Contrasting the efficacy of pulsed dye laser and photodynamic methylene blue nanoemulgel therapy in treating acne vulgaris

Soliman, Mona; Salah, Manal; Fadel, Maha; Nasr, Maha; El-Azab, Heba

doi:10.1007/s00403-020-02093-y

Cited by 15 publications

(8 citation statements)

References 38 publications

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“…There was a significant difference in the number of acne lesions after therapy between the two groups. 11,[24][25][26] The use of topical photosensitizers has the potential to enhance the effects of light-based therapy. Endogenous photodynamic therapy (PDT) using different light sources has been shown in clinical trials to be effective for the treatment of mild to moderate inflammatory acne by acting against porphyrins produced by bacteria (Propionibacterium acne) alone.…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness of Pulsed Dye Laser in Management of Acne Vulgaris: A Systematic review and meta-analysis

2021

AJODRR

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Background: Acne vulgaris is one of the most prevalent skin diseases, affecting up to 85% of teenagers and young adults. Multiple treatment options including topical, systemic or physical therapies. However, the effects of conventional therapies are limited due to antibi-otic resistance and adverse effects such as irritation and teratogenicity of isotretinoin. Light-based therapy is an alternative and/or adjuvant therapy in patients who cannot tolerate or unresponsive to conventional therapies that may provide fewer side effects, patient com-fort, fast onset of action, and with equal or greater effectiveness. We aimed to assess the effectiveness of using Pulsed Dye Laser as a treatment option for acne vulgaris. A systemat-ic Review and Meta-analysis was peformed of randomized clinical trials assessing the ef-fectiveness of Pulsed Dye Laser in management of acne vulgaris. Methods: Medline Pubmed, Scopus, Cochrane library, the reference list, conference pro-ceedings, researchers in field of eligible studies were searched. Eight studies (n=275 sub-jects) were included in qualitative analysis of which six studies (n=190 subjects) were in-cluded in meta-analysis. The mean age of the participant was 21,94 years old. Intervention using application of Pulsed dye laser as monotherapy or combination in acne vulgaris pa-tients with follow-up at least 12 weeks. and the outcomes is a decrease mean of acne vul-garis lesions counts after received pulsed dye laser therapy. Results: Pooling of data using random effects model showed that the group that received PDL therapy alone or in combination had a lower number of acne lesions than the control group with the mean difference was -0.593 (95% CI = -1.290 to 0.104), the z value was -1.668 with p = 0.095. This shows that the number of lesions in the group that received sin-gle or combined PDL therapy was lower than the control group. However the difference is insignificant. Conclusion. From the results of the systematic review conducted, it can be concluded that in the group given Pulsed Dye Laser therapy there was a decrease in the total number of acne vulgaris lesions compared to before treatment, and the decrease, which was indicated by the difference in the mean number of acne lesions, was significantly greater compared to the control who was only given placebo. Pulsed Dye Laser therapy can be an alternative treatment option for acne vulgaris in patients who are unresponsive to previous treatment or conditions where there are contraindications to systemic therapy.

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Section: Discussionmentioning

confidence: 99%

The Effectiveness of Pulsed Dye Laser in Management of Acne Vulgaris: A Systematic review and meta-analysis

2021

AJODRR

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“…Lasers have also been evaluated in accordance with topical agents for treating PIH. Due to the wide absorptive spectrum of melanin, it is challenging to identify optimal lasers for darker skin while minimizing the side effects such as hyperpigmentation, pain, blistering, and scarring 23‐25 A study evaluating the use of low‐fluence Q switched Nd:YAG laser (QSNYL) in 40 Korean patients with Fitzpatrick skin types III‐IV suffering from melasma demonstrated a 54% decrease in hyperpigmentation and minimum side effects 26 . Another study evaluating the efficacy of lasers in the treatment of melasma with 75 Indian patients, Fitzpatrick skin types IV‐V, randomly assigned patients into three treatment groups: low‐fluence QSNYL, high‐fluence QSNYL, and GA peels 27 …”

