Contributing factors to changes of cerebral blood flow in major depressive disorder

Ohgami, Hirochika; Nagayama, Haruo; Akiyoshi, Jotaro; Tsuchiyama, Kounosuke; Komaki, Shogo; Takaki, Haruyuki; Mori, Hiromu

doi:10.1016/j.jad.2005.03.004

Cited by 11 publications

(3 citation statements)

References 31 publications

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“…Although functional imaging studies on normal subjects had shown age-related rCBF impairment (Krausz et al, 1998), few investigations of the rCBF in MDD patients considered the effects of age (Nagafusa et al, 2012;Ohgami et al, 2005). Because there was a wide age distribution in our patients (from 28 to 73 years) and a significant correlation between their age and the rCBF in some regions, we used age as one of the covariates in our comparison of the T1 rCBF in MDD patients and the controls.…”

Section: Tablementioning

confidence: 99%

Changes in the regional cerebral blood flow detected by arterial spin labeling after 6-week escitalopram treatment for major depressive disorder

Kaichi

Okada

Takamura

et al. 2016

Journal of Affective Disorders

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Section: Tablementioning

confidence: 99%

Changes in the regional cerebral blood flow detected by arterial spin labeling after 6-week escitalopram treatment for major depressive disorder

Kaichi

Okada

Takamura

et al. 2016

Journal of Affective Disorders

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“…Changes in rCBF during and after treatment have been documented. Previously using 99m Tc-hexamethyl-propylene-amine oxime ( 99m Tc-HMPAO) brain SPECT have shown rCBF changes involved: Global cerebral blood flow (CBF) decreased,[ 13 ] left frontal CBF decreased,[ 3 ] CBF decreased both in the left and right anterior frontal[ 14 ] and in temporal lobe,[ 7 ] as well as in thalamus, right posterior cingulate, right parietal cortex, and right caudate nucleus[ 15 ] in depressed patients when compared with normal controls.…”

Section: Discussionmentioning

confidence: 99%

Changes in regional cerebral blood flow with Chaihu-Shugan-San in the treatment of major depression

et al. 2014

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Background:Chaihu-Shugan-San (CHSGS) is a well-known Chinese traditional prescription used for depression.Objective:To observe the regional cerebral blood flow (rCBF) changes in patients with major depression and to investigate rCBF and clinical response to CHSGS.Materials and Methods:A total of 33 unmedicated patients with major depression and 12 healthy comparison subjects underwent single photon emission computed tomography (SPECT) imaging. A total of 33 unmedicated patients with major depression all met the diagnostic criteria of stagnation of liver qi of traditional Chinese medicine and were divided into two groups: CHSGS group (n = 20) and fluoxetine group (n = 13). SPECT imaging was restudied in posttreatment.Results:SPECT detected abnormalities in all (100.0%) patients both in CHSGS group and fluoxetine group. All healthy subjects were normal results. The depressed patients showed rCBF decreased in the multiple regions. The semiquantitative values of bilateral frontal and left temporal lobes both in CHSGS group and fluoxetine group were lower than that in healthy group (P < 0.05). Reexamined SPECT after 8 weeks treatment with CHSGS showed the consistency between the increase in perfusion defects and the improvement of clinical cerebral symptoms. The semiquantitative values increased in posttreatment, when compared with pretreatment (P < 0.05).Conclusion:SPECT represents a sensitive tool to detect the major depressive disorder, which show the rCBF decreased. rCBF perfusion defects can be reversed and clinical symptoms can be improved by CHSGS treatment. CHSGS treatment is effective, well-tolerated, and safe for depression. By semiquantitative analysis, SPECT can objectively detect rCBF changes that is useful for guiding treatment.

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“…DSC-MRI perfusion estimates are generally regarded to be reliable in relative terms, but both CBF and CBV values have tended to be overestimated [1]. Although relative maps of perfusion and perfusion-related parameters are often sufficient, there are applications for which absolute values are warranted, for example for diagnostics and follow-up of patients with stroke, intracranial tumour, dementia and depression [2][3][4][5][6]. One feasible approach to obtain reliable absolute values is to measure CBV with a complementary method that provides absolute values, either globally or locally, and to compare these values with the corresponding DSC-MRI CBV estimates to determine a calibration factor (CF).…”

Section: Introductionmentioning

confidence: 99%

Absolute quantification of perfusion by dynamic susceptibility contrast MRI using Bookend and VASO steady-state CBV calibration: a comparison with pseudo-continuous ASL

Lindgren

Wirestam

Bloch

et al. 2014

Magn Reson Mater Phy

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General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal AbstractObjective: Dynamic susceptibility-contrast MRI (DSC-MRI) tends to return elevated estimates of cerebral blood flow (CBF) and cerebral blood volume (CBV). In this study, subject-specific calibration factors (CFs), based on steady-state CBV measurements, were applied to rescale the absolute level of DSC-MRI CBF. Materials and Methods:Twenty healthy volunteers were scanned in a test-retest approach. Independent CBV measurements, for calibration, were accomplished using a T1-based contrast agent steady-state method (referred to as Bookend) as well as a blood-nulling vascular space occupancy (VASO) approach. Calibrated DSC-MRI was compared with pseudo-continuous arterial spin labeling (pCASL).Results: For segmented grey matter (GM) regions of interests (ROIs), pCASL-based CBF was 63±11 ml/(min100g) (mean±SD). Nominal CBF from non-calibrated DSC-MRI was 277±61 ml/(min100g), while calibrations resulted in 56±23 ml/(min100g) (Bookend) and 52±16 ml/(min100g) (VASO). Calibration tended to eliminate the overestimation, although the repeatability was, generally, moderate and the correlation between calibrated DSC-MRI and pCASL was low (r<0.25). However, using GM instead of WM ROIs for extraction of CFs resulted in improved repeatability. Conclusion:Both calibration approaches provided reasonable absolute levels of GM CBF, although the calibration methods suffered from low signal-to-noise ratio, resulting in weak repeatability and difficulties in showing high degrees of correlation with pCASL measurements.3

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Contributing factors to changes of cerebral blood flow in major depressive disorder

Cited by 11 publications

References 31 publications

Changes in the regional cerebral blood flow detected by arterial spin labeling after 6-week escitalopram treatment for major depressive disorder

Changes in the regional cerebral blood flow detected by arterial spin labeling after 6-week escitalopram treatment for major depressive disorder

Changes in regional cerebral blood flow with Chaihu-Shugan-San in the treatment of major depression

Absolute quantification of perfusion by dynamic susceptibility contrast MRI using Bookend and VASO steady-state CBV calibration: a comparison with pseudo-continuous ASL

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