Contribution of katG, ahpC and inhA mutations to the detection of isoniazid-resistant Mycobacterium tuberculosis isolates from Lebanon and Syria

Dabboussi, Fouad; Ismail, Bassel; Rahmo, Abdulkader; Hamzé, Monzer

doi:10.1016/j.ijmyco.2014.11.006

Cited by 3 publications

(1 citation statement)

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“…The proportion of TB patients who were Lebanese nationals declined from 66.7% to 49.4% between 2010 and 2014, while the proportion who were Syrian refugees increased 10-fold, from 1.6% to 16% in the same period. In 2013, the Lebanese NTP noted that 100 cases of TB were notified among Syrian refugees, including three cases of MDR TB (Dabboussi et al, 2015). In Jordan, TB case notification rates among Syrian refugees were almost 40% higher than among local populations; however, the numbers were small with around 74 cases detected in a 12-month period (Cookson et al, 2015;WHO, 2019).…”

Section: Syrian Refugees In Lebanon and Jordanmentioning

confidence: 99%

The challenges of tuberculosis control in protracted conflict: The case of Syria

Abbara

Almalla

AlMasri

et al. 2020

International Journal of Infectious Diseases

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Objectives: Syria's protracted conflict has resulted in ideal conditions for the transmission of tuberculosis (TB) and the cultivation of drug-resistant strains. This paper compares TB control in Syria before and after the conflict using available data, examines the barriers posed by protracted conflict and those specific to Syria, and discusses what measures can be taken to address the control of TB in Syria. Results: Forced mass displacement and systematic violations of humanitarian law have resulted in overcrowding and the destruction of key infrastructure, leading to an increased risk of both drugsensitive and resistant TB, while restricting the ability to diagnose, trace contacts, treat, and follow-up. Pre-conflict, TB in Syria was officially reported at 22 per 100 000 population; the official figure for 2017 of 19 per 100 000 is likely a vast underestimate given the challenges and barriers to case detection. Limited diagnostics also affect the diagnosis of multidrug-and rifampicin-resistant TB, reported as comprising 8.8% of new diagnoses in 2017. Conclusions: The control of TB in Syria requires a multipronged, tailored, and pragmatic approach to improve timely diagnosis, increase detection, stop transmission, and mitigate the risk of drug resistance. Solutions must also consider vulnerable populations such as imprisoned and besieged communities where the risk of drug resistance is particularly high, and must recognize the limitations of national programming. Strengthening capacity to control TB in Syria with particular attention to these factors will positively impact other parallel conditions; this is key as attention turns to post-conflict reconstruction.

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Section: Syrian Refugees In Lebanon and Jordanmentioning

confidence: 99%

The challenges of tuberculosis control in protracted conflict: The case of Syria

Abbara

Almalla

AlMasri

et al. 2020

International Journal of Infectious Diseases

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Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis

Unissa

Subbian

Hanna

et al. 2016

Infection, Genetics and Evolution

181

131

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Design, challenge, and promise of stimuli-responsive nanoantibiotics

Edson

Kwon

2016

Nano Convergence

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Over the past few years, there have been calls for novel antimicrobials to combat the rise of drug-resistant bacteria. While some promising new discoveries have met this call, it is not nearly enough. The major problem is that although these new promising antimicrobials serve as a short-term solution, they lack the potential to provide a long-term solution. The conventional method of creating new antibiotics relies heavily on the discovery of an antimicrobial compound from another microbe. This paradigm of development is flawed due to the fact that microbes can easily transfer a resistant mechanism if faced with an environmental pressure. Furthermore, there has been some evidence to indicate that the environment of the microbe can provide a hint as to their virulence. Because of this, the use of materials with antimicrobial properties has been garnering interest. Nanoantibiotics, (nAbts), provide a new way to circumvent the current paradigm of antimicrobial discovery and presents a novel mechanism of attack not found in microbes yet; which may lead to a longer-term solution against drug-resistance formation. This allows for environment-specific activation and efficacy of the nAbts but may also open up and create new design methods for various applications. These nAbts provide promise, but there is still ample work to be done in their development. This review looks at possible ways of improving and optimizing nAbts by making them stimuli-responsive, then consider the challenges ahead, and industrial applications.Graphical abstractA graphic detailing how the current paradigm of antibiotic discovery can be circumvented by the use of nanoantibiotics

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Contribution of katG, ahpC and inhA mutations to the detection of isoniazid-resistant Mycobacterium tuberculosis isolates from Lebanon and Syria

Cited by 3 publications

References 0 publications

The challenges of tuberculosis control in protracted conflict: The case of Syria

The challenges of tuberculosis control in protracted conflict: The case of Syria

Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis

Design, challenge, and promise of stimuli-responsive nanoantibiotics

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