Contribution of dectin-1 and granulocyte macrophage–colony stimulating factor (GM-CSF) to immunomodulating actions of β-glucan

Harada, Toshie; Ohno, Naohito

doi:10.1016/j.intimp.2007.12.011

Cited by 48 publications

(46 citation statements)

References 69 publications

(85 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We have found that there are strain differences in the reactivity of mice to b-glucan, and that DBA/1 and DBA/2 mice are highly sensitive to b-glucan in vitro [4,8] and in vivo [15]. SCG induced leukocytes from DBA/1 and DBA/2 mice to produce large amounts of interferon-g (IFN-g), tumor necrosis factor-a (TNF-a), interleukin-12p70 (IL-12p70), and granulocyte macrophage -colony stimulating factor (GM-CSF) in vitro, and GM-CSF is one of the key factors in the reactivity to b-glucan [16,17].…”

Section: Introductionmentioning

confidence: 88%

“…CSBG and OX-CA, which are derived from Candida albicans, have long side chains of irregular length [20]. Solubility plays an important role in the induction by glucans in DBA/2 mice [4]. OX-CA, from C. albicans, is used as a particle b-glucan in investigations of cellular receptors and molecular mechanisms, whereas SCG is a soluble b-glucan [11].…”

Section: Vol 58 2009mentioning

confidence: 99%

“…The finding suggests DBA/2 mice to be a useful model for studying b-glucan. We also reported that the pattern of the response of the leukocytes differed between soluble glucan and particulate glucan [4]. In this study, we investigated the activity of CRDO in leukocytes from DBA/2 mice, and compared it with that of SCG.…”

Section: Introductionmentioning

confidence: 97%

“…showing antitumor activity [3,4]. SCG enhanced the hematopoietic response in cyclophosphamide-treated leukopenic mice [5,6].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cytokine induction by a linear 1,3-glucan, curdlan-oligo, in mouse leukocytes in vitro

et al. 2009

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 88%

Section: Vol 58 2009mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

“…showing antitumor activity [3,4]. SCG enhanced the hematopoietic response in cyclophosphamide-treated leukopenic mice [5,6].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cytokine induction by a linear 1,3-glucan, curdlan-oligo, in mouse leukocytes in vitro

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Very few reports have suggested that this mushroom exhibits antitumor and antiallergic activities (Ohno et al, 2000;Yamamoto et al, 2009) and its major principles are identified as polysaccharide fractions composed of a backbone of β-(1→3)-linked D-glucopyranosyl residues with β-D-glucopyranosyl groups joined through O-6 and O-2 of D-glucose (Tada et al, 2007;Park et al, 2009). Interleukin (IL)-8, GM-CSF and interferon (IFN)-γ are reported to be produced by Sparassis crispa β-glucan (Harada et al, 2002;Nameda et al, 2003;Harada and Ohno, 2008). In addition, this mushroom has been also reported to contain some chemical constituents such as sequiterpenoids and benzoate derivatives that possess antifungal and antibacterial activities (Harada et al, 2005;Kodani et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Mitogen activated protein kinases are prime signalling enzymes in nitric oxide production induced by soluble β-glucan from Sparassis crispa

Lee

Byeon

et al. 2010

Arch. Pharm. Res.

View full text Add to dashboard Cite

Sparassis crispa (SC) is an edible mushroom that harbours β-glucans reported to possess immunostimulatory and anticancer properties. The role of SC in regulating the functional activation of macrophages is yet to be fully elucidated. The objective of this study was to investigate the molecular mechanism underlying the immune-stimulatory function of Sparassis crispa soluble β-glucan (Sc-SG) on macrophages. According to this study, Sc-SG was able to stimulate nitric oxide (NO) production as well as enhance the expression of inducible NO synthase (iNOS) from macrophage-like RAW264.7 cells. NO production was strongly suppressed by mitogen-activated protein kinase (MAPK) inhibitors such as U0126, extracellular signal-regulated kinase, SB203580, a p38 inhibitor, and SP600125, a c-Jun N-terminal kinase inhibitor. Thus, indicating that Sc-SG-induced NO release is possibly mediated by MAPK. Sc-SG induced phosphorylation of extracellular signal-regulated kinase, p38, and JNK in a time-dependent manner. Moreover, Sc-SG triggered the phosphorylation and translocation of c-Jun and c-Fos, components of the transcription factor AP-1, activated by MAPK. The results of this study suggest that MAPK may be a major signaling enzyme that regulates the Sc-SG-mediated NO production in macrophages.

show abstract

Scleroglucan als Antibiotikaersatz in der Tierzucht

Wrenger

Hevekerl

Breves

et al. 2009

Chemie Ingenieur Technik

View full text Add to dashboard Cite

Biotenside sind biologisch abbaubar, von geringer Toxizität und können aus biologischen Abfallstoffen und nachwachsenden Rohstoffen produziert werden. Sie werden als Detergenzien in der pharmazeutischen, kosmetischen und in der Lebensmittelindustrie eingesetzt. Der Organismus der Wahl für die Herstellung von Rhamnolipiden, die auch kommerziell erwerbbar sind, ist bisher das human-pathogene Bakterium Pseudomonas aeruginosa.Das Ziel dieser Arbeit ist die Erhöhung der Produktivität eines nicht-pathogenen Produktionsstammes unter optimierten Bedingungen. Dieser Stamm produziert ein neuartiges Rhamnolipid, welches aus zwei Rhamnosemolekülen und zwei b-Hydroxytetradecansäure-Resten zusammengesetzt ist. Die bisher höchste erreichte Produktivität beträgt 0,02 g Rhamnose-Äquivalente pro Stunde und pro Liter Fermentationsbrühe. Eine Optimierung des Mediums ist eine Möglichkeit, die zu einer höheren Ausbeute an Rhamnolipid führen könnte. Um das Medium zu optimieren, wird die Response Surface Methode basie-rend auf einer Elementaranalyse des nicht-pathogenen Produktionsstammes angewandt. Die Fermentationen werden mit dem sechsfachen Parallelbioreaktorsystem Sixfors durchgeführt. Das Rhamnolipid wird mit einer Mitteldruckchromatographieanlage mit den Lösungsmittelsystemen Chloroform/ Methanol und Chloroform/Methanol/ Essigsäure aufgereinigt. Die Reinheit des Rhamnolipides wurde bereits mittels Kernspinresonanz nachgewiesen.

show abstract

Contribution of dectin-1 and granulocyte macrophage–colony stimulating factor (GM-CSF) to immunomodulating actions of β-glucan

Cited by 48 publications

References 69 publications

Cytokine induction by a linear 1,3-glucan, curdlan-oligo, in mouse leukocytes in vitro

Cytokine induction by a linear 1,3-glucan, curdlan-oligo, in mouse leukocytes in vitro

Mitogen activated protein kinases are prime signalling enzymes in nitric oxide production induced by soluble β-glucan from Sparassis crispa

Scleroglucan als Antibiotikaersatz in der Tierzucht

Contact Info

Product

Resources

About