Contribution of Double Strand Break Repair Gene XRCC3 Genotypes to Nasopharyngeal Carcinoma Risk in Taiwan

Abstract

The DNA double strand break repair protein XRCC3 plays a central role in removing double strand breaks from the genome and defects in cellular repair capacity is closely related to human cancer initiation. Therefore, we aimed to investigate the contribution of XRCC3 genotypes to individual nasopharyngeal carcinoma (NPC) susceptibility. In this hospital-based population research, the genotyping and analyzing of XRCC3 rs1799794, rs45603942, rs861530, rs3212057, rs1799796, rs861539, rs28903081 in a large Taiwanese population was performed. Totally, 176 NPC patients and 880 age- and gender-matched healthy controls were genotyped and analyzed by PCR-RFLP method. The results showed that there was a differential distribution among NPC and control subjects in the genotypic (P = 0.000488) and allelic (P = 0.0002) frequencies of XRCC3 rs861539. As for the gene-environment interaction, we have firstly provided evidence showing that there is an obvious joint effect of XRCC3 rs861539 CT and TT genotypes with individual smoking habits on increased NPC risk. In conclusion, the T allele of XRCC3 rs861539, interacts with smoking habit in increasing NPC risk, may be an early detection marker for NPC.

Contribution of excision repair cross-complementing group 1 genotypes to triple negative breast cancer risk

“…Hence, we examined the genotypes of several DNA DSB repair genes, such as X-Ray Repair Cross Complementing 3 (XRCC3) , XRCC6 , XRCC7 , which are involved in the DSB repair system. The associations of these DNA repair genes with multiple types of cancer and diseases, including nasopharyngeal carcinoma [ 41 ], lung cancer [ 42 ], leiomyoma [ 43 ], breast cancer [ 44 ], hepatocellular carcinoma [ 45 ], and especially TNBC [ 46 ], have been explored in the literature.…”

Rad51 paralogs and the risk of unselected breast cancer: A case-control study

“…Owing to crucial role played by this heterodimer in several steps of HR (binding of DNA, resolution of Holiday junctions) [12], a polymorphism affecting its formation may thus influence the capacity of the whole HR DNA repair machinery and play its role in cancer development. Evidence in favor of this hypothesis is, still, rather scarce, as in addition to our previous study in which the Xrcc3 94 His allele was found to be associated with increased risk of HNC [46], only four other studies investigating the association between 94 Arg/His SNP and risk of various cancers exist [60][61][62][63]. These studies were, however, conducted in Taiwanese population completely lacking any variability at this locus, so they failed to provide any valuable information on plausible role of rs3212057 in cancer risk modulation.…”

RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer

“…In the case of studies conducted by Mittal et al [33], no direct relationship was found between the occurrence of rs1799796 polymorphism in XRCC3 and the incidence of bladder cancer. In addition, the studied polymorphism seems to be not related to the incidence of nasopharyngeal cancer as well as head and neck cancer [27, 34]. However, a meta-analysis of 5302 cases of ovarian cancer compared to 8075 control cases revealed statistically significant correlation of rs1799794 and rs1799796 polymorphism in XRCC3 and an increased risk of developing ovarian cancer in Caucasians, Asian, and African population [35].…”