Contribution of antioxidant action of 7-chloro-4-(phenylselanyl)quinoline to treat streptozotocin-induced diabetic neuropathy in mice

Abstract

Hyperglycemia caused by diabetes mellitus contributes to complications such as diabetic neuropathy (DN), and its high prevalence and consequent economic costs make developing alternative therapies crucial. Given this scenario, this...

Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules

“…In view of these promising results, Wilhelm and co-workers [59] investigated possible modulation of oxidative stress by 34 in a neuropathic pain animal model. The target molecule was synthesized in 97% yield through the reaction of 4,7-dichloroquinoline 33 with organylselenols, generated in situ by the reaction of diphenyl diselenide 4c with aqueous H 3 PO 2 at 60 • C under N 2 atmosphere (Scheme 14).…”

“…Scheme 13. Synthesis of 6-organyl-5-(arylselanyl)benzo[h]quinolines 36.In view of these promising results, Wilhelm and co-workers[59] investigated possible modulation of oxidative stress by 34 in a neuropathic pain animal model. The target molecule was synthesized in 97% yield through the reaction of 4,7-dichloroquinoline 33…”