Contribution of HPC1 (RNASEL) and HPCX variants to prostate cancer in a founder population

Agalliu, Ilir; Leanza, Suzanne; Smith, Lorrie; Trent, Jeffrey M.; Carpten, John D.; Bailey-Wilson, Joan E.; Burk, Robert D.

doi:10.1002/pros.21207

Cited by 30 publications

(29 citation statements)

References 46 publications

(47 reference statements)

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“…However, we failed to find any association of rs442384, rs7813, rs486907 and rs1058205, although they were previously identified to be associated with PCa in European men (Agalliu et al, 2010;Parikh et al, 2010;Liu et al, 2012). The finding provided a helpful basis for seeking genetic etiology of prostate cancer specific to northern Han Chinese, considering the increasing incident rate of PCa.…”

Section: Discussionmentioning

confidence: 47%

rs10505474 and rs7837328 at 8q24 Cumulatively Confer Risk of Prostate Cancer in Northern Han Chinese

Zhang

Sun²,

Zhu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Aims: Genome-wide association studies (GWAS) have identified several risk variants for prostate cancer (pCa) mainly in Europeans, which need to be further verified in other racial groups. We selected six previously identified variants as candidates and to define the association with PCa in Northern Han Chinese. Methods: 749 subjects from Beijing and Tianjin in Northern China were included. Six variants (rs10505474, rs7837328, rs4242384, rs7813, rs486907 and rs1058205) were genotyped by high resolution melting (HRM) assays. The individual and cumulative contribution for of the risk of PCa and clinical covariates were analyzed. Results: Among the six candidate variants, onlyrs10505474, and rs7837328, both locating at 8q24 region, were associated with PCa in our population.rs10505474 (A) was associated with PCa (OR recessive = 1.56, p=0.006); and rs7837328 (A) was associated with PCa (OR dominant = 1.38, p=0.042/OR recessive =1.99, p=0.003). Moreover, we observed a cumulative effects between them (p trend =2.58×10 -5 ). The joint population attributable risk showed the two variants might account for 71.85% of PCa risk. In addition, we found the homozygotes of rs10505474 (A) and rs7837328 (A) were associated with PCa clinical covariants (age at onset, tumor stage, respectively) (p age =0.046, P tumorstage =0.048). Conclusion: rs10505474 (A) and rs7387328 (A) at 8q24 are associated with PCa and cumulatively confer risk, suggesting the two variations could determine susceptibility to PCa in the Northern Chinese Han population.

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Section: Discussionmentioning

confidence: 47%

rs10505474 and rs7837328 at 8q24 Cumulatively Confer Risk of Prostate Cancer in Northern Han Chinese

Zhang

Sun²,

Zhu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…9,14,15 Many variants 15 described in this gene, such as Arg462Gln, have been found to be associated with sporadic prostate cancer risk among Caucasians and African Americans. 16 However, the same variant (R462Q or Arg462Gln) has been found with decreased familial prostate cancer risk in a Japanese population with the Gln/Gln genotype.…”

Section: Discussionmentioning

confidence: 99%

Predictive value in the analysis of RNASEL genotypes in relation to prostate cancer

Álvarez-Cubero

Entrala

Fernandez-Rosado

et al. 2011

Prostate Cancer Prostatic Dis

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BACKGROUND:We would like to compare the different RNASEL genotypes with the stage of the cancer using parameters such as PSA levels, Gleason score and T-stage, and to develop a clinical protocol for the monitoring of the disease for trying a better evolution of the patient. METHODS:A total of 231 patients with sporadic prostate cancer and 100 of controls were genotyped in RNASEL gene by sequencing the exons 1 and 3. A survey of clinical information was collected by a specialist following the Helsinki protocol. All patients and controls were interviewed by a researcher and signed their informed consent to participation in the study, which was approved by Ethics Committee of the hospital. The genetic information was processed and collected with an ABI PRISM Genetic Analyser 3130 using SeqScape software v.2.6. All the patients were analysed by comparing the genetic and clinical data. w 2 -tests, Monte Carlo, Fisher tests and contigency tables were performed using SPSS v.15.0 and ARLEQUIN v.3.5 software on patient population.RESULTS: Significant differences were found only between patients and controls in D541E, R461Q and I97L genotypes, the remainder of the variants did not seem relevant to our population in contrast to other populations, such as north-Caucasians, Afro Americans and Ashkenazi Jews. The genotypes associated with the worst prognoses are G/G in D541E, A/A in R462Q and A/G in I97L. The controls were included in our study to determine an approximation of the genotype in our population compared with the patients, but they did not account for the statistical process. CONCLUSIONS:The genetic profile of patients with this cancer combined with other parameters could be used as a prognosis factor in deciding to give more radical and frequent treatments, depending on personal genotype.

