Contribution of HLA class II genes to end stage renal disease in Mexican patients with type 2 diabetes mellitus

Pérez-Luque, Elva; Malacara, Juan Manuel; Olivo-Dı́az, Angélica; Aláez, C.; Hector, Debaz; Vázquez-García, M.N.; Garay, Ma.Eugenia; Nava, Laura E; Burguete, Ana; Gorodezky, Clara

doi:10.1016/s0198-8859(00)00174-9

Cited by 21 publications

(17 citation statements)

References 38 publications

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“…Gorodezky et al [29] reported higher risk for diabetik nephropathy in patients have HLA DRB1*1502, HLA DQB1*0501 allles and lower risk in patients carrying higher DRB1*0407 allels. Also in long diabetic patients carrying higher HLA A2 alles have more seriously risk for diabetic nephropathy.…”

Section: Discussionmentioning

confidence: 99%

Association Between Human Leukocyte Antigen ( HLA ) With Chronic Renal Disease

Kodaz¹

2017

EJMI

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Section: Discussionmentioning

confidence: 99%

Association Between Human Leukocyte Antigen ( HLA ) With Chronic Renal Disease

Kodaz¹

2017

EJMI

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“…Mexican Americans, who are at highest risk of developing CKD, might share a common genetic background and ‘thrifty genotype’ with Native American Indians, themselves a group at high risk of developing diabetes mellitus and CKD 54, 61. When diabetic Mexican Americans undergo maintenance dialysis, however, they are more likely to survive than non-Hispanic whites;57, 62 which is yet another example of a paradox-within-a-paradox.…”

Section: Discussionmentioning

confidence: 99%

Role of Nutritional Status and Inflammation in Higher Survival of African American and Hispanic Hemodialysis Patients

Streja¹,

Kövesdy

Molnar

et al. 2011

American Journal of Kidney Diseases

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Background-Observational studies indicate greater survival in African American and Hispanic maintenance hemodialysis (HD) patients compared to their Non-Hispanic White counterparts, even though Blacks have shorter life expectancy than Whites in the general population. We hypothesized that this apparent survival advantage is due to a more favorable nutritional/ inflammatory profile in minority HD patients.

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“…Such investigations within native North American populations are beginning to emerge. For example, Mexican patients with T2DM have been shown to be eight times as likely to develop DESRD if they had the HLA class II gene DRB1*1502 (an HLA-DR2 allele) [34]. Segregation analysis carried out in the Pima also suggests a major gene effect contributing to diabetic nephropathy [35]; linkage analysis indicates that candidate genes may be on chromosome 7 [36, 37].…”

Section: Discussionmentioning

confidence: 99%

Increased Frequency of HLA A2/DR4 and A2/DR8 Haplotypes in Young Saskatchewan Aboriginal People with Diabetic End-Stage Renal Disease

Dyck¹,

Bohm²,

Klomp³

2003

Am J Nephrol

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Aims: To determine the association of HLA with diabetic end-stage renal disease (DESRD) in Saskatchewan aboriginal people. Methods: This was a retrospective study of HLA profiles in four groups of Saskatchewan residents with ESRD diagnosed from 1980 to 1998: aboriginal people with and without DESRD, and non-aboriginal people with and without DESRD. The aboriginal DESRD group was also subdivided into those ≤50 and >50 years of age. Frequencies of individual and combinations of HLA antigens were compared between groups and subgroups. Results: HLA data were available for 634 subjects. Young aboriginal people with DESRD had a higher frequency of HLA-A2 than older AB DESRD subjects (69 vs. 36%; p = 0.03), and of HLA-DR4 and/or DR8 compared to older AB DESRD subjects (91 vs. 68%; p = 0.07) and AB non-DESRD subjects (91 vs. 67%; p = 0.03). Over 65% of young AB DESRD subjects had either an A2/DR4 or A2/DR8 haplotype (odds ratio 5.09 [confidence intervals 1.35, 20.15] versus older AB DESRD subjects; odds ratio 3.32 [confidence intervals 1.20, 9.3] versus AB non-DESRD subjects). Forty percent of young AB DESRD subjects were homozygous for at least one of A2, DR4 or DR8. Conclusions: Our findings suggest that DESRD in young AB subjects with T2DM has a genetic basis related to HLA.

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Contribution of HLA class II genes to end stage renal disease in Mexican patients with type 2 diabetes mellitus

Cited by 21 publications

References 38 publications

Association Between Human Leukocyte Antigen ( HLA ) With Chronic Renal Disease

Association Between Human Leukocyte Antigen ( HLA ) With Chronic Renal Disease

Role of Nutritional Status and Inflammation in Higher Survival of African American and Hispanic Hemodialysis Patients

Increased Frequency of HLA A2/DR4 and A2/DR8 Haplotypes in Young Saskatchewan Aboriginal People with Diabetic End-Stage Renal Disease

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