“…Mutations have been reported in the genes encoding KDM5A (JARID1A); KDM5C (JARID1C), which affects H3K4 methylation; and KDM6A (UTX), which affects H3K27 methylation. 50,81,82,98,105,106 UTX (KDM6A) and JMJD3 (KDM6B) Besides EZH2 methyltransferase, H3K27 methylation is also determined by the activity of demethylases, including UTX/ KDM6A and JMJD3/KDM6B. Somatic loss-of-function mutations of UTX are found in multiple myeloma, esophageal squamous cell carcinomas, renal carcinomas, and occasionally in breast cancer, AML, T-ALL, GBM, and colorectal and bladder cancer (Table 1) (for review see.…”