Contribution of Diffusion-Weighted Imaging to Dynamic Contrast-Enhanced MRI in the Characterization of Breast Tumors

Abstract

The combination of DWI and DCE-MRI has the potential to increase the specificity of breast MRI.

Comparison of apparent diffusion coefficient values among different MRI platforms: a multicenter phantom study

“…Under this condition, receiver operative characteristic (ROC) curve analyses are performed to determine cutoff ADC values to differentiate between benign and malignant lesions. Recently, cutoff points for ADC values have increasingly been suggested to differentiate between benign and malignant lesions in different organs (3,4,7,8). However, reliable and reproducible cutoff values have not yet been confirmed.…”

Differentiation between Benign and Malignant Breast Lesions Using ADC on Diffusion-Weighted Imaging at 3.0 T

“…et al [18]. Diffusionweighted imaging (DWI) is the techniques that are performed to increase MRI specificity [7] [8]. The sensitivity of MRI for breast cancer detection ranges from 85% -100% [19] [20], and specificity ranges from only 37% -88% [21] [22].…”

Diagnostic value of apparent diffusion coefficients to differentiate benign and malignant breast lesions

“…In the breast, the sensitivity of MRI in differentiating benign and malignant lesions is 90%, and its specificity is 72% (Peters et al, 2008). Recently, with advances in ultrafast MRI techniques, new functional sequences such as diffusion-weighted imaging (DWI) offer the potential of improving the accuracy of breast MRI (Guo et al, 2002;Hatakenaka et al, 2008;Kul et al, 2011;Sonmez et al, 2011). DWI gives information of characteristics of the microscopic cellular environment including cell density, cell organization, and membrane integrity, by measuring the mobility of water molecules in vivo (Marini et al, 2007).…”