Contribution of ¹⁸F-FDG PET/CT in the Differential Diagnosis of Pulmonary Hamartomas and Pulmonary Carcinoids

Abstract

Objectives: This study aimed to evaluate 18 fluorine-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography/computed tomography (PET/CT) findings in the differential diagnosis of pulmonary carcinoids and pulmonary hamartomas. Methods: 18 F-FDG PET/CT findings of 34 patients with pulmonary carcinoids (12 atypical, 22 typical) and 32 patients with pulmonary hamartomas were retrospectively evaluated. Both mean diameter and mean maximum standardized uptake value (SUV max ) of hamartomas and carcinoids were compared by Mann-Whitney U and Kruskall-Wallis H tests. Results: The mean longest diameter of atypical carcinoids (3.5±1.7 cm) was higher than that of hamartomas (2.1±1 cm) (p=0.038). No significant difference was found between the mean diameter of typical carcinoids and mean diameter of hamartomas (p=0.128). The mean SUV max of atypical carcinoids (5.97±3.7) and typical carcinoids (4.22±1.7) were higher than those of hamartomas (1.65±0.9) (p=0.002 and p=0.003, respectively). There were collapse/consolidation in 55.8%, bronchiectasis or mucoid impaction in 47%, and air trapping in 14.7% in the peripheral parenchyma of the 34 carcinoids. Collapse/consolidation was detected in a patient with endobronchial hamartoma, and other finding was not found in the parenchyma around hamartomas. Conclusion: The 18 F-FDG uptake of pulmonary carcinoids can vary from minimal to intense. 18 F-FDG uptake can be seen in pulmonary hamartomas. However, the mean SUV max of atypical carcinoids and typical carcinoids were higher compared to hamartomas. Pulmonary carcinoid must be suspected in cases with accompanying bronchial obstruction findings in the periphery of the mass.

Diagnosis value of 18 F-Fluoro-D-glucose positron emission tomography-computed tomography in pulmonary hamartoma

“…Characteristics of the screened studies A total of 219 patients con rmed to have PH and had undergone PET-CT were included in this study. A total of 10 eligible publications were retrieved (3,4,(11)(12)(13)(14)(15)(16)(17)(18) , which involved 196 patients. And the rest 23 of the collection were patients from the First A liated Hospital of Soochow University.…”

“…Mean diameter and mean SUVmax analyzed in literature A total of 165 eligible cases were included in this analysis, based on data from 4 articles (11)(12)(13)(14) . All these cases were diagnosed PH pathologically.…”

“…The cut-off value we concluded based on our cases A total of 32 eligible PH patients were included in this analysis, including 9 patients from literatures (3,4,(12)(13)(14)(15)(16)(17)(18) and 23 in our hospital. In addition, 29 lung cancer patients with SUVmax value in our hospital were collected to draw the ROC curve.…”

Diagnosis value of 18F-Fluoro-d-glucose positron emission tomography-computed tomography in pulmonary hamartoma: a retrospective study and systematic review

“…A total of 216 patients confirmed to have PH and had undergone PET-CT were included in this study. A total of 10 eligible publications were retrieved [3,4,[11][12][13][14][15][16][17][18], which involved 196 patients. And the rest 20 cases of the collection were patients from the First Affiliated Hospital of Soochow University.…”

“…A total of 165 eligible cases were included in this analysis, based on data from 4 articles [11][12][13][14]. All these cases were diagnosed PH pathologically.…”