Contribution of (1→3)-β-
            <scp>d</scp>
            -Glucan Chromogenic Assay to Diagnosis and Therapeutic Monitoring of Invasive Aspergillosis in Neutropenic Adult Patients: a Comparison with Serial Screening for Circulating Galactomannan

Pazos, Carmen; Pontón, José; Palacio, Amalia del

doi:10.1128/jcm.43.1.299-305.2005

Cited by 314 publications

(256 citation statements)

References 33 publications

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“…Its presence in serum and normally sterile body fluids is a marker of IFD and is an indirect mycological criterion in the revised definitions of IFD (4). Different studies have established its diagnostic value in invasive candidiasis and invasive aspergillosis (9,10). However, currently numerous non-Candida and non-Aspergillus fungi are important causes of IFD in the immunocompromised host, and in this setting, clinical and mycological experience with the use of BG as a tool for diagnosis is scarce (7)(8)(9)(10)(11).…”

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confidence: 99%

Detection of (1→3)-β- d -Glucan as an Adjunct to Diagnosis in a Mixed Population with Uncommon Proven Invasive Fungal Diseases or with an Unusual Clinical Presentation

Cuétara

Alhambra

Moragues

et al. 2009

Clin Vaccine Immunol

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This single-center observational prospective study evaluated the performance of (1→3)-β-d-glucan as an adjunct diagnostic tool in 12 patients with proven invasive fungal disease with different risk factors. The infections were due to either uncommon fungal pathogens such as dematiaceous molds (Scedosporium apiospermum, Alternaria infectoria, and Cladosporium macrocarpum) and hyaline septate molds (Fusarium solani and Blastoschizomyces capitatus) or Aspergillus spp. with unusual clinical presentations.

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confidence: 99%

Detection of (1→3)-β- d -Glucan as an Adjunct to Diagnosis in a Mixed Population with Uncommon Proven Invasive Fungal Diseases or with an Unusual Clinical Presentation

Cuétara

Alhambra

Moragues

et al. 2009

Clin Vaccine Immunol

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“…Molecular tests like aspergillus galactomannan, 13-b-glucan, and aspergillus polymerase chain reaction aide the diagnosis. 65,[68][69][70] Antifungal therapy for aspergillus should be started early as soon as there is a clinical suspicion. For treatment of invasive aspergillosis, voriconazole is the drug of choice.…”

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confidence: 99%

Hepatobiliary Quiz Answers—19 (2016)

Rathi

Dhiman

2016

Journal of Clinical and Experimental Hepatology

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“…62 A combination of the GM and BG can be useful for identifying false-positive reactions. 63 A specific Aspergillus PCR assay has also been used to diagnose invasive aspergillosis (100% sensitivity and 89% specificity). Quantitative real-time PCR for diagnosing invasive aspergillosis has shown sensitivity and specificity values of 67% and 100%, respectively, and can be used to monitor response to treatment.…”

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confidence: 99%

Infections After Orthotopic Liver Transplantation

Pedersen

Seetharam

2014

Journal of Clinical and Experimental Hepatology

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Opportunistic infections are a leading cause of morbidity and mortality after orthotopic liver transplantation. Systemic immunosuppression renders the liver recipient susceptible to de novo infection with bacteria, viruses and fungi post-transplantation as well to reactivation of pre-existing, latent disease. Pathogens are also transmissible via the donor organ. The time from transplantation and degree of immunosuppression may guide the differential diagnosis of potential infectious agents. However, typical systemic signs and symptoms of infection are often absent or blunted after transplant and a high index of suspicion is needed. Invasive procedures are often required to procure tissue for culture and guide antimicrobial therapy. Antimicrobial prophylaxis reduces the incidence of opportunistic infections and is routinely employed in the care of patients after liver transplant. In this review, we survey common bacterial, fungal, and viral infections after orthotopic liver transplantation and highlight recent developments in their diagnosis and management. ( J CLIN EXP HEPATOL 2014;4:347-360) I nfection after orthotopic liver transplantation (OLT) is a major cause of morbidity and mortality. Infection is estimated to occur in upto 80% of organ recipients. Bacterial infections are most frequent (70%), followed by viral (20%) and fungal infections (8%). 1,2,3 In addition to direct effects of infection and end-organ inflammation, pathogens may have a number of indirect effects that result in allograft injury, rejection and opportunistic superinfection.The risk of infection in liver transplant recipients is determined by the intensity of exposure to infectious agents and the overall level of immunosuppression. 4 In addition, conditions attendant to end-stage liver disease in the immediate perioperative period may render a recipient vulnerable to infection and include: neutropenia, deficits in mucocutaneous barrier integrity, presence of necrotic tissue, ischemia, diabetes mellitus, immunomodulating viruses, uremia, and protein-calorie malnutrition. 5 Infectious exposures come from many sources post liver transplant including: de novo (acquired acute) in the recipient, reactivation in the recipient, the donor organ, and nosocomial and time from transplant may provide clues to etiology (Figure 1). The overall level of immunosuppression is dependent upon the dose, duration, and choice of immunosuppression as well as underlying immune deficiencies. 6 Inflammatory responses to invading pathogens are often blunted by immunosuppressive therapy, and as a result, the classic signs or symptoms of infection may be absent. A high index of suspicion is need in the liver recipient, and a low threshold to perform invasive diagnostic procedures is often required. It is critical to identify clinical factors that predispose recipients to infection and much interest centers on identifying risk factors for infection after liver transplant. GENETIC POLYMORPHISMS IN THE INNATE IMMUNE SYSTEMIn addition to clinical factors that promote ...

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Contribution of (1→3)-β- d -Glucan Chromogenic Assay to Diagnosis and Therapeutic Monitoring of Invasive Aspergillosis in Neutropenic Adult Patients: a Comparison with Serial Screening for Circulating Galactomannan

Cited by 314 publications

References 33 publications

Detection of (1→3)-β- d -Glucan as an Adjunct to Diagnosis in a Mixed Population with Uncommon Proven Invasive Fungal Diseases or with an Unusual Clinical Presentation

Detection of (1→3)-β- d -Glucan as an Adjunct to Diagnosis in a Mixed Population with Uncommon Proven Invasive Fungal Diseases or with an Unusual Clinical Presentation

Hepatobiliary Quiz Answers—19 (2016)

Infections After Orthotopic Liver Transplantation

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