Contrasting Heating Patterns and Efficiency of the Prostatron and Targis Microwave Antennae for Thermal Treatment of Benign Prostatic Hyperplasia

Larson, Thayne R.; Blute, Michael L.; Tri, Jeffrey L.; Whitlock, Sidney V.

doi:10.1016/s0090-4295(98)00142-3

Cited by 26 publications

(11 citation statements)

References 28 publications

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“…Some clinical data on high-power treatment suggest that high power enhances improvement in voiding parameters with minor increases in morbidity (5,22). Other approaches to improving treatment are modified antenna design (23,24) and/or intraprostatic temperature monitoring during treatment for modulation of generator output (25). Thus, a series of measures has been introduced by a number of groups for refining and improving the treatment procedure.…”

Section: Discussionmentioning

confidence: 99%

Transurethral Microwave Thermotherapy in the Management of Lower Urinary Tract Symptoms from Benign Prostatic Obstruction: Follow-up after Five Years

Daehlin

Frugård

2000

Scandinavian Journal of Urology and Nephrology

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Section: Discussionmentioning

confidence: 99%

Transurethral Microwave Thermotherapy in the Management of Lower Urinary Tract Symptoms from Benign Prostatic Obstruction: Follow-up after Five Years

Daehlin

Frugård

2000

Scandinavian Journal of Urology and Nephrology

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“…Maintaining intralesional temperatures at .45°C while simultaneously keeping the surrounding temperatures ,45°C will cause coagulation necrosis in the targeted lesion while preserving the surrounding normal tissue. [70][71][72][73] Temperature correlation: At 40°C, cellular homeostasis is maintained; however, at 42°to 45°C (hyperthermia), cells become susceptible to damage. 74,75 However, even prolonged heating at these temperatures will not result in complete cell death in a given volume of tissue.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

“…85 To achieve high temperatures, the antenna must have minimal back heating and reflected power. 72,85,86 Monopole antennas (Prostatron) reflect 15% of their energy back to the antenna, so the energy absorbed by tissue is less; in contrast, a dipole antenna reflects only 1% of the energy. 86 In the present study, we used a dipole antenna.…”

mentioning

confidence: 99%

Needle-Based Ablation of Renal Parenchyma Using Microwave, Cryoablation, Impedance- and Temperature-Based Monopolar and Bipolar Radiofrequency, and Liquid and Gel Chemoablation: Laboratory Studies and Review of the Literature

Rehman

Landman

Lee

et al. 2004

Journal of Endourology

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"Needle-based ablation of renal parenchyma using microwave, cryoablation, impedance-and temperature-based monopolar and bipolar radiofrequency, and liquid and gel chemoablation: Laboratory studies and review of the literature." Journal of Endourology.18,1. 83-104. (2004 ABSTRACTBackground and Purpose: Small renal tumors are often serendipitously detected during the screening of patients for renal or other disease entities. Rather than perform a radical or partial nephrectomy for these diminutive lesions, several centers have begun to explore a variety of ablative energy sources that could be applied directly via a percutaneously placed needle-like probe. To evaluate the utility of such treatment for small renal tumors/masses, we compared the feasibility, regularity (consistency in size and shape), and reproducibility of necrosis produced in normal porcine kidneys by different modes of tissue ablation: microwaves, cold impedance-based and temperature-based radiofrequency (RF) energy (monopolar and bipolar), and chemical. Chemoablation was accomplished using ethanol gel, hypertonic saline gel, and acetic acid gel either alone or with simultaneous application of monopolar or bipolar RF energy. Materials and Methods: A total of 107 renal lesions were created laparoscopically in 33 domestic pigs. Microwave thermoablation (N 5 12) was done using a Targis T3 (Urologix) 10F antenna. Cryoablation (N 5 16) was done using a single 1.5-mm probe or three 17F microprobes (17F SeedNet™ system; Galil Medical) (N 5 10 single probe and N 5 6 three probes); a double freeze cycle with a passive thaw was employed under ultrasound guidance. Dry RF lesions were created using custom-made 18-gauge single-needle monopolar probe with two or three exposed metal tips (GelTx) (N 5 12) or a single-needle bipolar probe (N 5 6) at 50 W of 510 kHz RF energy for 5 minutes. In addition, a multitine RF probe (RITA Medical Systems) was used in one set of studies (N 5 6). Both impedance-and temperature-based RF were evaluated. Chemoablation was performed with 95% ethanol (4 mL), 24% hypertonic saline (4 mL), and 50% acetic acid (4 mL) as single injections. In addition, chemoablation was tested with monopolar and bipolar RF (wet RF). Tissues were harvested 1 week after ablation for light microscopy.Results: In 11 of the 15 ablation techniques, there was complete necrosis in all lesions; however, three ethanol gel lesions had skip areas, three hypertonic saline gel lesions showed no necrosis or injury, and one monopolar RF and one bipolar RF lesion showed skip areas. In contrast to impedance-based RF, heat-based RF (RITA) caused complete necrosis without skip areas. All cryolesions resulted in complete tissue necrosis, and cryotherapy was the only modality for which lesion size could be effectively monitored using ultrasound imaging.

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“…The dipole microwave antenna design of the Targis microwave system (Urologix, Minneapolis, Minn., USA) allows precise targeting of thermal energy [22]. Cooling capacity also varies among the models [23].…”

Section: The Concept Of Tumtmentioning

confidence: 99%

Transurethral microwave thermotherapy for treatment of benign prostatic hyperplasia

Waldert¹,

Djavan²

2004

The Journal of Men's Health & Gender

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Many urologists have a high regard for the usefulness of transurethral microwave therapy (TUMT) in treating patients with lower urinary tract symptoms caused by benign prostatic hyperplasia. This therapy has been examined clinically in many centers throughout the world. The rationale for its effect on symptoms is unlike many of the other so-called minimally invasive treatment modalities. The improvement in symptoms and voiding function is greater with transurethral microwave thermotherapy than with drug therapy, and the associated morbidity is low. It also offers greater versatility than drug therapy, allowing patients with severe baseline symptoms and small prostates to be treated successfully. In addition, there has been an evolution in the technology of TUMT from low-energy to high-energy application indicating that this technique has a future in the treatment of lower urinary tract symptoms.

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Contrasting Heating Patterns and Efficiency of the Prostatron and Targis Microwave Antennae for Thermal Treatment of Benign Prostatic Hyperplasia

Cited by 26 publications

References 28 publications

Transurethral Microwave Thermotherapy in the Management of Lower Urinary Tract Symptoms from Benign Prostatic Obstruction: Follow-up after Five Years

Transurethral Microwave Thermotherapy in the Management of Lower Urinary Tract Symptoms from Benign Prostatic Obstruction: Follow-up after Five Years

Needle-Based Ablation of Renal Parenchyma Using Microwave, Cryoablation, Impedance- and Temperature-Based Monopolar and Bipolar Radiofrequency, and Liquid and Gel Chemoablation: Laboratory Studies and Review of the Literature

Transurethral microwave thermotherapy for treatment of benign prostatic hyperplasia

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