Abstract:Introduction In the last few years, pharmaceutical technology has evolved. In the field of oncology pharmacy, robots for the preparation of anti-cancer drugs have appeared to progressively replace manual preparation. The objective of this study is to evaluate the contribution of the robot in reducing the risk of manual preparation. Methods The study was conducted at the pharmacy of the National Institute of Oncology in Rabat (May–August 2021). The method used to compare the two types of preparation is the meth… Show more
“…Chemotherapy preparations are carried out in the pharmacy unit. 10,11 This study was conducted using a questionnaire (Appendix 1), and the first part included patient data such as: In the second part of the questionnaire, we were interested in the degree of compliance, in particular the patient's level of commitment and adherence to taking his or her treatment by means of the Morisky questionnaire. 12 The latter allowed us to evaluate the patient's level of compliance with his treatment through eight questions concerning the regularity or not of taking the tablets in different conditions and circumstances including travel, moving from home or during the improvement of apparent symptoms.…”
Section: Methodsmentioning
confidence: 99%
“…Chemotherapy preparations are carried out in the pharmacy unit. 10,11 This study was conducted using a questionnaire (Appendix 1), and the first part included patient data such as: Number order; Age; Gender; Comorbidities; The level of education of the respondent; and Cancer type.…”
Introduction Capecitabine is a molecule of choice in the therapeutic arsenal of anticancer drugs used in Morocco for the treatment of breast cancer and colorectal cancer. Its frequent use imposes a follow-up and a post-prescription monitoring of the treatment modalities as well as the adverse events that may occur following its administration. Objective The objective of this study is to evaluate the level of knowledge of patients in the day hospital of an oncology facility about their treatment with capecitabine. Materials and methods This is a prospective study conducted over a period of 2 months (January–February 2022) at the day hospital in the National Institute of Oncology in Rabat, and it was conducted using a questionnaire in order to evaluate patients’ knowledge about their treatment with capecitabine. Results This study involved 95 patients, 76% claimed to have ever received pharmaceutical advice on capecitabine treatment. The main indications were colorectal and breast cancer. Ninety seven percent knew the indication for capecitabine and the action of the molecule on the relevant tumor. Eighty three percent receiving capecitabine therapy reported the occurrence of side effects and hand-foot syndrome was the most reported in 31.2% of the total listed side effects. Discussion Capecitabine is an oral treatment of choice for colorectal and breast cancer in Morocco. Therapeutic education happens to be an effective tool in order to guarantee the best effectiveness and manage the possible side effects that can occur during the treatment.
“…Chemotherapy preparations are carried out in the pharmacy unit. 10,11 This study was conducted using a questionnaire (Appendix 1), and the first part included patient data such as: In the second part of the questionnaire, we were interested in the degree of compliance, in particular the patient's level of commitment and adherence to taking his or her treatment by means of the Morisky questionnaire. 12 The latter allowed us to evaluate the patient's level of compliance with his treatment through eight questions concerning the regularity or not of taking the tablets in different conditions and circumstances including travel, moving from home or during the improvement of apparent symptoms.…”
Section: Methodsmentioning
confidence: 99%
“…Chemotherapy preparations are carried out in the pharmacy unit. 10,11 This study was conducted using a questionnaire (Appendix 1), and the first part included patient data such as: Number order; Age; Gender; Comorbidities; The level of education of the respondent; and Cancer type.…”
Introduction Capecitabine is a molecule of choice in the therapeutic arsenal of anticancer drugs used in Morocco for the treatment of breast cancer and colorectal cancer. Its frequent use imposes a follow-up and a post-prescription monitoring of the treatment modalities as well as the adverse events that may occur following its administration. Objective The objective of this study is to evaluate the level of knowledge of patients in the day hospital of an oncology facility about their treatment with capecitabine. Materials and methods This is a prospective study conducted over a period of 2 months (January–February 2022) at the day hospital in the National Institute of Oncology in Rabat, and it was conducted using a questionnaire in order to evaluate patients’ knowledge about their treatment with capecitabine. Results This study involved 95 patients, 76% claimed to have ever received pharmaceutical advice on capecitabine treatment. The main indications were colorectal and breast cancer. Ninety seven percent knew the indication for capecitabine and the action of the molecule on the relevant tumor. Eighty three percent receiving capecitabine therapy reported the occurrence of side effects and hand-foot syndrome was the most reported in 31.2% of the total listed side effects. Discussion Capecitabine is an oral treatment of choice for colorectal and breast cancer in Morocco. Therapeutic education happens to be an effective tool in order to guarantee the best effectiveness and manage the possible side effects that can occur during the treatment.
“…12 At the National Institute of Oncology (INO), the preparation of injectable chemotherapies can be performed through manual preparation and can also be automated via the Pharmoduct ® robot. 13,14…”
Introduction Personnel involved in the preparation of cytotoxics are exposed to them and the resulting risks. To protect themselves, many means of protection are currently implemented. Nevertheless, the exposure of these manipulators remains a possibility to be considered. Materials and methods The study was conducted during the period (October–November 2022) in the pharmacy of the National Institute of Oncology (INO), a hospital structure specializing in cancer care. The Failure Mode, Effects and Criticality Analysis method was used to assess the risks of exposure of personnel in a central cytotoxic preparation unit and then calculate the criticality index (CI = severity × frequency × detectability). The risks were classified into toxic, traumatic, chemical, and environmental risks. We have cited 12 failure modes of which nine are minor and three are major. The three major modes cited are essentially related to the particulate environment, direct contact and daily passive inhalation of handling. Conclusion Our study shows that in our institution, the analysis of the risk of exposure of personnel to cytotoxics remains important, hence the interest of automaton in charge of preparations and which will gradually take charge of all the preparations. The existing procedures and the pharmacotechnical equipment used also contribute to protection and risk reduction.
Objective Chemotherapy medications are usually having high costs, and new targeted drugs can be especially expensive, representing a challenge on healthcare, particularly in low- and middle-income countries. As cytotoxic leftover management is crucial for reducing medication wastage, the aim of this study is to evaluate and optimize leftover management circuit in NIO’S Pharmacy Centralized Chemotherapy Preparation Unit (CCPU) through a Failure Mode, Effects and Criticality Analysis (FMECA), and propose continuous improvement element to enhance the security of the process. Method The FMECA were conducted in NIO’s CCPU from March to May 2023, then continuous improvement plan was established to enhance the security of the process. The failure modes, their causes, impact, and criticality were assessed through criticality index calculation (CI = severity × frequency × detectability), and the risk concerned safety and effectiveness disruptions in chemotherapy preparation circuit using cytotoxic leftover. Results Leftover management circuits were described in flowchart form, where 18 failure modes were detected in four different steps of the process from chemotherapy preparation to disposal. Failure with highest critical index were detected in the case of equipment malfunction, improper storage temperature, and humidity. Continuous improvement recommendations were proposed in a table form. Conclusion FMECA analysis applied to NIO’s chemotherapy leftover management process allowed us to evaluate, secure, and optimize the circuit, and to propose several actions to implement in a perspective of continuous improvement.
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