Contribution of cell block obtained by endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of malignant diseases and sarcoidosis

Erer, Onur Fevzi; Erol, Serhat; Anar, Ceyda; Aydoğdu, Zekiye; Aktoğu, Serir

doi:10.4103/2303-9027.180763

Cited by 16 publications

(13 citation statements)

References 13 publications

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“…In a similar study,[ 21 ] the contribution of CBs to the diagnostic yield of EBUS-TBNA for cases of malignancy and sarcoidosis was assessed. When cytological examination of smears was not diagnostic, but CB found granulomatous inflammation or malignancy, it was defined as “contribution to diagnosis by CB.” When cytological examination of smears was reported as only malignancy, but CB or immunohistochemical staining (IHCS) reported the subtype of cancer, it was defined as “contribution to subclassification by CB” [ Table 6 ].…”

Section: Discussionmentioning

confidence: 99%

Role of Endobronchial ultrasound guided transbronchial needle aspiration with cellblocks in diagnosis and subtyping of intrathoracic lesions: Two year experience from a tertiary care center

Verma

Khan

Rao

et al. 2021

J Cytol

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Background: Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) allows precise real-time sampling of intrathoracic lesions and is a minimally invasive, safe, and cost effective technique with high diagnostic yield. The aim of the current study is to evaluate utility of EBUS-TBNA cytology with cellblocks (CBs) in the diagnosis and subtyping of the intrathoracic lesions. Materials and Methods: It was a prospective study conducted from October 2015 to October 2017. We received 233 cases of intrathoracic lesions for EBUS-TBNA, of which CB was made in 217 cases. A flexible endobronchial ultrasound scope was used to sample the lesions. Results: There were 89 females and 128 males amongst the total 217 patients (age range: 14–85 years, mean age: 48.35 years). The smears from EBUS-TBNA contained adequate material in 137/144 [95.1%] non-neoplastic cases and 34/36 [94.4%] of the neoplastic cases, whereas the CBs provided adequate material in 94/144 [65.3%] non-neoplastic cases and 37/40 [92.5%] neoplastic cases. The CB helped subtyping the malignancy in 19 cases and of these immunohistochemistry (IHC) was done on the CB in 15 cases. The biopsy was non-diagnostic in 17/36 cases of granulomatous pathology and 4/18 neoplastic cases diagnosed with EBUS-TBNA.3. Conclusions: EBUS-TBNA provides rapid diagnosis through cytology and the material recovered in the same setting for the CB preparation can be used for immunohistochemical analysis and it may at times provide the diagnosis in cases where the smears are non-diagnostic.

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Section: Discussionmentioning

confidence: 99%

Role of Endobronchial ultrasound guided transbronchial needle aspiration with cellblocks in diagnosis and subtyping of intrathoracic lesions: Two year experience from a tertiary care center

Verma

Khan

Rao

et al. 2021

J Cytol

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“…In our study, the primary advantage of adding cell blocks to the diagnostic flow was a marked increase in the definite subtyping of malignancy which confirms the findings of other studies. [ 14 15 16 ] This was primarily an effect of the ease with which IHC could be applied to cell blocks. The extent of increased information due to subtyping is greater than reported by some studies,[ 15 16 ] possibly because many of the tumors were difficult to classify due to the poor differentiation, but is similar to others.…”

Section: Discussionmentioning

confidence: 99%

“…[ 14 15 16 ] This was primarily an effect of the ease with which IHC could be applied to cell blocks. The extent of increased information due to subtyping is greater than reported by some studies,[ 15 16 ] possibly because many of the tumors were difficult to classify due to the poor differentiation, but is similar to others. [ 20 ] The increase in the proper subtype given is essential for selecting further treatment and investigations, especially for Gemcitabine therapy, radiotherapy and selection of molecular markers for targeted therapy.…”

Section: Discussionmentioning

confidence: 99%

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The value and limitations of cell blocks in endobronchial ultrasound-guided fine-needle aspiration cytology: Experience of a tertiary care center in North India

Bharati

Neha

Rao

et al. 2021

J Cytol

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Background: Endobronchial ultrasound (EBUS)-guided fine-needle aspiration cytology (FNAC) is recommended for diagnosing bronchial neoplasms and evaluating mediastinal lymph nodes. However, it may not be possible to subtype or definitely categorize many bronchial neoplasms on FNAC smears alone. Obtaining adequate diagnostic material is often a problem. In such cases, cell blocks made from FNAC material may serve as a useful adjunct. Aim: To study the value and limitations of cell blocks in adding diagnostic information to EBUS guided FNAC smears. Material and Methods: One hundred and eighty-five cases of EBUS guided FNAC having concomitant cell blocks were reviewed. The cases were evaluated for the extent of adequacy, of definite benign/malignant categorization and of definite subtyping in malignant tumors in these cases. The proportion of cases in which cell blocks added information to FNAC smears alone for the above parameters were calculated. Results: Cell blocks provided additional information in 31 out of 185 cases. Cell blocks were necessary for subtyping 24/59 malignant tumors, definite categorization into benign and malignant in 10/140 adequate samples, and increasing adequacy in 6/185 total samples. A total of 45 samples were inadequate in spite of adding information from cell blocks to smears. Conclusion: Cell blocks added clinically significant information to EBUS guided FNAC and should be used routinely. To make it more useful, alternative methods of cell block preparation (including proprietary methods) may be evaluated.

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“…EBUS-TBNA provides a higher diagnostic yield than conventional bronchoscopy in cases of lymphoma, lung cancer, sarcoidosis, and TB. [23242526272829] It can reduce the number of punctures and improve the positivity rate. TBNA is performed under real-time monitoring of ultrasound images, which effectively avoids damage to the surrounding large blood vessels and improves the safety and accuracy.…”

Section: Advantages and Disadvantages Of Pediatric Endobronchial Ultrmentioning

confidence: 99%

Endobronchial ultrasound: Echoing in the field of pediatrics

Qin

Wei

2018

Endosc Ultrasound

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Endobronchial ultrasound (EBUS) is a useful technique for the diagnosis and staging of the lung and mediastinal lesions, which is crucial for selecting treatment protocol. Under EBUS guidance, transbronchial needle aspiration (TBNA) is widely applied for obtaining specimens for histological, cytological, and molecular evaluation. Recently, the EBUS scope designed for adults has been used in large pediatric candidates. The presence of lung masses and mediastinal lymphadenopathy in the pediatric population presents a diagnostic challenge; however, EBUS is a promising tool for pediatricians to address these challenging issues. In some centers, the adult EBUS echobronchoscope is applied in transesophageal procedures for pediatric patients. EBUS-guided TBNA can also be used to perform minimally invasive interventional therapy, such as fiducial marker placement for assisting precision radiation, brachytherapy, and radiofrequency ablation therapy. With the development of EBUS equipment designed specifically for children, pediatric EBUS will play an increasingly important role.

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Contribution of cell block obtained by endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of malignant diseases and sarcoidosis

Cited by 16 publications

References 13 publications

Role of Endobronchial ultrasound guided transbronchial needle aspiration with cellblocks in diagnosis and subtyping of intrathoracic lesions: Two year experience from a tertiary care center

Role of Endobronchial ultrasound guided transbronchial needle aspiration with cellblocks in diagnosis and subtyping of intrathoracic lesions: Two year experience from a tertiary care center

The value and limitations of cell blocks in endobronchial ultrasound-guided fine-needle aspiration cytology: Experience of a tertiary care center in North India

Endobronchial ultrasound: Echoing in the field of pediatrics

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