Contribución al conocimiento de los reservorios del Trypanosoma cruzi (Chagas,1909) en la Provincia de Corrientes, Argentina

Bar, María Esther; Alvarez, Benedicta Mabel; Oscherov, Elena Beatriz; Damborsky, Miryam Pieri; Jorg, M.E

doi:10.1590/s0037-86821999000300008

Cited by 14 publications

(12 citation statements)

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“…T. cruzi-like trypanosomes were early reported infecting Cebus apella by Carvalheiro & Barretto (1966) in woodland from the São Paulo Estate, Brazil. Bar et al (1999) found 3.8% of infection in this primate species in Corrientes, Argentine Chaco. Jansen et al (2015) also described specimens of Cebus spp.…”

Section: Discussionmentioning

confidence: 65%

First report of Sapajus cay naturally infected by Trypanosoma cruzi in San Pedro Department, Paraguay

Acosta

Miret

López

et al. 2016

Rev. Bras. Parasitol. Vet.

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To verify the occurrence of natural Trypanosoma cruzi infection in non-human primates from a rural endemic area of the east region of Paraguay, xenodiagnosis was performed in 35 animals belonging to two species. For genotyping and T. cruzi discrete typing unit (DTU) assignment, a combination of four markers was used, including amplification products of the small (18S) and large (24Sα) subunits of ribosomal ribonucleic acid gene, the intergenic region of mini-exon gene and the heat shock protein 60 Eco-RV polymerase chain reaction-restriction fragment length polymorphism (HSP60/EcoRV-PCR-RFLP). One specimen of Sapajus cay was found positive and infected by the DTU TcII. This result constitutes the first record of natural T. cruzi infection in a sylvatic monkey in Paraguay, harbouring a DTU associated with severe Chagas disease in humans.Keywords: Trypanosoma cruzi, primates, Paraguay. ResumoCom o objetivo de verificar a infecção natural por Trypanosoma cruzi em primatas não-humanos de uma área endêmica rural da região leste do Paraguai, foi realizado o xenodiagnóstico em 35 animais pertencentes a duas espécies. Para a genotipagem foi utilizada a unidade discreta de tipagem (UDT) do T. cruzi, em uma combinação de quatro marcadores, incluindo amplificação de produtos de pequena (18S) e grande (24Sα) subunidades do gene do ácido ribonucleico ribossômico, da região intergênica de miniéxon e do gene da proteína de choque térmico 60 (HSP60/ EcoRV-PCR-RFLP), pela reação em cadeia da Polimerase. Um espécime de Sapajus cay se mostrou positivo pelo UDT TcII. Este resultado constitui o primeiro relato da infecção natural pelo T. cruzi em um macaco silvestre no Paraguai, abrigando um UDT associado com a doença de Chagas grave em humanos.Palavras-chave: Trypanosoma cruzi, primatas, Paraguai.

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Section: Discussionmentioning

confidence: 65%

First report of Sapajus cay naturally infected by Trypanosoma cruzi in San Pedro Department, Paraguay

Acosta

Miret

López

et al. 2016

Rev. Bras. Parasitol. Vet.

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“…In light of this, a better understanding of the epidemiology of T. cruzi in the wild can improve knowledge of the risk of new cases of Chagas disease in humans and other mammal species. Studies of the epidemiology of T. cruzi in freeranging mammals have been mainly restricted to crosssectional studies (Bar et al 1999;de Thoisy et al 2000;Dereure et al 2001). A better understanding of the transmission cycle of parasites in the wild is only possible through longitudinal studies, which typically are expensive, difficult to carry out, and time consuming.…”

