Contribution of environmental factors on the distribution of antibiotic resistance genes in agricultural soil

Yang, Fan; Zhang, Fengli; Li, Hongping; Wu, Huiying; Zhao, Hongcheng; Cheng, Xuemin; Ba, Yue; Huang, Hui; Chen, Shuaiyin; Zhu, Jingyuan

doi:10.1016/j.ejsobi.2020.103269

Cited by 16 publications

(7 citation statements)

References 55 publications

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“…Frequently related to multi-drug efflux pumps and the least common mechanism of coselection, the Co-regulatory resistance occurs when resistant genes to antimicrobial agents and heavy metals are controlled by a mutual regulatory protein (Bazzi et al, 2020). These mechanisms of co-selection support the direct correlation between antibiotic resistance genes with the concentration of antibiotics and metals found in the manure of Chinese swine farms (Yang et al, 2021).…”

Section: Genes Responsible For the Resistance To Different Metals And Antibioticsmentioning

confidence: 92%

“…Metal resistance has been described in a co-selection mechanism with antibiotic resistance, particularly relevant under environmental conditions of metal stress. The selective pressure to survive under stress conditions might contribute to plant growth-promoting bacteria evolve mechanisms to tolerate the uptake of heavy metal and/or the antibiotic presence in soil, for example (Yang et al, 2021).…”

Section: Genes Responsible For the Resistance To Different Metals And Antibioticsmentioning

confidence: 99%

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Genomic analysis and plant growth-promoting potential of a Serratia marcescens isolated from food

Silva

Miller

Pereira

et al. 2022

RSD

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A genomic analysis of the potential application of a Serratia marcescens strain in the plant-growth promotion. We performed whole-genome sequencing of Serratia marcescens isolated from a Minas Frescal Cheese. The genomic repertoire revealed a bacterium of agricultural and biotechnological interest. In the plant-growth promotion traits, we highlight genes encoding proteins possibly responsible for the biosynthesis of phytohormone indole acetic acid, organic compounds that act in iron uptake, and the Phosphate solubilization system. Genes encoding for enzymes like the versatile L-asparaginase stimulates the development of seeds and grains and can benefit the food industry due to a mitigation effect on acrylamide and notably, has medical applications as a chemotherapeutic agent or is applicable by its antimicrobial and anti-inflammatory properties. Moreover, functional diversity of genes encoding for resistance to different metals and metabolism of xenobiotics genes can be found in this strain, reinforcing its biotechnological potential. The versatile enzymes that can be produced by S. marcescens benefit the food, pharmaceutical, textile, agronomic, and cosmetic industries. The relevant genetic systems of S. marcescens described here may be used to promote plant growth and health and improve the environment. To the best of our knowledge, this is the first genome sequence report on S. marcescens isolated from cheese, with potential application as promoting plant growth and providing a baseline for future genomic studies on the development of this species.

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Section: Genes Responsible For the Resistance To Different Metals And Antibioticsmentioning

confidence: 92%

Section: Genes Responsible For the Resistance To Different Metals And Antibioticsmentioning

confidence: 99%

Genomic analysis and plant growth-promoting potential of a Serratia marcescens isolated from food

Silva

Miller

Pereira

et al. 2022

RSD

View full text Add to dashboard Cite

show abstract

“…The overuse and misuse of antibiotics in agriculture and veterinary and human medicine led to the emergence of multi-resistant pathogenic strains and the spread of antibiotic resistance around the world [ 31 , 32 ]. Nowadays, infections by antibiotic-resistant bacteria cause more than 0.7 million deaths annually worldwide, but it is estimated that such infections could kill over 10 million people by the year 2050 if the antibiotic resistance crisis cannot be controlled [ 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Insights in the Development and Uses of Alternatives to Antibiotic Growth Promoters in Poultry and Swine Production

