Contribution of immunocytochemistry to the diagnosis of usual and unusual lymphoma cases

Das, Dilip K.

doi:10.4103/joc.joc_42_18

Cited by 17 publications

(12 citation statements)

References 31 publications

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“…Immunostaining can help with this distinction, since nonkeratinizing squamous cell carcinomas are positive for CK 5/6, p63 and p40 [1], whereas the cytokeratin pattern in NEC is often in the form of dots [45]. Regarding adenoid cystic carcinoma, although there is controversy concerning the immunostaining of p63 and p40, the solid pattern is negative for p40 [46] and still positive for C-kit [47,48], while non-Hodgkin lymphomas are positive for LCA and lymphocyte cell markers [49]. In the absence of these tumors, metastasis must be considered, but the presence of neuroendocrine differentiation markers is essential for a more conclusive diagnosis [50].…”

Section: Discussionmentioning

confidence: 99%

Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review

Schuch

Schmidt

Zigmundo

et al. 2021

Head and Neck Pathol

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The aim of the present study was to integrate the available data published in the literature on oral and maxillofacial neuroendocrine carcinomas concerning the demographic, clinical and histopathological features of this condition. An electronic search with no publication date restriction was undertaken in April 2021 in four databases. Eligibility criteria included reports published in English having enough data to confirm a definite diagnosis, always showing a neuroendocrine marker. Cases originating in the oropharynx, including base of the tongue and tonsils, were excluded. Outcomes were evaluated by the Kaplan-Meier method along with Cox regression. Twenty-five articles (29 cases) from nine different countries were detected. Mean patient age was 56.3 (± 17.5) years, with a slight male predilection. Symptomatology was present in 72.2% of informed cases. Regarding clinical presentation, a non-ulcerated nodule located in the gingiva with a mean size of 3.4 (± 2.0) cm was most frequently reported. Concomitant metastasis was identified in seven individuals. Histopathologically, most neoplasms were of the small cell type, and immunohistochemistry for both epithelial and neuroendocrine differentiation was used in 65.5% cases. Radical surgery was the treatment of choice in almost all cases, with or without adjuvant therapy. Mean follow-up was 20.5 (± 21.2) months, and only four patients developed recurrences. Eleven (44.0%) individuals died due to the disease. Ulcerated lesions were a prognostic factor. This study provides knowledge that can assist surgeons, oncologists, and oral and maxillofacial pathologists with the diagnosis and management of neuroendocrine carcinomas. Our findings demonstrated that the long-term prognosis of this lesion continues to be poor.

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Section: Discussionmentioning

confidence: 99%

Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review

Schuch

Schmidt

Zigmundo

et al. 2021

Head and Neck Pathol

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“…Lesi jinak memiliki ciri poliklonal dan disebut reaktif, sedangkan lesi ganas memiliki ciri monoklonal dan disebut limfoma. 13 Imunohistokimia merupakan bagian integral dari penegakan diagnosis dan klasifikasi limfoma. 2,9,10,13 Imunohistokimia memiliki keunggulan karena dapat menilai morfologi, lokasi-distribusi sel, serta ekspresi antigen secara simultan.…”

Section: Pembahasanunclassified

“…13 Imunohistokimia merupakan bagian integral dari penegakan diagnosis dan klasifikasi limfoma. 2,9,10,13 Imunohistokimia memiliki keunggulan karena dapat menilai morfologi, lokasi-distribusi sel, serta ekspresi antigen secara simultan. Selain itu, juga dapat menentukan tingkat keparahan (grading) dan mengevaluasi respons kemoterapi.…”

Section: Pembahasanunclassified

Perbedaan Antara Ekspresi Cd3, Cd20, Cd43 Limfoma Non-Hodgkin Sel B Dan Lesi Limfoproliferatif Reaktif

