IT IS universally taught that the ultimate danger of digitalis poisoning is ventricular fibrillation, yet a careful search of the literature discloses very few clinical cases with electrocardiographic proof. In this communication the subject will be briefly reviewed, and 2 additional cases will be described. Both of our cases were attributable to acetyl strophanthidin, a synthetic ester of the cardiac aglycone strophanthidin.' This new drug acts with unusual speed after intravenous administration, producing early effects in a very few minutes and peak effects within a quarter hour; the duration of action being less than four hours.2'3