Contribution of Fetal Programming in the Formation of Cognitive Impairments Induced by Lead Poisoning in White Rats

Соседова, Л. М.; Vokina, Vera A.; Kapustina, E. A.

doi:10.1007/s10517-019-04404-4

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…С точки зрения токсикологии интересным представляется тот факт, что пренатальное гипоксическое поражение ведет к развитию у потомства повышенной чувствительности к воздействию экотоксикантов. Показано, что при введении ацетата свинца потомству крыс, получавших нитрит натрия в дозах 5, 25 и 50 мг/ кг с 10-го по 19-ый день беременности, нарушение когнитивных функций было значительно более выражено, чем у животных без пренатальной гипоксии, и зависело от дозы метгемоглобин образователя [33]. Ингаляционная затравка толуолом (560 мг/м 3 , 4 ч. в день в течение 4-х недель) взрослых особей (2,5-3 мес.…”

Section: Discussionunclassified

Long-term consequences of acute toxic prenatal hypoxia induced by sodium nitrite in rat experiments

Savateeva-Lyubimova,

Sivak,

Aleksandrov

et al. 2023

Урал. мед. журнал

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Introduction. Gestational hypoxia plays an important role in fetal development, as it causes the development of oxidative stress and delayed psychomotor development. The aim of the study was to evaluate the prenatal effect of sodium nitrite on indices characterizing orienting and exploratory activity, mental activity and the degree of hypoxia in rat offspring. Materials and methods. Acute hypoxia was modeled by administration of sodium nitrite at a dose of 30 mg/kg intramuscularly to five pregnant rats during 16–19 days of gestation. Five females constituted a control group. In 50 born rats, orientation and exploration activity, cognitive functions, intensity of lipid peroxidation and glycolysis were studied. Results. The offspring of females that underwent acute hypoxia significantly lagged behind in the positive dynamics of body weight gain compared to control individuals. Thirty-day-old rats showed a pronounced disorder of the structure of behavioral pattern, learning process and long-term memory, increased content of diene conjugates, malonic dialdehyde and the level of lactate dehydrogenase activity in blood. Discussion. It was found that offspring whose mothers suffered acute hypoxia of toxic genesis developed pronounced behavioral disorders of psychomotor agitation and cognitive dysfunction characterized by decreased learning ability and impaired long-term memory. The content of primary and secondary products of lipid peroxidation and lactate dehydrogenase was increased in rats. The development of cellular oxidative stress under conditions of intrauterine hypoxia leads to oxygen deficiency in the fetus and a switch from tissue respiration to glycolysis, which underlies CNS damage. Conclusion. It was shown that sodium nitrite administration during the period from the 16th to the 19th day of gestation caused hyperactivity, depressed emotional status, and decreased orienting and exploratory activity and the ability to learn and retain a memory trace in rat offspring. Increased levels of diene conjugates and malonic dialdehyde, lactate dehydrogenase activity were observed in rats.

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Section: Discussionunclassified

Long-term consequences of acute toxic prenatal hypoxia induced by sodium nitrite in rat experiments

Savateeva-Lyubimova,

Sivak,

Aleksandrov

et al. 2023

Урал. мед. журнал

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“…The results of the current study showed in the histological sections of the kidneys of pregnant rats in groups treated with sodium nitrite at a concentration of 10 mg/kg during the various stages of gestation (7,16,20) days respectively as several histopathological changes represented by shrinkage and necrosis of the renal glomerulus and the occurrence of bleeding in it , widening of Bowman's space, destruction of the wall of Bowman's capsule, separation of the urinary tubules from the basement membrane, shedding of the inner layer lining the urinary tubules, hemorrhage and destruction of the urinary tissue as in the figures (9,11,13) respectively,and these effects increased in the livers of pregnant rats in groups treated with sodium nitrite at a concentration of 15 mg/kg, and increased with an increase in gestation during the different stages of gestation(20,16,7) days respectively as shown in the figures (10,12,14) respectively compared with the histological structure of the kidneys of pregnant rats in the control group whose histological sections did not show any changes other than normal during the stage of gestation as in the figure (8).…”

Section: -The Kidneysmentioning

confidence: 99%

Study of some histological effects of the preservative sodium nitrite in the fetuses and pregnant rat females

AL-Rubaie

AL–Essawi

2022

ijhs

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This study was carried out in the animal house of the College of Science at the University of Kufa from 15/11/2021 to 15/5/2022for the purpose of studying the harmful histological effects of the preservative sodium nitrite in some organs (livers, kidneys and brains) of fetuses during gestation (16,20 days) and during the three stages of gestation (7,16,20) days respectively of pregnant female rats that were treated with sodium nitrite,45 pregnant rat female of Rattns rattus type (Sprague Dawley) whose averages weights were (230) g and ages were (12) weeks, pregnant rats were divided into 3 main groups and each group contained 15 pregnant females: the first group was treated with physiological salt solution and was as a control group, while the second group was dosed sodium nitrite at a concentration of 10 mg/kg of body weight, while the third group was dosed sodium nitrite at a concentration of 15 mg/kg of body weight, each of the main groups was divided into 3 secondary groups, each of which included 5 pregnant rats, the first, second and third secondary groups from each main groups were dissected during (7,16,20) days of gestation, respectively,,,,

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“…In rats, when hypoxia was induced by unilateral uterine artery ligation on the 16th day of pregnancy, Pax6, which plays an important role in neurogenesis, showed diverse patterns in the neurogenic zone ( So et al, 2017 ). In addition, different rat models of prenatal hypoxia showed different degrees of learning and memory deficits ( Cai et al, 1999 ; Dubrovskaia and Zhuravin, 2008 ; Delcour et al, 2012b ; Vasilev et al, 2016 ; Wei et al, 2016 ; Sosedova et al, 2019 ; Zhuravin et al, 2019 ; Jia et al, 2020 ). Prenatal hypoxia (4 h/day throughout pregnancy) induces sex-dependent demethylation of the CpG site of the Crhr1 gene in the male promoter region, resulting in increased Crhr1 mRNA in the PVN region and anxiety-like behavior in adult offspring ( Wang et al, 2013 ).…”

Section: Prenatal Hypoxiamentioning

confidence: 99%

Effects of Prenatal Hypoxia on Nervous System Development and Related Diseases

et al. 2021

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The fetal origins of adult disease (FOAD) hypothesis, which was proposed by David Barker in the United Kingdom in the late 1980s, posited that adult chronic diseases originated from various adverse stimuli in early fetal development. FOAD is associated with a wide range of adult chronic diseases, including cardiovascular disease, cancer, type 2 diabetes and neurological disorders such as schizophrenia, depression, anxiety, and autism. Intrauterine hypoxia/prenatal hypoxia is one of the most common complications of obstetrics and could lead to alterations in brain structure and function; therefore, it is strongly associated with neurological disorders such as cognitive impairment and anxiety. However, how fetal hypoxia results in neurological disorders remains unclear. According to the existing literature, we have summarized the causes of prenatal hypoxia, the effects of prenatal hypoxia on brain development and behavioral phenotypes, and the possible molecular mechanisms.

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Contribution of Fetal Programming in the Formation of Cognitive Impairments Induced by Lead Poisoning in White Rats

Cited by 5 publications

References 7 publications

Long-term consequences of acute toxic prenatal hypoxia induced by sodium nitrite in rat experiments

Long-term consequences of acute toxic prenatal hypoxia induced by sodium nitrite in rat experiments

Study of some histological effects of the preservative sodium nitrite in the fetuses and pregnant rat females

Effects of Prenatal Hypoxia on Nervous System Development and Related Diseases

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