Fadli

Norahmawati

Yudhanto

et al. 2019

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Lesi limfoproliferatif sering menimbulkan masalah dalam penegakan diagnosis karena kemiripan morfologi dan pola pertumbuhan sel-sel limfoid yang menyusun lesi limfoproliferatif reaktif dan limfoma non-Hodgkin Sel B. Diagnosis sulit ditegakkan hanya dengan pulasan rutin Hematoksilin-Eosin, oleh karena itu diperlukan pemeriksaan imunohistokimia menggunakan panel antibodi yang tepat. Penelitian ini bertujuan untuk mengetahui perbedaan ekspresi CD3, CD20, CD43 sebagai panel antibodi dasar dalam menentukan karakter jinak atau ganas dari lesi limfoproliferatif. Karakter jinak diwakili oleh lesi limfoproliferatif reaktif, sedangkan karakter ganas diwakili oleh limfoma non-Hodgkin sel B. Total 50 sampel dibagi menjadi 2 kelompok, yakni kelompok A terdiri dari 25 sampel limfoma non-Hodgkin sel B dan kelompok B terdiri dari 25 sampel lesi limfoproliferatif reaktif. Keseluruhan sampel dipulas antibodi CD3, CD20, CD43. Hasil penelitian menunjukkan persentase imunopositif CD3 dan CD20 pada kelompok A dan B berbeda signifikan dengan nilai p < 0,001. Hal ini menunjukkan bahwa CD3 dan CD20 mampu membedakan karakter klonalitas jinak dan ganas dari sel penyusun lesi limfoproliferatif. Persentase imunopositif CD43 antara kelompok A dan B tidak berbeda signifikan dengan nilai p = 0,791. Hasil yang tidak berbeda signifikan mengindikasikan bahwa CD43 diekspresikan oleh dua jenis populasi sel yang berbeda. Pada kelompok A, CD43 diekspresikan oleh limfosit B neoplastik (ganas), sedangkan pada kelompok B diekspresikan oleh limfosit T. Berdasarkan hasil penelitian, panel antibodi CD3, CD20, CD43 dapat membedakan lesi limfoproliferatif jinak dan ganas, namun diperlukan korelasi morfologi dan kesesuaian pola ekspresi imunopositif dari sel-sel limfoid penyusunnya.

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“…Gamma-glutamyltransferase 1 (GGT1) could also be a potential marker for cHL [15], and cytotoxic T-lymphocyte associated protein 4 (CTLA-4) is expressed in programmed cell death-1 (PD-1) negative cHL [16]. On the other hand, CD19 is exclusively expressed, and CD20 is also found in some cases of FL [17].…”

Section: Introductionmentioning

confidence: 99%

Potential Molecular Mechanisms of Rare Anti-Tumor Immune Response by SARS-CoV-2 in Isolated Cases of Lymphomas

Barh

Tiwari

Gomes

et al. 2021

Viruses

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Recently, two cases of complete remission of classical Hodgkin lymphoma (cHL) and follicular lymphoma (FL) after SARS-CoV-2 infection were reported. However, the precise molecular mechanism of this rare event is yet to be understood. Here, we hypothesize a potential anti-tumor immune response of SARS-CoV-2 and based on a computational approach show that: (i) SARS-CoV-2 Spike-RBD may bind to the extracellular domains of CD15, CD27, CD45, and CD152 receptors of cHL or FL and may directly inhibit cell proliferation. (ii) Alternately, upon internalization after binding to these CD molecules, the SARS-CoV-2 membrane (M) protein and ORF3a may bind to gamma-tubulin complex component 3 (GCP3) at its tubulin gamma-1 chain (TUBG1) binding site. (iii) The M protein may also interact with TUBG1, blocking its binding to GCP3. (iv) Both the M and ORF3a proteins may render the GCP2-GCP3 lateral binding where the M protein possibly interacts with GCP2 at its GCP3 binding site and the ORF3a protein to GCP3 at its GCP2 interacting residues. (v) Interactions of the M and ORF3a proteins with these gamma-tubulin ring complex components potentially block the initial process of microtubule nucleation, leading to cell-cycle arrest and apoptosis. (vi) The Spike-RBD may also interact with and block PD-1 signaling similar to pembrolizumab and nivolumab- like monoclonal antibodies and may induce B-cell apoptosis and remission. (vii) Finally, the TRADD interacting “PVQLSY” motif of Epstein-Barr virus LMP-1, that is responsible for NF-kB mediated oncogenesis, potentially interacts with SARS-CoV-2 Mpro, NSP7, NSP0, and spike (S) proteins, and may inhibit the LMP-1 mediated cell proliferation. Taken together, our results suggest a possible therapeutic potential of SARS-CoV-2 in lymphoproliferative disorders.

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Contribution of immunocytochemistry to the diagnosis of usual and unusual lymphoma cases

Cited by 17 publications

References 31 publications

Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review

Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review

Perbedaan Antara Ekspresi Cd3, Cd20, Cd43 Limfoma Non-Hodgkin Sel B Dan Lesi Limfoproliferatif Reaktif

Potential Molecular Mechanisms of Rare Anti-Tumor Immune Response by SARS-CoV-2 in Isolated Cases of Lymphomas

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