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“…There were 8 studies of Caucasian, 4 of African and one of Mixed population. Four studies referred to Gleason score and 3 studies about T stage in 3 different articles (Agalliu et al 2010;Wang et al 2002;Nakazato et al 2003). Eight studied came from familial source and 7 from sporadic.…”

Section: Study Inclusionmentioning

confidence: 98%

“…So far, there are thirteen case-control studies in 11 articles (Wiklund et al 2004;Agalliu et al 2010;Robbins et al 2008;Shea et al 2008;Shook et al 2007;Daugherty et al 2007;Cybulski et al 2007;Nam et al 2005;Maier et al 2005;Wang et al 2002;Rökman et al 2002) involving the role of R462Q polymorphism, and also thirteen studies in 11 articles (Wiklund et al 2004;Robbins et al 2008;Shea et al 2008;Shook et al 2007;Cybulski et al 2007;Wang et al 2002;Rökman et al 2002;Beuten et al 2010;NoonanWheeler et al 2006;Nakazato et al 2003) investigated the role of D541E polymorphism on the risk of PCa.…”

Section: Introductionmentioning

confidence: 98%

An update analysis of two polymorphisms in encoding ribonuclease L gene and prostate cancer risk: involving 13,372 cases and 11,953 controls

Zhu

et al. 2011

Genes Nutr

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Encoding ribonuclease L (RNASEL) is a ubiquitously expressed latent endoribonuclease involved in the mediation of antiviral and pro-apoptotic activities of the interferon-inducible 2-5A system. Although the relationship between RNASEL gene polymorphisms and prostate cancer (PCa) risk has been widely reported, results were somewhat controversial and underpowered. Now, we performed an update analysis of 14 publications evaluating the association between RNASEL R462Q and D541E polymorphisms and PCa risk. We conducted a literature search of PubMed database to identify all eligible articles that examined the association of RNASEL R462Q and D541E polymorphisms with PCa. Odds ratios (OR) with 95% confidence intervals (CI) were estimated to assess these association. R462Q showed a significantly elevated effect on Africans (QQ vs. RR: OR = 2.50, 95% CI = 1.28-4.87, P (heterogeneity) = 0.231). In addition, PCa men who contain 462Q genotype had a higher Gleason score ≥ 7 (OR = 1.16, 95% CI = 1.05-1.28, P (heterogeneity) = 0.906). On the other hand, D541E was associated with increased total PCa. In the stratified analysis by race, there was also significantly increased PCa in Africans and Caucasians, as well as in sporadic PCa studies (OR = 1.09, 95% CI = 1.04-1.15, P (heterogeneity) = 0.078). Our update analysis showed evidence that RNASEL R462Q and D541E polymorphisms were associated with PCa risk. Still more well-designed studies should be performed to clarify the role of these two polymorphisms in the development of PCa.

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Contribution of HPC1 (RNASEL) and HPCX variants to prostate cancer in a founder population

Cited by 30 publications

References 46 publications

rs10505474 and rs7837328 at 8q24 Cumulatively Confer Risk of Prostate Cancer in Northern Han Chinese

rs10505474 and rs7837328 at 8q24 Cumulatively Confer Risk of Prostate Cancer in Northern Han Chinese

Predictive value in the analysis of RNASEL genotypes in relation to prostate cancer

An update analysis of two polymorphisms in encoding ribonuclease L gene and prostate cancer risk: involving 13,372 cases and 11,953 controls

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