“…Undoubtedly, among the many molecular targets of lithium, GSK3β may be in part responsible for its therapeutic effects, so the development of selective inhibitors of this kinase could influence the side effects of lithium. Although beyond the scope of this review, in recent years, the application of machine learning is accelerating the discovery of potential drugs with GSK3β inhibitory activity that can be repurposed as therapeutics for mood disorders and/or neurodegenerative disorders (see Kleandrova et al, 2020;Vignaux et al, 2020;Zhu et al, 2020;Reilley et al, 2021 for more details).…”