Contrasting patterns in in vitro fertilization pregnancy rates among fresh autologous, fresh oocyte donor, and cryopreserved cycles with the use of day 5 or day 6 blastocysts may reflect differences in embryo-endometrium synchrony

Shapiro, B.S.; Daneshmand, S.T.; Garner, Forest C.; Aguirre, M.; Ross, Richard

doi:10.1016/j.fertnstert.2006.08.092

Cited by 151 publications

(130 citation statements)

References 26 publications

Supporting

Mentioning

120

Contrasting

Unclassified

Order By: Relevance

“…Although cryopreservation may entail some risks to the embryo, FET may provide an endometrium with increased receptivity, as compared to that after ovarian stimulation. The timing of the Bwindow of implantation( WOI) in stimulated cycles is complicated by the fact that it may be advanced or delayed, and therefore easily mistimed [15][16][17][18][19][20][21][22]. Shapiro et al [23] showed that the clinical pregnancy rate per transfer is significantly greater in the cryopreservation group than in the fresh group in normal responders and concluded that the difference was due to impaired endometrial receptivity in fresh embryo transfer.…”

Section: Introductionmentioning

confidence: 99%

Optimal embryo transfer strategy in poor response may include freeze-all

Berkkanoğlu

Coetzee

Bulut

et al. 2016

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose In this retrospective cohort study, we investigated the best embryo transfer strategy in ICSI cycles with ≤4 oocytes collected at oocyte retrieval. Methods Women who underwent antagonist co-treatment COS for ICSI treatment between January 2010 and December 2015 at a private ART clinic (N = 2263). Eight hundred seventy-nine women (group 1) had ≤4 oocytes collected at oocyte retrieval, of whom 645 (group A) had cleavage stage embryo transfer (ET), and 234 (group B) had blastocyst ET. One thousand three hundred eighty-four women (group 2) had 10-15 oocytes collected at oocyte retrieval, of whom 676 (group C) had cleavage stage ET, and 708 women (group D) had blastocyst ET. Blastocyst vitrification was performed using the Cryotop method and FET using artificial cycles. Results In group 1, the cancellation rate was significantly lower in group A (25.2 vs 38 %). The pregnancy rate (PR), clinical PR, implantation rate (IR), and live birth rate (LBR) per ET and per oocyte retrieval were all lower in group A. The clinical PR, IR, and LBR per ET of vitrified-warmed blastocyst ET were significantly the highest. In group 2, the cycle cancellation rate was significantly lower in group C (3.5 vs 13.4 %). The PR, clinical PR, and IR per ET and per oocyte retrieval were all lower in group C. The LBR per ET was significantly lower, but the LBR per oocyte retrieval was not significantly lower in group C. Again, the PR, clinical PR, and IR per ET of vitrifiedwarmed blastocyst ET were significantly the highest. Conclusions Day 5 ET strategy has been reserved for normal or high responders. The improved pregnancy outcomes from blastocyst culture and cryopreservation may challenge ART to extend this benefit to poor responders.

show abstract

Section: Introductionmentioning

confidence: 99%

Optimal embryo transfer strategy in poor response may include freeze-all

Berkkanoğlu

Coetzee

Bulut

et al. 2016

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…Previous studies reported higher implantation and pregnancy rates with day 5 versus day 6 BET However; in all published studies, comparisons were made between blastocysts that were expanded by day 5 and transferred on the same day, and those who had shown one-day delay in expansion and postponed to be transferred on day 6 [11][12][13]. Therefore; it remains unclear whether this is due to embryonic factor, endometrial factor, or better synchronization between them.…”

Section: Introductionmentioning

confidence: 99%

Day 5 expanded blastocysts transferred on same day have comparable outcome to those left for more extended culture and transferred on day 6

Elgindy

Elsedeek

2012

J Assist Reprod Genet

View full text Add to dashboard Cite

Objective To study the outcome of blastocysts showing expansion on day 5 and transferred on day 5 or 6, in comparison with those unexpanded and transferred on day 6. Study Design Prospective cohort of 221 women prepared for BET classified into three groups according to timing of blastocyst expansion and day of embryo transfer. Group I; with expanded blastocysts on day 5 having day 5 transfer, group II; with expanded blastocysts on day 5 having day 6 transfer and group III ; with delayed expansion undergoing day 6 BET. Results Implantation rates, pregnancy rates, ongoing pregnancy rates, and live birth rates in the first 2 groups were almost double the rates in the third group. The figures for implantation rates were 40 % in the first two groups vs. 19 % in the third group (P<0.05). Pregnancy rates were 60.9 % and 64 % vs. 31.8 % (P<0.05) and ongoing pregnancy/ live-birth rates were 52.3 % & 56 % vs. 27.3 %. Conclusion The current study reports better implantation and pregnancy rates with earlier expanding blastocysts regardless of the time of transfer.

