Contrasting Role of Fungal Siderophore in Metal Ion Complex Formation

Bhardwaj, Snigdha; Singh, Shaminder; Bhatia, Sonam

doi:10.1007/978-3-030-53077-8_7

Cited by 2 publications

(1 citation statement)

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“…This receptor-AHL complex acts as transcriptional modifiers of target genes in the QS region and controls the expression of virulent gene as well as induction of biofilm formation. [3][4] Two different QS circuit have been observed in P. aeruginosa. These circuits are genetically similar containing genes that encodes for transcriptional activator proteins (LasR and RhlR) and also genes involved in the production of AHL signaling molecules (lasI and rhlI).…”

Section: Introductionmentioning

confidence: 99%

Virtual Screening of Potential Quorum Sensing Inhibitors of P. aeruginosa

Bhardwaj

Gupta

2022

IJPI

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Background: Pseudomonas aeruginosa (P. aeruginosa) is considered as one of the most opportunistic pathogens that may infect humans and led to increase in bacterial virulence or pathogenicity. P. aeruginosa exhibits variety of virulence factors and their rate of expression are associated with cell-to-cell communication process also known as quorum sensing (QS). LasR, a transcriptional factor which regulates the process of QS in P. aeruginosa is known as attractive drug target. Materials and Methods:The research work involves identification of putative inhibitors of LasR by molecular docking approach. Total 60 compounds were docked in the active site of LasR and CviR protein, followed by subsequent screening based on Lipinski's rule of five, Veber rule and molar refractivity. Results: Out of 60 compounds, total seven novel compounds were selected on the basis of binding energies (docking score> 10). Structures of LasRinhibitor complexes were analyzed to have vital insights from the binding between LasR and inhibitor molecules. The selected compounds were analyzed for physico-chemical properties and drug likeness to establish correlation between oral bioavailability and pharmacokinetics of compound. Conclusion:The study revealed the potential of thiazole derivative as novel QSI and expedite the possibility to combat virulence of multi-drug resistant P. aeruginosa in more effective manner.

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Section: Introductionmentioning

confidence: 99%