Section: Managementmentioning

confidence: 99%

“…Treatment options for post-inflammatory hyperpigmentation in skin of color. is challenging to identify optimal lasers for darker skin while minimizing the side effects such as hyperpigmentation, pain, blistering, and scarring[23][24][25] A study evaluating the use of low-fluence Q switched Nd:YAG laser (QSNYL) in 40 Korean patients with Fitzpatrick skin types III-IV suffering from melasma demonstrated a 54% decrease in hyperpigmentation and minimum side effects 26. Another study evaluating the efficacy of lasers in the treatment of melasma with 75 Indian patients, Fitzpatrick skin types IV-V, randomly assigned patients into three treatment groups: low-fluence QSNYL, high-fluence QSNYL, and GA peels.27 The study concluded that there was significant improvement in the low-fluence QSNYL group as compared to the high-fluence group and the GA group, with the low-fluence QSNYL group having the fewest adverse events.…”

mentioning

confidence: 99%

Management of post‐inflammatory hyperpigmentation in skin of color: A short review

Anvery

Christensen

Dirr

2022

J of Cosmetic Dermatology

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Post‐inflammatory hyperpigmentation (PIH) is a common cosmetic complaint affecting patient quality of life. PIH has been proven to disproportionately affect skin of color. While several treatment options exist, special consideration must be given when managing PIH in patients of color, as topical treatments and aesthetic procedures, such as chemical peels and lasers, may either exacerbate or prove ineffective against PIH.

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“…MB PDT was applied to treat truncal and facial acne vulgaris, a chronic inflammatory disease of the pilosebaceous unit that has multiple pathophysiological factors [88][89][90]. The topical and oral treatments currently available for acne vulgaris have a limited effect, particularly in mild to moderate cases [91].…”

Section: Methylene Blue-based Photodynamic Therapymentioning

confidence: 99%

“…By targeting some of the main pathophysiological factors, topical PDT application may reduce inflammation associated with acne lesions in areas of the body which are difficult to reach with conventional therapy [92]. To overcome the problem of inadequate penetration of photosensitizers into the skin during topical treatment with PDT, nanocarriers containing MB have been developed [88][89][90]. MB has a high affinity for melanin, making this particularly relevant to pigmented cancer tissues in melanoma lesions [93,94].…”

Section: Methylene Blue-based Photodynamic Therapymentioning

confidence: 99%

Clinical effectiveness and prospects of methylene blue: A systematic review

Seitkazina¹,

Yang²,

Kim³

2022

Precis Future Med

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Methylene blue (MB) is a well-known pharmaceutical ingredient that is thought to have a multi-targeted therapeutic effect as an anti-malarial and neuroprotective agent and has recently been identified as a treatment for coronavirus disease 2019 . In this review, we present an overview of relevant clinical trials, including ongoing trials, on the therapeutic uses of MB. A search for clinical trials on clinicaltrials.gov was performed using the terms "methylene blue" and "methylthionine chloride." This review focuses on clinical trials of MB-based therapies applied to brain diseases, cancer imaging and diagnosis, infectious diseases such as malaria or COVID-19, and cardiovascular diseases. Nanoparticle-based delivery techniques have also been briefly discussed in addition to common delivery methods.

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Contrasting the efficacy of pulsed dye laser and photodynamic methylene blue nanoemulgel therapy in treating acne vulgaris

Cited by 15 publications

References 38 publications

The Effectiveness of Pulsed Dye Laser in Management of Acne Vulgaris: A Systematic review and meta-analysis

The Effectiveness of Pulsed Dye Laser in Management of Acne Vulgaris: A Systematic review and meta-analysis

Management of post‐inflammatory hyperpigmentation in skin of color: A short review

Clinical effectiveness and prospects of methylene blue: A systematic review

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