 39 ]. However, in type 1 diabetes, the insulin-secretory function of β-cells markedly deteriorates, leading to insulin deficiency and the resulting hyperglycemia.…”

Section: Anti-diabetic Effects Of Baicalinmentioning

confidence: 99%

The Anti-Diabetic Potential of Baicalin: Evidence from Rodent Studies

Szkudelski,

Szkudelska

2023

IJMS

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Baicalin is a biologically active flavonoid compound that benefits the organism in various pathological conditions. Rodent studies have shown that this compound effectively alleviates diabetes-related disturbances in models of type 1 and type 2 diabetes. Baicalin supplementation limited hyperglycemia and improved insulin sensitivity. The anti-diabetic effects of baicalin covered the main insulin-sensitive tissues, i.e., the skeletal muscle, the adipose tissue, and the liver. In the muscle tissue, baicalin limited lipid accumulation and improved glucose transport. Baicalin therapy was associated with diminished adipose tissue content and increased mitochondrial biogenesis. Hepatic lipid accumulation and glucose output were also decreased as a result of baicalin supplementation. The molecular mechanism of the anti-diabetic action of this compound is pleiotropic and is associated with changes in the expression/action of pivotal enzymes and signaling molecules. Baicalin positively affected, among others, the tissue insulin receptor, glucose transporter, AMP-activated protein kinase, protein kinase B, carnitine palmitoyltransferase, acetyl-CoA carboxylase, and fatty acid synthase. Moreover, this compound ameliorated diabetes-related oxidative and inflammatory stress and reduced epigenetic modifications. Importantly, baicalin supplementation at the effective doses did not induce any side effects. Results of rodent studies imply that baicalin may be tested as an anti-diabetic agent in humans.

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“…That is why pharmacological inhibition of LDH increases NADH levels and stimulates mitochondrial shuttles which ultimately leads to insulin secretion. [ 11 , 12 ]…”

Section: Metabolomics In Insulin Secretion and Effectmentioning

confidence: 99%

Diabetes and diabesity in the view of proteomics, drug, and plant-derived remedies

Haeri

2023

J Res Med Sci

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Diabetes and obesity are highly prevalent in the world. Proteomics is a promising approach to better understanding enzymes, proteins, and signaling molecules involved in diabetes processes which help recognize the basis of the disease better and find suitable new treatments. This study aimed to summarize the molecular mechanisms from the beginning of insulin secretion in response to stimuli to the pathology of the insulin signaling pathway and, finally, the mechanisms of drugs/chemicals remedies that affect this process. The titles and subtitles of this process were determined, and then for each of them, the articles searched in PubMed and ScienceDirect were used. This review article starts the discussion with the molecular basis of insulin biosynthesis, secretion, insulin’s mechanism of action, and molecular aspect of diabetes and diabesity (a new term showing the relation between diabetes and obesity) and ends with the drug and plant-derived intervention for hyperglycemia.

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Contribution of Mitochondria to Insulin Secretion by Various Secretagogues

Cited by 19 publications

References 300 publications

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease

The Anti-Diabetic Potential of Baicalin: Evidence from Rodent Studies

Diabetes and diabesity in the view of proteomics, drug, and plant-derived remedies

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