Contribution of ATP-Sensitive K+ Channels to Contraction of Rat Tail Artery is Significantly Reduced in Males but Not Females Rats in Streptozotocin-Induced Diabetes: Pharmacological Analysis
Abstract:Abstract:The aim of this article is to find out possible gender differences of participation of ATP-sensitive potassium channels in regulation of contractility in vascular smooth muscles of rats with diabetes.We used isolated tail artery of both genders rats with streptazotocin-induced diabetes (SID). After 3 weeks, we compared concentration-effects curves obtained with phenylephrine (0.1 to 300 μM) in the presence of 100 µM of diazoxid in control and SID rats of both genders.Diazoxide at 100 μM concentration … Show more
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