2022

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The overuse and misuse of antibiotics has contributed to the rise and spread of multidrug-resistant bacteria. To address this global public health threat, many countries have restricted the use of antibiotics as growth promoters and promoted the development of alternatives to antibiotics in human and veterinary medicine and animal farming. In food-animal production, acidifiers, bacteriophages, enzymes, phytochemicals, probiotics, prebiotics, and antimicrobial peptides have shown hallmarks as alternatives to antibiotics. This review reports the current state of these alternatives as growth-promoting factors for poultry and swine production and describes their mode of action. Recent findings on their usefulness and the factors that presently hinder their broader use in animal food production are identified by SWOT (strength, weakness, opportunity, and threat) analysis. The potential for resistance development as well as co- and cross-resistance with currently used antibiotics is also discussed. Using predetermined keywords, we searched specialized databases including Scopus, Web of Science, and Google Scholar. Antibiotic resistance cannot be stopped, but its spreading can certainly be hindered or delayed with the development of more alternatives with innovative modes of action and a wise and careful use of antimicrobials in a One Health approach.

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“…However, soil contamination with heavy metals and antibiotics also occurs along with farming, indirectly changing the distribution of ARGs and affecting the structure and function of microbial communities in the soil. Furthermore, changes in the concentrations of soil pollutants can indirectly affect the selection pressure of soil bacterial communities, which further makes bacterial communities resistant to various pollutants to varying degrees [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Oxytetracycline/Lead Pollution Alone and in the Combined Form on Antibiotic Resistance Genes, Mobile Genetic Elements, and Microbial Communities in the Soil

Guo

Shao

et al. 2022

IJERPH

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The application of livestock manure is the leading cause of antibiotic and heavy metal pollution in agricultural soil. However, the effects of oxytetracycline (OTC) and lead (Pb) pollution in the single or combined form on antibiotic resistance genes (ARGs) in the soil need to be further studied. This study was planned to investigate the effects of OTC and Pb application on ARGs, mobile genetic elements (MGEs), and bacterial abundance in the soil. The relative abundance of ARGs and MGEs increased by 0.31-fold and 0.03-fold after the addition of 80 mg kg−1 Pb to the soil, and by 0.49-fold and 0.03-fold after the addition of 160 mg kg−1 Pb. In addition, under the premise of the existence of OTC, the inhibitory effect of a low concentration of Pb on ARG is stronger than that of a high concentration of Pb, resulting in a lower abundance of ARGs. The abundance of ARGs and MGEs increased by 0.11-fold and 0.17-fold after the addition of OTC (30 mg kg−1) to the soil at a Pb concentration of 80 mg kg−1 and by 0.18-fold and 0.04-fold at a Pb concentration of 160 mg kg−1. The addition of OTC and Pb in the soil also decreased the many bacterial communities such as Bacteroidetes, Proteobacteria, Acidobacteria, and Firmicutes. Redundancy analysis (RDA) showed that organic matter content and pH were positively correlated with the abundance of ARGs and MGEs. At the same time, electrical conductivity (EC) had a negative correlation with the abundance of ARGs and MGEs in the soil. Intl1 was significantly associated with tetB, sul1, tetQ, sul2, and sul3. Network analysis illustrated that Actinobacteria, Bacteroidetes, and Proteobacteria were the main host bacteria causing changes in the abundance of ARGs and MGEs, and they were also predominant phylum in the culture environment. This conclusion can provide a reference for the related research of ARGs in soil.

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Contribution of environmental factors on the distribution of antibiotic resistance genes in agricultural soil

Cited by 16 publications

References 55 publications

Genomic analysis and plant growth-promoting potential of a Serratia marcescens isolated from food

Genomic analysis and plant growth-promoting potential of a Serratia marcescens isolated from food

Insights in the Development and Uses of Alternatives to Antibiotic Growth Promoters in Poultry and Swine Production

Effects of Oxytetracycline/Lead Pollution Alone and in the Combined Form on Antibiotic Resistance Genes, Mobile Genetic Elements, and Microbial Communities in the Soil

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