Contribution of Matrix Metalloproteinase-2 Genotypes to Taiwan Pterygium Risk

HU, PEI-SHIN; HSIA, NING-YI; WANG, ZHI-HONG; CHEN, HUNG-CHIH; HSIA, TE-CHUN; LIN, MENG-LIANG; WANG, YUN-CHI; CHANG, WEN-SHIN; BAU, DA-TIAN; TSAI, CHIA-WEN

doi:10.21873/invivo.13472

In Vivo

2024

DOI: 10.21873/invivo.13472

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Contribution of Matrix Metalloproteinase-2 Genotypes to Taiwan Pterygium Risk

PEI-SHIN HU,

NING-YI HSIA,

ZHI-HONG WANG

et al.

Abstract: Background/Aim: In the literature, the studies about the role of matrix metalloproteinase-2 (MMP-2) in pterygium diagnosis are mainly based on its protein expression. The role of MMP-2 variants has never been examined. The aim of this study was to examine the association of MMP-2 genotypes with pterygium risk. Materials and Methods: MMP-2 rs243865 and rs2285053 were genotyped in 140 pterygium cases and 280 nonpterygium controls by typical polymerase chain reactionrestriction fragment length polymorphism (PCR-R… Show more

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Contribution of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 to Upper Tract Urothelial Cancer Risk in Taiwan

Wang,

Ma,

Chang

et al. 2024

Life

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Matrix metalloproteinase (MMP)-2 and -9, which degrade type IV collagen, are linked to cancer invasion and metastasis. Gene polymorphisms in MMP-2 and MMP-9 can influence their function, impacting cancer development and progression. This study analyzed the association between polymorphisms MMP-2 rs243865 (C-1306T), rs2285053 (C-735T), and MMP-9 rs3918242 (C-1562T) with serum concentrations of these enzymes in upper tract urothelial cancer (UTUC) patients. We conducted a case–control study with 218 UTUC patients and 580 healthy individuals in Taiwan. Genotyping was performed using PCR/RFLP on DNA from blood samples, and MMP-2 and MMP-9 serum levels and mRNA expressions in 30 UTUC patients were measured using ELISA and real-time PCR. Statistical analysis showed that MMP-2 rs2285053 and MMP-9 rs3918242 genotypes were differently distributed between UTUC patients and controls (p = 0.0199 and 0.0020). The MMP-2 rs2285053 TT genotype was associated with higher UTUC risk compared to the CC genotype (OR = 2.20, p = 0.0190). Similarly, MMP-9 rs3918242 CT and TT genotypes were linked to increased UTUC risk (OR = 1.51 and 2.92, p = 0.0272 and 0.0054). In UTUC patients, TT carriers of MMP-2 rs2285053 and MMP-9 rs3918242 showed higher mRNA and protein levels (p < 0.01). These findings suggest that MMP-2 rs2285053 and MMP-9 rs3918242 genotypes are significant markers for UTUC risk and metastasis in Taiwan.

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Contribution of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 to Upper Tract Urothelial Cancer Risk in Taiwan

Wang,

Ma,

Chang

et al. 2024

Life

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show abstract

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Contribution of Matrix Metalloproteinase-2 Genotypes to Taiwan Pterygium Risk

Cited by 1 publication

References 30 publications

Contribution of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 to Upper Tract Urothelial Cancer Risk in Taiwan

Contribution of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 to Upper Tract Urothelial Cancer Risk in Taiwan

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