Contribution of different mechanisms to the resistance to fluoroquinolones in clinical isolates of Salmonella enterica

Abstract

Efflux pump inhibitors may inhibit the major AcrAB-TolC in Salmonella efflux systems which are the major efflux pumps responsible for multidrug resistance in Gram-negative clinical isolates.

Increased quinolone resistance among typhoid Salmonella isolated from Egyptian patients

“…Resistant typhoid strains, however, have been recently reported [9,24]. There are limited data, if any, reporting quinolone resistance among Egyptian typhoidal Salmonella isolates [15]. We showed that NA resistance increased from 0% in 1993 [16] to 15% in this study, which was similar to what was found (15%) in a report from Vietnam [25] and another (16%) from Japan [26].…”

“…There are limited data, if any, reporting quinolone resistance among Egyptian isolates of typhoidal Salmonella [15]. In this regard, we previously reported that all typhoidal Salmonella isolated from patients at Minia Governorate were sensitive to quinolones [16].…”

Molecular characterization of antimicrobial susceptibility of Salmonella isolates: First identification of a plasmid carrying qnrD or oqxAB in Taiwan

“…Rushdy et al 31 showed that five Salmonella isolates totally resistant to all quinolones had alterations in outer membrane proteins, including disappearance of some or all of these proteins: Omp-A, Omp-C, Omp-D, and Omp-F. The role of Omp loss in quinolone resistance was clarified in E. coli, 32 but is still unclear in Salmonella.…”

Interactions of Organic Acids with Salmonella Strains from Feedlot Water-Sprinkled Cattle

“…The MIC M s for the major portion of the Salmonella strains here with citric and lactic acids were also observed about 1 pH unit lower at pH 4.1 and pH 4.2. Salmonella enterica also has efflux systems, and efflux pumps or overexpressed efflux pumps can contribute too many classes of chemical resistance [43]. Also, S. enterica has been shown to display arginine-dependent acid-resistance [44].…”