Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in Aedes aegypti populations from Jacarezinho (Brazil) after a Dengue Outbreak

Aguirre-Obando, Oscar Alexander; Pietrobon, Anna Julia; Bona, Ana Caroline Dalla; Navarro-Silva, Mário Antônio

doi:10.1016/j.rbe.2015.11.009

Cited by 17 publications

(13 citation statements)

References 49 publications

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“…However, it has been stated that to rely only on adulticide is a risky decision [20]. The research in [6,7,21] supports this claim, citing the problem of Aedes aegypti mosquito's resistance to insecticide. Under the new achievement in the field of vaccination technology with the discovery of the first vaccine against dengue by Sanofi Pasteur, the work in [22] devised two models, one assuming that unintentional vaccination increases the infectious period and another assuming that unintentional vaccination leads to the development of symptoms.…”

Section: Journal Of Applied Mathematicsmentioning

confidence: 99%

“…(6) There is no recovered phase in mosquitoes due to their short lifespan [20]. (7) There is no resistant (immune) effect in mosquitoes to the use of synthetic fumigation, such as insecticides and larvicides [6,7]; in this article, we assume that there is no resistant (immunity) effect to mosquitoes due to use of synthetic fumigation, such as insecticide and larvicide.…”

Section: Mathematical Model Constructionmentioning

confidence: 99%

“…However, the long-term use of insecticides and larvicides poses several risks: one is resistance of the mosquito to the product, reducing its efficacy, while genetic mutation of the mosquito, making it less susceptible to the effects of the product, is another. Such products have also been linked to numerous adverse health effects including the worsening of asthma and respiratory problems [3,6]. In Surabaya, Indonesia, larval mortality rates of under 80% indicate possible resistance of 2…”

Section: Introductionmentioning

confidence: 99%

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Understanding Dengue Control for Short- and Long-Term Intervention with a Mathematical Model Approach

Bustamam

Aldila

Yuwanda

2018

Journal of Applied Mathematics

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A mathematical model of dengue diseases transmission will be discussed in this paper. Various interventions, such as vaccination of adults and newborns, the use of insecticides or fumigation, and also the enforcement of mechanical controls, will be considered when analyzing the best intervention for controlling the spread of dengue. From model analysis, we find three types of equilibrium points which will be built upon the dengue model. In this paper, these points are the mosquito-free equilibrium, disease-free equilibrium (with and without vaccinated compartment), and endemic equilibrium. Basic reproduction number as an endemic indicator has been found analytically. Based on analytical and numerical analysis, insecticide treatment, adult vaccine, and enforcement of mechanical control are the most significant interventions in reducing the spread of dengue disease infection caused by mosquitoes rather than larvicide treatment and vaccination of newborns. From short-and long-term simulation, we find that insecticide treatment is the best strategy to control dengue. We also find that, with periodic intervention, the result is not much significantly different with constant intervention based on reduced number of the infected human population. Therefore, with budget limitations, periodic intervention of insecticide strategy is a good alternative to reduce the spread of dengue.

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Section: Journal Of Applied Mathematicsmentioning

confidence: 99%

Section: Mathematical Model Constructionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Understanding Dengue Control for Short- and Long-Term Intervention with a Mathematical Model Approach

Bustamam

Aldila

Yuwanda

2018

Journal of Applied Mathematics

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“…Such a hypothesis is reasonable, because heavy road transport flows into the west of Santa Catarina from different regions of the country, particularly from regions with a high number of mosquito foci. In these regions, such as the Southeast and Central-West, the presence of the Ile mutation has been confirmed (Martins et al, 2009;Brito et al, 2013;Aguirre-Obando et al, 2016). In addition, the Southeast and Central-West regions have a direct influence on the dispersion of these mosquitoes to other regions (Julio et al, 2009).…”

Section: Resultsmentioning

confidence: 85%

Frequency of the Val1016Ile mutation on the kdr gene in Aedes aegypti (Diptera: Culicidae) in south Brazil

et al. 2016

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Recently, the number of Aedes aegypti foci has increased in west of Santa Catarina, south Brazil, which has increased concern regarding mosquito-borne disease outbreaks such as dengue fever, Zika virus, and chikungunya. Therefore, it is important to monitor genetic resistance to insecticides through "knockdown resistance". Homozygosity (Ile/Ile) at position 1016 in the coding region of a voltage-dependent sodium channel gene (Na) may induce resistance to pyrethroid insecticides. We evaluated the frequency of these alleles in A. aegypti in west Santa Catarina. In total, 349 specimens were obtained from the microregions of Joaçaba (31), Concórdia (35), Chapecó (154), and São Miguel do Oeste (129). We found that 109 individuals (31.0%) were homozygous for Val/Val, 102 (29.0%) were heterozygous for Val/Ile, and 138 (40.0%) were homozygous for Ile/Ile. The allele frequencies were similar for Val (0.455) and Ile (0.545). Joaçaba and Concórdia had the highest mutant allele frequencies (0.825 and 0.685, respectively). Therefore, these populations should be monitored for increases in pyrethroid resistance. The São Miguel do Oeste and Chapecó populations had similar frequencies of Val and Ile and were not in Hardy-Weinberg equilibrium, suggesting that a selection pressure or other evolutionary force has occurred. In conclusion, the observed frequency of Ile/Ile homozygous individuals in the region studied requires attention, because the implementation of controls using pyrethroid may increase the frequency of the mutant allele through the selection of resistant populations.

