“…In autoimmune-mediated skin diseases such as psoriasis, KCs, DCs, macrophages, neutrophils, and T cells assume a pivotal role ( 80 , 89 ). KCs are primarily situated in the outermost layer of the epidermis, forming the stratum corneum, a fundamental component of the epidermis ( 90 ) ( 91 ). They represent the innate immune constituents within the skin’s immune system, actively combating external pathogens and engaging in immune and inflammatory responses ( 18 , 92 ).…”