Section: Introductionmentioning

confidence: 99%

Parasite community interactions: Trypanosoma cruzi and intestinal helminths infecting wild golden lion tamarins Leontopithecus rosalia and golden-headed lion tamarins L. chrysomelas (Callitrichidae, L., 1766)

et al. 2007

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The parasite prevalence and infection intensity in primate wild populations can be affected by many variables linked to host and/or parasite ecology or either to interparasite competition/mutualism. In this study, we tested how host sex, age, and place of origin, as well parasitic concomitant infections affect the structure of golden lion and golden-headed lion tamarins parasite community, considering Trypanosoma cruzi and intestinal helminths infection in these primates. A total of 206 tamarins from two Atlantic Coastal rain forest areas in Brazil were tested during 4 years for prevalence of T. cruzi infection and helminth prevalence. Three intestinal helminth groups showed high prevalences in both tamarin species: Prosthenorchis sp., Spiruridae, and Trichostrongylidae. An association between presence of T. cruzi infection and higher intestinal helminth prevalence was found in both tamarin species. Two explanations for this association seem to be plausible: (1) lower helminth-linked mortality rates in T. cruzi-infected tamarins and (2) lower elimination rates of helminths in such tamarins. A higher frequency of T. cruzi-positive blood cultures was significantly correlated to female tamarins and to the presence of Trichostrongylidae infection. The possibility of an increase in the transmissibility of T. cruzi and the three analyzed helminths in lion tamarins with concomitant infections is discussed.

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“…In a dry section of Chaco province, T. cruzi infections were frequently documented in D. albiventris (35.7%) but not in armadillos examined by xenodiagnosis (Diosque et al, 2004). More recent, small-sized surveys in eastern Paraguay and northeastern Argentina detected no T. cruzi -infected opossum using xenodiagnosis and/or PCR (Bar et al, 1999; Yeo et al, 2005). Our review indicates that few surveys of T. cruzi infection in sylvatic mammals have been conducted in the Gran Chaco, especially in the humid section, and that opossum infections with T. cruzi are widespread and widely variable over time and space.…”

Section: Discussionmentioning

confidence: 98%

The sylvatic transmission cycle of Trypanosoma cruzi in a rural area in the humid Chaco of Argentina

Alvarado-Otegui¹,

Ceballos²,

Orozco³

et al. 2012

Acta Tropica

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Little is known about the sylvatic transmission cycle of Trypanosoma cruzi in the Gran Chaco ecoregion. We conducted surveys to identify the main sylvatic hosts of T. cruzi, parasite discrete typing units and vector species involved in Pampa del Indio, a rural area in the humid Argentinean Chaco. A total of 44 mammals from 14 species was captured and examined for infection by xenodiagnosis and polymerase chain reaction amplification of the hyper-variable region of kinetoplast DNA minicircles of T. cruzi (kDNA-PCR). Ten (22.7%) mammals were positive by xenodiagnosis or kDNA-PCR. Four of 11 (36%) Didelphis albiventris (white-eared opossums) and six of nine (67%) Dasypus novemcinctus (nine-banded armadillos) were positive by xenodiagnosis and or kDNA-PCR. Rodents, other armadillo species, felids, crab-eating raccoons, hares and rabbits were not infected. Positive animals were highly infectious to the bugs that fed upon them as determined by xenodiagnosis. All positive opossums were infected with T. cruzi I and all positive nine-banded armadillos with T. cruzi III. Extensive searches in sylvatic habitats using 718 Noireau trap-nights only yielded Triatoma sordida whereas no bug was collected in 26 light-trap nights. Four armadillos or opossums fitted with a spool-and-line device were successfully tracked to their refuges; only one Panstrongylus geniculatus was found in an armadillo burrow. No sylvatic triatomine was infected with T. cruzi by microscopical examination or kDNA-PCR. Our results indicate that two independent sylvatic transmission cycles of T. cruzi occur in the humid Chaco. The putative vectors of both cycles need to be identified conclusively.

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Contribución al conocimiento de los reservorios del Trypanosoma cruzi (Chagas,1909) en la Provincia de Corrientes, Argentina

Abstract: Resumen Con el propósito de identificar a reservorios del

Cited by 14 publications

References 4 publications

First report of Sapajus cay naturally infected by Trypanosoma cruzi in San Pedro Department, Paraguay

First report of Sapajus cay naturally infected by Trypanosoma cruzi in San Pedro Department, Paraguay

Parasite community interactions: Trypanosoma cruzi and intestinal helminths infecting wild golden lion tamarins Leontopithecus rosalia and golden-headed lion tamarins L. chrysomelas (Callitrichidae, L., 1766)

The sylvatic transmission cycle of Trypanosoma cruzi in a rural area in the humid Chaco of Argentina

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