Contribution of miRNAs and lncRNAs in osteogenesis and related disorders

Ghafouri‐Fard, Soudeh; Abak, Atefe; Avval, Shiva Tavakkoli; Rahmani, Shayan; Shoorei, Hamed; Taheri, Mohammad; Samadian, Mohammad

doi:10.1016/j.biopha.2021.111942

Cited by 26 publications

(16 citation statements)

References 159 publications

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“…Furthermore, the same group have found in the literature that both miRs and lncRNAs can regulate bone development processes including osteogenesis. Both intramembranous and endochondrial ossification of osteogenesis were observed ( Ghafouri-Fard et al, 2021b ). miRs were found to exert their actions through both Wnt/β-catenin and TGF-β/BMP pathways whereas lncRNAs worked as molecular sponge for binding miRs to directly affect these pathways and osteogenic transcription factors.…”

Section: Pathogenesis Of Osteoporosis and Osteogenesis In As Patientsmentioning

confidence: 99%

The Potential Role of Genetics, Environmental Factors, and Gut Dysbiosis in the Aberrant Non-Coding RNA Expression to Mediate Inflammation and Osteoclastogenic/Osteogenic Differentiation in Ankylosing Spondylitis

Liao

Tsai

Lai

et al. 2022

Front. Cell Dev. Biol.

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Ankylosing spondylitis (AS) or radiographic axial spondyloarthritis is a chronic immune-mediated rheumatic disorder characterized by the inflammation in the axial skeleton, peripheral joints, and soft tissues (enthesis, fascia, and ligament). In addition, the extra-skeletal complications including anterior uveitis, interstitial lung diseases and aortitis are found. The pathogenesis of AS implicates an intricate interaction among HLA (HLA-B27) and non-HLA loci [endoplasmic reticulum aminopeptidase 1 (ERAP1), and interleukin-23 receptor (IL23R), gut dysbiosis, immune plasticity, and numerous environmental factors (infections, heavy metals, stress, cigarette smoking, etc.) The latter multiple non-genetic factors may exert a powerful stress on epigenetic regulations. These epigenetic regulations of gene expression contain DNA methylation/demethylation, histone modifications and aberrant non-coding RNAs (ncRNAs) expression, leading to inflammation and immune dysfunctions. In the present review, we shall discuss these contributory factors that are involved in AS pathogenesis, especially the aberrant ncRNA expression and its effects on the proinflammatory cytokine productions (TNF-α, IL-17 and IL-23), T cell skewing to Th1/Th17, and osteoclastogenic/osteogenic differentiation. Finally, some potential investigatory approaches are raised for solving the puzzles in AS pathogenesis.

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Section: Pathogenesis Of Osteoporosis and Osteogenesis In As Patientsmentioning

confidence: 99%

The Potential Role of Genetics, Environmental Factors, and Gut Dysbiosis in the Aberrant Non-Coding RNA Expression to Mediate Inflammation and Osteoclastogenic/Osteogenic Differentiation in Ankylosing Spondylitis

Liao

Tsai

Lai

et al. 2022

Front. Cell Dev. Biol.

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“…LncRNAs are known to function as competing endogenous RNAs, binding to miRNAs responses to effectively sequester miRNAs, thereby regulating biological processes such as osteogenesis [ 43 ]. This feature of lncRNAs effectively prevents miRNAs from binding to their target mRNA molecules, the translation of which they are usually able to suppress in a highly specific manner by binding to their 3′-UTR.…”

Section: Lncrnas and Bmps Signaling Pathwaymentioning

confidence: 99%

“…The lncRNA/miRNA/mRNA axis has been reported to exist widely in various disease contexts (e.g. tumors), but there is limited research on how this axis functions in the context of osteogenic differentiation, making the study of these functions and their underlying molecular mechanisms an important research area [ 43 , 44 ]. Li et al found that BMP-9 stimulation could expedite peak expression of HOX transcript antisense RNA (HOTAIR) [ 45 ].…”

Section: Lncrnas and Bmps Signaling Pathwaymentioning

confidence: 99%

Functions of the bone morphogenetic protein signaling pathway through non-coding RNAs

Мухаметов

Lyulin²,

Borzunov³

et al. 2022

Non-coding RNA Research

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“…Remarkably, an interesting ncRNA-based mechanism that may have a potential therapeutic role in bone diseases is the sponging effect of lncRNAs against miRNAs [ 166 ]. The LEF1-AS1/miR-24-3p, MCF2L-AS1/miR-33a, and MALAT1/miR-30 are some examples of these interactions that occur during osteogenesis [ 167 ]. Other intriguing lncRNA-miRNA interactions with promising clinical roles that were discussed within this review are MSC-AS1/miR-140-5p (osteoporosis) [ 59 ], SNHG16/miR-205 (osteosarcoma) [ 79 ], and FAM83H-AS1/miR-541-3p (osteomyelitis) [ 144 ].…”

Section: Future Prospectsmentioning

confidence: 99%

The Emerging Role of MicroRNAs in Bone Diseases and Their Therapeutic Potential

et al. 2021

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MicroRNAs (miRNAs) are a class of small (20–24 nucleotides), highly conserved, non-coding RNA molecules whose main function is the post-transcriptional regulation of gene expression through sequence-specific manners, such as mRNA degradation or translational repression. Since these key regulatory molecules are implicated in several biological processes, their altered expression affects the preservation of cellular homeostasis and leads to the development of a wide range of pathologies. Over the last few years, relevant investigations have elucidated that miRNAs participate in different stages of bone growth and development. Moreover, the abnormal expression of these RNA molecules in bone cells and tissues has been significantly associated with the progression of numerous bone diseases, including osteoporosis, osteosarcoma, osteonecrosis and bone metastasis, among others. In fact, miRNAs regulate multiple pathological mechanisms, including altering either osteogenic or osteoblast differentiation, metastasis, osteosarcoma cell proliferation, and bone loss. Therefore, in this present review, aiming to impulse the research arena of the biological implications of miRNA transcriptome in bone diseases and to explore their potentiality as a theragnostic target, we summarize the recent findings associated with the clinical significance of miRNAs in these ailments.

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Contribution of miRNAs and lncRNAs in osteogenesis and related disorders

Cited by 26 publications

References 159 publications

The Potential Role of Genetics, Environmental Factors, and Gut Dysbiosis in the Aberrant Non-Coding RNA Expression to Mediate Inflammation and Osteoclastogenic/Osteogenic Differentiation in Ankylosing Spondylitis

The Potential Role of Genetics, Environmental Factors, and Gut Dysbiosis in the Aberrant Non-Coding RNA Expression to Mediate Inflammation and Osteoclastogenic/Osteogenic Differentiation in Ankylosing Spondylitis

Functions of the bone morphogenetic protein signaling pathway through non-coding RNAs

The Emerging Role of MicroRNAs in Bone Diseases and Their Therapeutic Potential

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