Contribution of demographic, psychological and disease-related factors to quality of life in women with high-grade vulval intraepithelial neoplasia

Shylasree, T. S.; Karanjgaokar, V.; Tristram, Amanda; Wilkes, A. R.; MacLean, Allan; Fiander, Alison

doi:10.1016/j.ygyno.2008.04.023

Cited by 29 publications

(33 citation statements)

References 24 publications

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“…Other studies have found that age and additional psychological factors (depression and anxiety) influenced the QoL, but they did not find diseasespecific factors after surgery for vulvar in-situ cancer. 27 The low number of patients is a problem for most studies on vulvar carcinoma, including the present study. The low incidence and localized treatment make it difficult to launch larger studies.…”

Section: Linear Discriminant Analysismentioning

confidence: 90%

Quality of life and sexual function after surgery in early stage vulvar cancer

Forner

Dakhil²,

Lampe³

2015

European Journal of Surgical Oncology (EJSO)

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Section: Linear Discriminant Analysismentioning

confidence: 90%

Quality of life and sexual function after surgery in early stage vulvar cancer

Forner

Dakhil²,

Lampe³

2015

European Journal of Surgical Oncology (EJSO)

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“…Wang et al observed similar results for sexual impact and self-image, but there was also a substantial impact of GW on worries and concerns and less impact on partner issues and transmission [41]. It is particularly notable that the impact of GW on psychosocial burden appears to be greater than that of diseases such as VIN2/3, which are considered to be more severe from a clinical perspective and have been shown to have a significant impact on sexual functioning in previous studies [30,45]. The high psychosocial impact of GW may be because they are visible and distressing and associated with discomfort and feelings of anxiety, depression, anger, fear of contagiousness, shame and embarrassment [22,23,25,46].…”

Section: Discussionmentioning

confidence: 99%

Impact of human papillomavirus-related genital diseases on quality of life and psychosocial wellbeing: results of an observational, health-related quality of life study in the UK

et al. 2013

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BackgroundData on the psychosocial burden of human papillomavirus (HPV)-related diseases other than cervical cancer are scarce. The objectives of this study were to measure and compare the psychosocial burden and the impact on health-related quality of life (HRQoL) of HPV-related lower genital tract diseases and genital warts (GW) using several generic and disease-specific instruments.MethodsOverall, 842 individuals with normal cervical cytology (n = 241), borderline nuclear abnormalities and/or mild dyskaryosis (n = 23), cervical intraepithelial neoplasia (CIN)1 (n = 84), CIN2/3 (n = 203), vulval intraepithelial neoplasia (VIN)2/3 (n = 43), GW (n = 186) and a history of GW (non-current) (n = 62) were included. The generic European Quality of Life Index Version 5D (EQ-5D) questionnaire was completed by patients with GW and VIN2/3. Sexual functioning was evaluated using the Change in Sexual Functioning Questionnaire (CSFQ). Psychosocial impact was measured in women using the HPV Impact Profile (HIP) questionnaire. HRQoL was assessed using a GW-specific questionnaire, the Cuestionario Especifico en Condilomas Acuminados (CECA) (completed by patients with GW and history of GW). For each instrument, scores were compared between groups using the Student's t-test. In addition, utility loss due to GW and VIN2/3 was evaluated by comparing mean EQ-5D scores weighted by age and sex with the UK general population normal values.ResultsA significant psychosocial impact was found in women diagnosed with HPV-related genital diseases, particularly in those with GW. The health state of younger adults with GW was significantly impaired compared with UK normal values (mean EQ-5D index score 0.86 vs 0.94, p < 0.001 for 18–24-year-olds; 0.87 vs 0.93, p = 0.030 for 25–34-year-olds). VIN2/3 was found to have a significant negative impact on sexual functioning, and women with VIN2/3 had a highly impaired health state compared with women in the UK general population (weighted mean EQ-5D index score 0.72 vs 0.89, p < 0.001; weighted mean Visual Analogue Scale score 62 vs 85, p < 0.001).ConclusionsHPV-related lower genital tract lesions and GW significantly impair psychosocial wellbeing and HRQoL. The psychosocial aspects of HPV-related diseases need to be considered when evaluating the potential benefit of HPV vaccination.

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“…To test these hypotheses, HPV16 methylation, integration and gene expression were investigated in a cohort of 25 predominantly VIN patients. VIN is a precursor lesion of invasive vulval carcinoma, and a painful, distressing and chronic condition which causes considerable psychosexual morbidity [21,22]. The VIN cohort was selected as a high proportion of VIN patients are positive for HPV16 [23] and integration occurs in around 40% of high grade VIN [24].…”

Section: Objectivesmentioning

confidence: 99%