Contribution of drug doses and conditioning periods to psychomotor stimulant sensitization

Todtenkopf, Mark S.; Carlezon, William A.

doi:10.1007/s00213-005-0259-1

Cited by 24 publications

(16 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Following 10 mg/kg IP cocaine injections, locomotor sensitization emerged rapidly in cocaine-preferring but not saline-preferring postpartum females after only four exposures, replicating the induction phase of sensitization reported by others (Post and Rose 1976) and supporting proposed correlations between cocaine's motoric and motivational effects (Wise and Bozarth 1987). This locomotor sensitization emerged using short (30 min) conditioning sessions, indicating that longer (60-120 min) exposures are not necessary to produce sensitization to 10 mg/kg IP cocaine (Todtenkopf and Carlezon 2006). Locomotor sensitization did not emerge in cocaine-preferring females given 20 mg/kg IP, possibly due to the number of subjects (i.e., power) or relatively large variability.…”

Section: Locomotion Across the Cpp Proceduressupporting

confidence: 81%

“…Our characterization of cocaine-induced locomotion and the induction phase of motoric sensitization in the postpartum female during conditioning sessions with IP cocaine builds upon existing dose-response locomotor analyses in males and cycling female rats (Sell et al 2000;Hu and Becker 2003;Todtenkopf and Carlezon 2006). Locomotion during CPP testing characterizes subjects' behavioral responsivity to cocaine-and saline-associated chambers during their expression of conditioned chamber preference, offering unique insight into individual differences in motivation (Seip and Morrell 2007) and extending prior CPP work using other abused drugs (Parker 1992).…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Incentive salience of cocaine across the postpartum period of the female rat

et al. 2008

View full text Add to dashboard Cite

Rationale-Objectives-Our prior conditioned place preference (CPP) work demonstrates that late (day16) postpartum female rats consistently prefer cocaine-over pup-associated chambers, whereas far fewer early postpartum (day8) females prefer the cocaine-associated chamber. The present study examines early and late postpartum females' preference for a cocaine-associated chamber when contrasted with a chamber associated with saline (rather than pups).Materials and methods-Postpartum females were tested for conditioned preference for chambers associated with cocaine (10 mg/kg subcutaneous (SC) or 0.5, 5, 10, or 20 mg/kg intraperitoneal (IP) injections) versus saline; preferences of virgin female and male rats for select cocaine stimuli (10mg/kg SC or IP) were also tested. Locomotion was recorded during CPP conditioning and testing.Results-Early and late postpartum females expressed strikingly similar preference for the cocaineassociated chamber across all administration routes and doses. IP cocaine produced an orderly, inverted U-shaped dose-preference curve, with preference peaking at the 5 mg/kg dose (83% of females). While many postpartum females preferred 10mg/kg cocaine administered either SC or IP, both virgin females and males expressed strong aversion to SC cocaine and, while virgin females strongly preferred IP cocaine, males remained relatively indifferent. Across 10mg/kg IP cocaineconditioning sessions, locomotor sensitization occurred exclusively in cocaine-but not salinepreferring postpartum females. Locomotor rate was lower in preferred versus nonpreferred chambers at CPP test.Conclusions-Early and late postpartum females may be equally and uniquely susceptible to sampling and/or abuse of modestly salient doses of cocaine (10mg/kg SC; 5mg/kg IP) compared to virgin females and/or males.

show abstract

Section: Locomotion Across the Cpp Proceduressupporting

confidence: 81%

Section: Introductionmentioning

confidence: 98%

Incentive salience of cocaine across the postpartum period of the female rat

et al. 2008

View full text Add to dashboard Cite

show abstract

“…However, these brain regions are critical integrators of sensori-motor, affective, and cognitive information, and therefore the behavioral effects of cocaine are determined not only by its pharmacological properties, but also the physiological and contextual states of the animal (Barrett, 1987;Falk and Feingold, 1987). For example, prior drug experience, stress and the environment in which cocaine is administered have been shown to modulate behavioral responses to acute and chronic cocaine (Robinson and Berridge, 1993;Shaham et al, 2003;Badiani and Robinson, 2004;Todtenkopf and Carlezon, 2006). These factors are thought to contribute to the development and maintenance of addiction (Koob and Le Moal, 1997;Lu et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Exposure to the Selective κ-Opioid Receptor Agonist Salvinorin A Modulates the Behavioral and Molecular Effects of Cocaine in Rats

Chartoff

Potter

Damez-Werno

et al. 2008

Neuropsychopharmacol

View full text Add to dashboard Cite

“…Previous investigations of cocaine effects on locomotor activity with rodents have typically utilized a trial length of 60 min or less [20,21,22]. Figure 3 represents the mean photobeam breaks for the first 60 min of the 150 min trial for groups that received saline, or 5, 10, or 20 mg/kg cocaine.…”

Section: Resultsmentioning

confidence: 99%

Cocaine sensitization in male quail: Temporal, conditioning, and dose-dependent characteristics

Geary

Akins

2007

Physiology & Behavior

View full text Add to dashboard Cite

Chronic cocaine administration typically results in increased locomotor activity, known as behavioral sensitization. Investigating the time course of locomotor activity across trials may provide a more detailed analysis of the temporal changes that might occur within sensitization. Prior research with rodents shows that the peak of locomotor activity shifts from acute to chronic drug administration. The purpose of the current experiment was to investigate acute versus chronic cocaine effects on locomotor activity in an avian species, Japanese quail, and to investigate whether this phenomenon is dose dependent. Subjects received daily ip injections of saline or 5, 10, or 20 mg/kg cocaine for 20 days. Following each injection, birds were placed in standard locomotor activity chambers, and activity was recorded for 150 min. A cocaine challenge was given after a ten-day withdrawal period. Two retraining trials were given to reestablish cocaine responding prior to a saline challenge in the drug-paired environment. Results showed that repeated administration of the 10 mg/kg dose of cocaine enhanced activity across 120 min compared with acute administration. In contrast, repeated administration of the 20 mg/kg dose resulted in greater cocaine-induced activity for 60 min compared with acute administration. In addition, behavioral sensitization was shown to be dose-dependent and appeared to be due, at least in part, to conditioning.

show abstract

Contribution of drug doses and conditioning periods to psychomotor stimulant sensitization

Abstract: Repeated association of the peak behavioral effects of high doses of amphetamine or cocaine with the drug-paired environment produces maximal expression of sensitized locomotor responses. Certain testing conditions appear to disrupt sensitization to these same doses of the drugs.

Cited by 24 publications

References 42 publications

Incentive salience of cocaine across the postpartum period of the female rat

Incentive salience of cocaine across the postpartum period of the female rat

Exposure to the Selective κ-Opioid Receptor Agonist Salvinorin A Modulates the Behavioral and Molecular Effects of Cocaine in Rats

Cocaine sensitization in male quail: Temporal, conditioning, and dose-dependent characteristics

Contact Info

Product

Resources

About