2022
DOI: 10.22541/au.165494170.08151812/v1
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Contributing factors on metabolic mechanism-based CYP3A4-activated/deactivated anticancer drugs: implications for individualizing chemotherapy

Abstract: Cytochrome P450 3A4 (CYP3A4), one of important members of the cytochrome P450 subfamily, acts as a critical catalyst for multiple drug metabolism. Pharmacological activities and clinical outcomes of CYP3A4-metabolized anticancer drugs greatly depend on this enzyme activity and expression, as it catalyzes a variety of reactions for drug activation or inactivation. In view of the complex tumor environments as well as various factors concerning CYP3A4 expression, function, and regulation such as physiological fac… Show more

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