Contribution of MSMB promoter region gene polymorphism to early-onset prostate cancer risk in Mexican males

Abstract

Sexually transmitted infections and its contribution to prostate cancer (PC) development have been relevant in different populations. MSMB gene polymorphism (rs10993994) has exhibited an association both with PC as well as the susceptibility to sexually transmitted infections. Hitherto, these conditions have been not studied in Mexico yet, neither if sexually transmitted infections could modify the MSMB and PC association. Herein, socio-demographic features, sexually transmitted infections records, the reproductive backgrounds, and the genetic characterisation were analysed in 322 incident PC cases and 628 population healthy controls from Mexico City. Whole PC, early-onset PC (PC at < 60 years old), late-onset PC (≥ 60 years old), and PC aggressiveness were used to evaluate the genetic variants contribution to PC risk using unconditional logistic regression models. Overall, none associations between the allelic variants of rs10993994 polymorphisms with whole and PC aggressiveness were found. Howbeit, the TT genotype carriers presented the highest susceptibility to develop early-onset PC (OR = 2.66; 95% CI = 1.41, 5.04; p = 0.03) than CC+CT carriers, both with codominant and recessive models. Although none association between whole PC and MSMB gene polymorphism was found, our results were reinforced by prior studies in European descendent populations, suggesting a contribution between rs10993994 and early-onset PC development.

LMTK2 as Potential Biomarker for Stratification between Clinically Insignificant and Clinically Significant Prostate Cancer

“…Moreover, genome-wide association studies have reported the link between a polymorphic variant (rs10993994; C > T ) located in the MSMB promoter region and higher PC risks due to the downregulation of the MSMB [ 17 , 18 ]. In addition, TT genotype shows associations with the highest susceptibility to develop PC than CC/CT genotypes [ 19 ]. Despite the fact that MSMB may be evaluated as a disease genetic risk factor, the role of MSMB in stratification of clinically significant PC cases with rising PSA after negative transrectal systematic prostate biopsy is still unknown [ 20 ].…”