Contribution of infralimbic cortex in the cardiovascular response to acute stress

Müller-Ribeiro, Flávia Camargos de Figueirêdo; Zaretsky, Dmitry V.; Zaretskaia, Maria V.; Santos, Robson A.S.; DiMicco, Joseph A.; Fontes, Marco Antônio Peliky

doi:10.1152/ajpregu.00573.2011

Cited by 43 publications

(38 citation statements)

References 52 publications

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“…It is therefore possible that the mPFC mediates the differential effects of controllability on the diurnal HR response to stress. Consistent with this idea, the mPFC has been reported to be involved in stress-evoked heart rate responses [57, 58, 59, 60] and the baroreflex parasympathetic component of the cardiac response to stressor exposure [61, 62, 63]. The mPFC can be subdivided into several distinct regions including the prelimbic (PL) and the infralimbic (IL) cortex comprising the ventral mPFC [64, 65, 66], which when stimulated produces greater cardiovascular effects than other areas of the mPFC [64, 67].…”

Section: Discussionmentioning

confidence: 81%

Effects of stressor controllability on diurnal physiological rhythms

Thompson

Christianson

Maslanik

et al. 2013

Physiology & Behavior

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Disruptions in circadian and diurnal rhythms are associated with stress-related psychiatric disorders and stressor exposure can disrupt these rhythms. The controllability of the stressor can modulate various behavioral and neurochemical responses to stress. Uncontrollable, but not controllable, stress produces behaviors in rats that resemble symptoms of anxiety and depression. Whether acute stress-induced disruptions in physiological rhythms are sensitive to controllability of the stressor, however, remains unknown. To examine the role of controllability in diurnal rhythm disruption, adult male Sprague Dawley rats were implanted with Data Sciences International (DSI) biotelemetry devices. Real-time measurements were obtained before, during and after exposure to a controllable or yoked uncontrollable stressor. Controllable and uncontrollable stress equally disrupted diurnal rhythms of locomotor activity and body temperature but not heart rate. The diurnal heart rate the day following stressor exposure was flattened to a greater extent and was significantly higher in rats with control over stress suggesting a relationship between stressor controllability and the heart rate response. Our results are consistent with the conclusion that acute stress-induced disruptions in diurnal physiological rhythms likely contribute little to the behavioral and affective consequences of stress that are sensitive to stressor controllability.

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Section: Discussionmentioning

confidence: 81%

Effects of stressor controllability on diurnal physiological rhythms

Thompson

Christianson

Maslanik

et al. 2013

Physiology & Behavior

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“…The medial prefrontal cortex (mPFC) is involved in cardiovascular modulation (Fernandes et al 2003; Fernandes et al 2007; Tavares et al 2004), metabolic and behavioral control, particularly in response to stressful stimuli (McKlveen et al 2013; Muller-Ribeiro et al 2012). Both the infralimbic and prelimbic portions of the ventral mPFC are involved in cardiovascular and behavioral responses to stressful stimuli, and contain a particular abundance of AT2R-eGFP neurons.…”

Section: Discussionmentioning

confidence: 99%

Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system

et al. 2014

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Angiotensin-II acts at its type-1 receptor (AT1R) in the brain to regulate body fluid homeostasis, sympathetic outflow and blood pressure. However, the role of the angiotensin type-2 receptor (AT2R) in the neural control of these processes has received far less attention, largely because of limited ability to effectively localize these receptors at a cellular level in the brain. The present studies combine the use of a bacterial artificial chromosome transgenic AT2R-enhanced green fluorescent protein (eGFP) reporter mouse with recent advances in in situ hybridization (ISH) to circumvent this obstacle. Dual immunohistochemistry (IHC)/ ISH studies conducted in AT2R-eGFP reporter mice found that eGFP and AT2R mRNA were highly co-localized within the brain. Qualitative analysis of eGFP immunoreactivity in the brain then revealed localization to neurons within nuclei that regulate blood pressure, metabolism and fluid balance (e.g., NTS and median preoptic nucleus [MnPO]), as well as limbic and cortical areas known to impact stress responding and mood. Subsequently, dual IHC/ISH studies uncovered the phenotype of specific populations of AT2R-eGFP cells. For example, within the NTS, AT2R-eGFP neurons primarily express glutamic acid decarboxylase-1 (80.3 ± 2.8 %), while a smaller subset express vesicular glutamate transporter-2 (18.2 ± 2.9 %) or AT1R (8.7 ± 1.0 %). No co-localization was observed with tyrosine hydroxylase in the NTS. Although AT2R-eGFP neurons were not observed within the paraventricular nucleus of the hypothalamus (PVN), eGFP- immunoreactivity is localized to efferents terminating in the PVN and within GABAergic neurons surrounding this nucleus. These studies demonstrate that central AT2R are positioned to regulate blood pressure, metabolism and stress responses.

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“…For example, stimulating the SA in animals appears to have parasympathetic-type effects, leading to reductions in heart rate and blood pressure (114–116). Likewise, the VMPFC has been shown to play a role in parasympathetic responding (74) and stimulating the VMPFC in rats can suppress cardiovascular responses to stress (152). …”

Section: Discussionmentioning

confidence: 99%

An Empirical Review of the Neural Underpinnings of Receiving and Giving Social Support

Eisenberger

2013

Psychosomatic Medicine

166

117

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Decades of research have demonstrated strong links between social ties and health. Although considerable evidence has shown that social support can attenuate downstream physiological stress responses that are relevant to health, the neurocognitive mechanisms that translate perceptions of social ties into altered physiological responses are still not fully understood. This review integrates research from social and affective neuroscience to illuminate some of the neural mechanisms involved in social support processes, which may further our understanding of the ways in which social support influence health. This review focuses on two types of social support that have been shown to relate to health: receiving and giving social support. As the neural basis of receiving support, this article reviews the hypothesis that receiving support may benefit health through the activation of neural regions that respond to safety and inhibit threat-related neural and physiological responding. This article will then review neuroimaging studies in which subjects were primed with or received support during a negative experience as well as studies in which self-reports of perceived support were correlated with neural responses to a negative experience. As the neural basis of giving support, this article reviews the hypothesis that neural regions involved in maternal caregiving behavior may be critical for the health benefits of support-giving through the inhibition of threat-related neural and physiological responding. Neuroimaging studies in which subjects provided support to others or engaged in other related forms of prosocial behavior will then be reviewed. Implications of these findings for furthering our understanding of the relationships between social support and health are discussed.

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Contribution of infralimbic cortex in the cardiovascular response to acute stress

Cited by 43 publications

References 52 publications

Effects of stressor controllability on diurnal physiological rhythms

Effects of stressor controllability on diurnal physiological rhythms

Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system

An Empirical Review of the Neural Underpinnings of Receiving and Giving Social Support

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