show abstract

“…Вероятной причиной возникновения описанных негативных эффектов могут явиться су-прафизиологические уровни стероидных гормонов в периоде, предшествующем имплантации эмбриона [22][23][24]. Рост эндометрия в цикле переноса крио-консервированного эмбриона более управляем, чем в цикле ИСО [25]. Считается, что «окно импланта-ции» эндометрия закрывается тем раньше, чем выше уровень эстрогенов (эндогенных или экзогенных), и тем самым снижает время для успешной импланта-ции бластоцисты, а в цикле ИСО уровень эстрогенов значительно выше за счет множественного роста фолликулов [26].…”

Section: Discussionunclassified

Comparative analysis of effectiveness of IVF cycles with fresh and frozen embryo transfer in patients of different age

Yakovenko¹,

Khryapenkova²,

Kirienko³

et al. 2016

Probl. reprod.

View full text Add to dashboard Cite

1 Клиника репродукции человека Альтравита ооо «ЭКо центр», москва, россия;2 Физический факультет московского государственного университета им. м.в. ломоносова, москва, россия Цель исследования -сравнить эффективность программ врт у пациенток разных возрастных групп при переносе эмбрионов в цикле иСо и криоконсервированных эмбрионов в криоцикле. Материал и методы. Проведен ретроспективный анализ 4832 программ врт, в ходе которого оценивались частота наступления беременности, частота прерывания беременности до 12 нед и частота прогрессирующей беременности. данные были исследованы у пациентов следующих возрастных групп: 20-34 года, 35-39 лет, 40-47 лет. результаты. Показано, что частота наступления клинической беременности была выше при переносе эмбриона в криоциклах, чем в циклах иСо во всех возрастных группах и составила 42,2 и 34,6% -у женщин 20-34 года, 32,3 и 27,9% -у женщин 35-39 лет, 20,3 и 15,8% -у женщин 40-47 лет. разница по этому показателю в криоцикле и цикле иСо составила от 4,4 до 7,6% в зависимости от возрастной группы, в пользу криоцикла. однако частота прерывания беременности до 12 нед в группе пациенток 20-34 года при переносе в криоцикле была значительно выше, чем при проведении ПЭ в цикле иСо и составила 32,2 и 20,9% соответственно. При оценке частоты прогрессирующих беременностей было показано, что в группе пациенток 20-34 года данный показатель в цикле иСо был значительно выше, чем в криоцикле, и составил 79,1% -в цикле иСо и 67,7% -в криоцикле. Выводы. Несмотря на более высокую частоту наступления клинической беременности, женщины до 35 лет имеют повышенный риск потери беременности до 12 нед после переноса эмбриона в криоцикле по сравнению с циклом иСо, поэтому при отсутствии противопоказаний у пациенток данной возрастной группы более предпочтительно делать ПЭ в цикле иСо. отсутствие различий в частоте прогрессирующей беременности после переноса эмбриона в криоцикле и цикле иСо в группе пациенток 35-39 лет позволяет лечащему врачу выбирать между ПЭ в цикле иСо и криопереносом в зависимости от клинической ситуации.

show abstract

Contrasting patterns in in vitro fertilization pregnancy rates among fresh autologous, fresh oocyte donor, and cryopreserved cycles with the use of day 5 or day 6 blastocysts may reflect differences in embryo-endometrium synchrony

Cited by 151 publications

References 26 publications

Optimal embryo transfer strategy in poor response may include freeze-all

Optimal embryo transfer strategy in poor response may include freeze-all

Day 5 expanded blastocysts transferred on same day have comparable outcome to those left for more extended culture and transferred on day 6

Comparative analysis of effectiveness of IVF cycles with fresh and frozen embryo transfer in patients of different age

Contact Info

Product

Resources

About