Contribution of cardiometabolic risk factors to estimated glomerular filtration rate decline in Indigenous Australians with and without albuminuria ‐ the eGFR Follow‐up Study

Abstract

Over a 3 year period, marked eGFR decline was observed with greater baseline albuminuria. Cardiometabolic risk factors were not strong predictors for eGFR decline in Indigenous Australians without albuminuria. Longer follow-up may elucidate the role of these predictors and other mechanisms in chronic kidney disease progression in this population.

Baseline liver function tests and full blood count indices and their association with progression of chronic kidney disease and renal outcomes in Aboriginal and Torres Strait Islander people: the eGFR follow- up study

“…The follow-up was the time from the date of baseline to the follow-up serum creatinine measurements (range 0.52–5.75 years). Outcomes were defined, as in previous published work from the eGFR Study [ 4 , 13 , 14 , 16 ], as follows; 1) the annual eGFR decline as annual change in CKD-EPI eGFR ([CKD-EPI eGFR at follow up-CKD-EPI eGFR at baseline]/follow up period) and 2) the combined renal outcome defined as the first of the following: an absolute 30% decline in eGFR with a follow-up eGFR < 60 mL/min/1.73 m 2 , death from renal causes, or initiation of renal replacement therapy. All deaths occurring when eGFR declined to < 15 mL/min/1.73 m 2 were defined as renal deaths.…”

“…The laboratory and clinical measurements methods were described elsewhere in the previous work from the eGFR Study [ 4 , 11 , 13 , 14 , 16 ]. In summary, at baseline and follow-up, non-fasting venous blood samples were collected, and pathology and clinical records were reviewed.…”

“…Serum bilirubin concentration was positively associated with haemoglobin and total cholesterol; however there was an inverse association with UACR [ 9 ]. Cardiometabolic risk factors were not strong predictors for eGFR decline in Indigenous Australians who had normoalbuminuria at baseline [ 16 ].…”

Association of Baseline Concentrations of Liver Function Tests and Full Blood Count Indices with Annual eGFR Decline and Renal Outcomes in Aboriginal and Torres Strait Islander People: The eGFR Follow- Up Study

“…The follow-up was the time from the date of baseline to the follow-up serum creatinine measurements (range 0.52-5.75 years). Outcomes were de ned, as in previous published work from the eGFR study [4,14,16,17], as follows; 1) the annual eGFR decline as annual change in CKD-EPI eGFR ([CKD-EPI eGFR at follow up-CKD-EPI eGFR at baseline]/follow up period) and 2) the combined renal outcome de ned as the rst of the following: an absolute 30% decline in eGFR with a follow-up eGFR < 60 mL/min/1.73 m 2 , death from renal causes, or initiation of renal replacement therapy. All deaths occurring when eGFR declined to < 15 mL/min/1.73 m 2 were de ned as renal deaths.…”

Baseline liver function tests and full blood count indices and their association with progression of chronic kidney disease and renal outcomes in Aboriginal and Torres Strait Islander people: the eGFR Follow- up Study&nbsp;

“…The laboratory and clinical measurements methods were described elsewhere in the previous work from the eGFR Study [4,11,14,16,17]. In summary, at baseline and follow-up, non-fasting venous blood samples were collected, and pathology and clinical records were reviewed.…”