Contrasting Disease Progression, Microglia Reactivity, Tolerance, and Resistance to <em>Toxoplasma gondii</em> Infection in Two Mouse Strains
Daniel Guerreiro Diniz,
Jhonnathan Henrique Palheta de Oliveira,
Luma Cristina Ferreira Guerreiro
et al.
Abstract:Our study investigated the innate immune response to Toxoplasma gondii infection by assessing microglial phenotypic changes and sickness behavior as inflammatory response markers post-ocular tachyzoite instillation. Disease progression in Swiss albino mice was compared with documented outcomes in BALB/c mice using identical ocular route and parasite burden (2x105 tachyzoites), with saline as control. Contrary to expectations, Swiss albino mice displayed rapid, lethal disease progression, marked by pronounced s… Show more
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