Contribution of Hepatic Lipase, Lipoprotein Lipase, and Cholesteryl Ester Transfer Protein to LDL and HDL Heterogeneity in Healthy Women

Carr, Maria; Ayyobi, Amir F; Murdoch, Susan J.; Deeb, Samir S.; Brunzell, John D.

doi:10.1161/01.atv.0000013284.47317.95

Cited by 86 publications

(56 citation statements)

References 55 publications

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“…In Mexican-American population from San Antonio Family Heart Study, the authors [31] found no evidence for major locus effect on HDL-C levels after adjustment for apo A1 levels. While Carr et al [32] found association of buoyant LDL among carriers of -514T allele in pre-menopausal women, in Framingham Offspring Study with 2,667 subjects no association was seen [15]. These discrepancies could have been due to differences in the methods used for estimating sdLDL.…”

Section: Discussionmentioning

confidence: 93%

Association of CETP and LIPC Gene Polymorphisms with HDL and LDL Sub-fraction Levels in a Group of Indian Subjects: A Cross-Sectional Study

Todur

Ashavaid

2012

Ind J Clin Biochem

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There is an increasing interest to understand the molecular basis of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) subfractions and their association with coronary artery disease (CAD). The formation of these subfractions is greatly influenced by hepatic lipase (HL) and cholesteryl ester transfer protein (CETP) enzymes. To identify genetic markers influencing LDL and HDL subfractions and their role in CAD we performed a case-control genetic association study on 117 healthy controls and 119 angiographically verified CAD patients. Biochemical analysis was performed using standard assays. HDL-C and LDL-C subfractions were estimated using precipitation methods. Genotyping of C-514T (rs1800588) in the LIPC gene for HL and I405V (rs5882) in the CETP gene was done using PCR-based restriction enzyme analysis and sequencing. Both the polymorphisms were not associated with CAD. The C-514T was associated with increased HDL 3 -C levels in controls (P = 0.049). The I405V polymorphism was found to be associated with low levels of small dense, LDL (P = 0.038). A multiple regression analysis showed that the effects were dependent on gender and triglyceride levels. We conclude that these polymorphisms are not associated with CAD but are important determinants of HDL-C and small dense LDL particles in our population.

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Section: Discussionmentioning

confidence: 93%

Association of CETP and LIPC Gene Polymorphisms with HDL and LDL Sub-fraction Levels in a Group of Indian Subjects: A Cross-Sectional Study

Todur

Ashavaid

2012

Ind J Clin Biochem

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“…It has been demonstrated that cholesteryl ester transfer protein (CETP) is also an important determinant of LDL particle size 25,26) . In addition, lipoprotein lipase (LPL) activity and hepatic lipase activity have been shown to contribute to the formation of sd-LDL particles and could well represent significant determinants of LDL-peak particle diameter (LDL-PPD) in FH 27) . In the previous report, LDL-PPD in FH was significantly smaller than in controls.…”

Section: Discussionmentioning

confidence: 99%

Effects of Statin on Small Dense Low-Density Lipoprotein Cholesterol and Remnant-Like Particle Cholesterol in Heterozygous Familial Hypercholesterolemia

Nozue

Michishita

Ito

et al. 2008

JAT

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Aim:The effects of statin on small dense low-density lipoprotein cholesterol (sd-LDL-C) and remnant-like particle cholesterol (RLP-C) levels in heterozygous familial hypercholesterolemia (FH) have not been examined. This study aimed to clarify the effects of statin on sd-LDL-C and RLP-C levels in heterozygous FH. Methods: Seventeen patients with heterozygous FH were randomly assigned to 2 mg/day pitavastatin or 10 mg/day atorvastatin. At baseline and 12 weeks after treatment with statin, we measured sd-LDL-C and RLP-C levels.

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“…Recently, a major quantitative trait locus on chromosome 17q21 affecting LDL-PPD has been identified (34). In addition, certain constituents of lipoprotein metabolism, such as lipoprotein lipase activity and hepatic lipase activity, have been shown to contribute to the formation of small, dense LDL particles and could well represent significant determinants of LDL-PPD in FH (22).…”

Section: Discussionmentioning

confidence: 99%

“…Plasma CETP mass concentration was used to assess plasma CETP activity because they are strongly correlated (22). However, sample handling and storage conditions may influence the stability of lipid transfer activity and, consequently, could have a significant impact on the relationship between CETP mass and activity.…”

Section: Measurement Of Cetp Massmentioning

confidence: 99%

Relationship between cholesteryl ester transfer protein and LDL heterogeneity in familial hypercholesterolemia

Hogue

Lamarche

Gaudet³

et al. 2004

Journal of Lipid Research

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Small, dense LDL particles have been associated with an increased risk of coronary artery disease, and cholesteryl ester transfer protein (CETP) has been suggested to play a role in LDL particle remodeling. We examined the relationship between LDL heterogeneity and plasma CETP mass in familial hypercholesterolemia (FH). LDL particles were characterized by polyacrylamide gradient gel electrophoresis in a total of 259 FH heterozygotes and 208 nonFH controls. CETP mass was measured by enzyme-linked immunosorbent assay in a subgroup of 240 participants, which included 120 FH patients matched with 120 controls. As compared with controls, FH subjects had an 11% higher CETP mass. Moreover, LDL-peak particle diameter (LDL-PPD) was significantly smaller in FH heterozygotes than in controls (258.1 ؎ 4.8 vs. 259.2 ؎ 4.1 Å; P ‫؍‬ 0.01) after adjustment for covariates. There was also an inverse relationship between LDL-PPD and CETP mass ( R ‫؍‬ ؊ 0.15; P ‫؍‬ 0.02), and this relationship was abolished by adjustment for the FH/control status, indicating that LDL-PPD changes in FH are mediated, at least in part, by an increase in plasma CETP mass concentrations. These results suggest that increased plasma CETP mass concentrations could lead to significant LDL particle remodeling in FH heterozygotes and could contribute to the pathogenesis of atherosclerosis. -Hogue, J-C., B. Lamarche, D. Gaudet, M. Larivière, A. J. Tremblay, J. Bergeron, I. Lemieux, J-P. Després, C. Gagné, and P. Couture. Relationship between cholesteryl ester transfer protein and LDL heterogeneity in familial hypercholesterolemia.

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Contribution of Hepatic Lipase, Lipoprotein Lipase, and Cholesteryl Ester Transfer Protein to LDL and HDL Heterogeneity in Healthy Women

Abstract: Abstract-Hepatic lipase (HL) and cholesteryl ester transfer protein (CETP)

Cited by 86 publications

References 55 publications

Association of CETP and LIPC Gene Polymorphisms with HDL and LDL Sub-fraction Levels in a Group of Indian Subjects: A Cross-Sectional Study

Association of CETP and LIPC Gene Polymorphisms with HDL and LDL Sub-fraction Levels in a Group of Indian Subjects: A Cross-Sectional Study

Effects of Statin on Small Dense Low-Density Lipoprotein Cholesterol and Remnant-Like Particle Cholesterol in Heterozygous Familial Hypercholesterolemia

Relationship between cholesteryl ester transfer protein and LDL heterogeneity in familial hypercholesterolemia

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