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“…Assim, com base na literatura científica, duas mutações estão fortemente relacionadas com resistência a piretróides em populações de Ae. aegypti: a substituição da Valina por Isoleucina, na posição 1016 da proteína (MARTINS et al, 2009;BATISTA, 2012;LINSS et al, 2014), e a substituição da Fenilalanina por Cisteína na posição 1534 (MARTINS et al, 2009;YANOLA et al, 2010LINSS et al, 2014AGUIRRE-OBANDO et al, 2016;SAINGASOOK et al, 2017) com Rockefeller, e semelhança com Campinas (z = 1,11; p = 0,11), sobretudo com Santos (z = 0,33; p = 0,71). Adicionalmente, estudos apontam que, assim como Campinas, altas taxas de suscetibilidade para o larvicida temefós (OP) são presentes na população de Marília (CHEDIAK et al, 2016;DIAS et al, 2017).…”

Section: Resultsunclassified

Avaliação da atividade locomotora de Aedes aegypti (Diptera: Culicidae) com diferentes perfis de resistência a inseticidas do Estado de São Paulo

Nakazato¹

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AGRADECIMENTOSAgradeço primeiramente a Deus por todas as bênçãos na minha vida.Agradeço à minha esposa e eterna companheira Lívia, por sempre estar ao meu lado, compartilhando momentos bons e também os desafios da vida. Agradeço por cada instante que se dedicou corrigindo algumas muitas versões do texto deste trabalho.Agradeço imensamente à minha família, em especial à minha mãe Regina e avó Ana, aos meus pais Marcelo e Edi, pelo apoio e pelos mais sábios conselhos que alguém poderia carinhosamente oferecer. E como são valiosos! Agradeço aos meus sogros Miriam e Roni, e aos meus cunhados Nádia e Talles por todo companheirismo e acolhimento que sempre tiveram comigo. Vocês são demais! Agradeço a minha orientadora Profa. Dra. Tamara Nunes de Lima Camara, por ter abraçado a ideia deste trabalho mesmo antes do meu ingresso na pós-graduação, além das inúmeras sugestões, ensinamentos, críticas que foram indispensáveis! Agradeço aos membros da banca prof. Dr. Lincoln Suesdek, Dra. Regiane Tironi e Dra. Márcia Bicudo, por todas observações e sugestões feitas na pré-banca que foram indispensáveis para melhor elucidação do meu trabalho, além de contribuírem para o meu amadurecimento acadêmico.Agradeço ao meu ex-orientador e grande amigo Dr. José Eduardo Bracco, por ter sido um grande divisor de águas no início da minha vida científica, principalmente por me ensinar a aprender. Muito obrigado! Agradeço pela equipe do Laboratório de Entomologia em Saúde Pública, em especial a Rosa Maria de Sá e ao prof. Dr. Paulo Urbinatti, por toda contribuição no meu trabalho, além da valiosa amizade. Aos alunos e companheiros de laboratório, , obrigado pelas altas doses de risadas, discussões, cumplicidade, que foram fundamentais para tornar as coisas e situações mais leves. Aos grandes amigos da faculdade, Mariana Dantas, Dra. Sandra Nagaki, Dra. Ivy Sá, MSc Leonardo Suveges, Dr. Fredy Galvis, MSc Vanessa Gusmão, MSc Amanda Camargo, MSc Cecília Lavitschka, Dra. Bruna Demari, prof. Dr. Delsio Natal, Dra. Márcia Bicudo, com quem tive a honra de conhecer e conviver, compartilhando momentos inesquecíveis, principalmente os incontáveis cafés na copa, muito obrigado! Agradeço as pesquisadoras da Sucen, Dra. Juliana Teles de Deus e Dra. Regiane Tironi, pela amizade e por sempre serem prestativas, seja para conversar ou mesmo para qualquer dúvida que eu pudesse ter. À PqC. Dra. Maria de Lourdes da Graça Macoris (Lula) e a toda equipe técnica da Sucen de Marília, SP, por terem cedido o material necessário para a execução dos experimentos e por terem acreditado neste trabalho.Agradeço ao CNPq pelo apoio financeiro quanto à bolsa oferecida. "A verdade é filha do tempo, e não da autoridade." (Galileu Galilei) RESUMO NAKAZATO, Bruno Magalhães. Avaliação da atividade locomotora de Aedes aegypti (Diptera: Culicidae) com diferentes perfis de resistência a inseticidas do Estado de São Paulo. 2018. 80 fl. Dissertação (Mestrado em Saúde Pública) -Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, 2018. Diversas populações de Aedes (Stegomyia...

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Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in Aedes aegypti populations from Jacarezinho (Brazil) after a Dengue Outbreak

Cited by 17 publications

References 49 publications

Understanding Dengue Control for Short- and Long-Term Intervention with a Mathematical Model Approach

Understanding Dengue Control for Short- and Long-Term Intervention with a Mathematical Model Approach

Frequency of the Val1016Ile mutation on the kdr gene in Aedes aegypti (Diptera: Culicidae) in south Brazil

Avaliação da atividade locomotora de Aedes aegypti (Diptera: Culicidae) com diferentes perfis de resistência a inseticidas do Estado de São Paulo

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