Contrasting associations of maternal smoking and pre-pregnancy BMI with wheeze and eczema in children

Goudarzi, Houman; Konno, Satoshi; Kimura, Hirokazu; Araki, Atsuko; Miyashita, Chihiro; Itoh, Shinji; Bamai, Yu Ait; Kimura, Hironobu; Shimizu, Kaoruko; Suzuki, Masaru; Ito, Yoichi M.; Nishimura, Masaharu; Kishi, Reiko

doi:10.1016/j.scitotenv.2018.05.152

Cited by 30 publications

(46 citation statements)

References 49 publications

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“…Based on the titles or abstracts, 221 articles were excluded due to obvious reasons. After reviewing the full texts of remaining 63 articles, 41 articles were further excluded, leaving 22 articles that fulfilled predetermined eligibility criteria in this meta-analysis (4,7,8,(10)(11)(12)(13)(14)(15)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34). A flow diagram illustrating the exclusion of articles with specific reasons is shown in Figure 1.…”

Section: Qualified Studiesmentioning

confidence: 99%

“…Forno and colleagues in 2014 interrogated summary data from 14 studies, and found that pre-pregnancy maternal obesity was associated with the significant risk of both ever and current asthma or wheeze in children, and significance was only noticed for the association between high GWG and ever asthma or wheeze (9). Given the accumulating data afterwards (4,7,(10)(11)(12)(13)(14)(15), there is a need to reevaluate this association in a more comprehensive manner.…”

Section: Introductionmentioning

confidence: 99%

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Pre-pregnancy Maternal Weight and Gestational Weight Gain Increase the Risk for Childhood Asthma and Wheeze: An Updated Meta-Analysis

et al. 2020

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Background: Mounting evidence suggests that childhood asthma is closely associated with maternal weight before pregnancy and gestational weight gain (GWG), yet the results are not often reproducible. Objectives: We conducted a comprehensive meta-analysis, aiming to evaluate the association of pre-pregnancy maternal obesity or overweight and high GWG with the risk for childhood asthma and wheeze. Methods: Literature search, quality assessment, and data extraction were completed independently and in duplicate. Effect-size estimates are expressed as odds ratio (OR) with 95% confidence interval (CI). Results: Twenty-two observational studies involving 145,574 mother-child pairs were meta-analyzed. In overall analyses, maternal obesity or overweight in pre-pregnancy significantly increased the risk of both childhood asthma and wheeze (adjusted OR: 1.41 and 1.13, 95% CI: 1.26-1.59 and 1.07-1.20, both p < 0.001). Per 1 kg/m 2 increment in maternal body mass index was associated with a significantly increased risk of childhood asthma and wheeze (adjusted OR: 1.03, 95% CI: 1.02-1.03, p < 0.001). Compared with normal GWG, very high GWG (adjusted OR: 1.24, 95% CI: 1.04-1.47, p: 0.018), moderate high GWG (adjusted OR: 1.12, 95% CI: 1.04-1.21, p: 0.004), and very low GWG (adjusted OR: 1.26, 95% CI: 1.08-1.47, p: 0.004) increased the risk of childhood asthma and wheeze. There was a low probability of publication bias. Conclusions: Our findings indicate that both pre-pregnancy maternal obesity or overweight and very to moderate high or low GWG render their offspring susceptible to a significantly increased risk of having childhood asthma and wheeze.

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Section: Qualified Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pre-pregnancy Maternal Weight and Gestational Weight Gain Increase the Risk for Childhood Asthma and Wheeze: An Updated Meta-Analysis

et al. 2020

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“…5 One 2016 study conducted in Ontario found that 44% of toddlers suffered from food allergies, environmental allergies (wheezing, asthma, eczema or rhinitis), atopy or a combination thereof. 6 Though one cross-sectional and several longitudinal studies have assessed the early-life programming of allergic diseases by maternal weight or GWG, they have been limited by small sample sizes (<1000) 7 8 and self-reported measures of the exposure or outcome, [7][8][9][10][11][12][13][14][15][16][17][18][19] which have reduced their generalisability and validity. Further, most have focused on asthma alone, [7][8][9][10][11][12][13][14] none have examined anaphylaxis and none have calculated risk by the length of follow-up time, opting instead for aggregate rates (loglinear model), 8 13 17 odds (logistic model) 7 9-12 14- 16 18 or prevalence ratios (log-binomial model).…”

Section: What This Study Hopes To Add?mentioning

confidence: 99%

Examining the effects of pre-pregnancy weight and gestational weight gain on allergic disease development in offspring: a protocol for a population-based study using health administrative databases in Ontario, Canada

Srugo

Gaudet

Corsi

et al. 2021

bmjpo

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IntroductionOver the last 20 years, excess maternal pre-pregnancy weight (overweight and obesity) and gestational weight gain have become the most common morbidities in pregnancy. These morbidities may pose a threat to fetal immunological development through associated metabolic dysfunction and inflammation and, as such, may partly explain the concurrent rise of paediatric allergic disease. We will examine the effect of maternal pre-pregnancy weight and gestational weight gain during pregnancy on the incidence of allergic diseases among offspring in Canada’s most populous province.Methods and analysisWe will conduct a retrospective, population-based cohort study of all singleton live births to residents of Ontario, Canada in 2012–2013 and 2013–2014. The study population will be defined using maternal-newborn records from the provincial birth registry, which captures information on maternal pre-pregnancy weight and gestational weight gain. The cohort will be linked with provincial health administrative databases, allowing for follow-up of neonates through early childhood until 2019 (5–7 years of age). Allergic disease development (asthma, rhinitis, atopic dermatitis and anaphylaxis) will be ascertained using diagnostic codes from healthcare encounters. Potential confounders have been identified a priori through a directed acyclic graph. Cox proportional hazards regression models will be employed to assess the associations between maternal pre-pregnancy weight, gestational weight gain and incident paediatric allergic disease. Several preplanned sensitivity analyses will be conducted, including a probabilistic bias analysis of outcome misclassification.Ethics and disseminationEthics approval was obtained from the Research Ethics Board of the Children’s Hospital of Eastern Ontario and the ICES Privacy Office. Findings will be disseminated in scientific conference presentations and peer-reviewed publications.

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“…Twenty-one publications covering 24 studies were identified as relevant. 22 23 30-48 Six of the 24 studies assessed infant lung function (25%), [30][31][32][33][34][35] 15 assessed wheezing (62.5%) [38][39][40][41][42][43][44][45][46][47][48] (including two studies that assessed asthma and were reclassified as wheezing 22 23 ) and three assessed apnoea (15%). 36 37 Meta-analysis was performed for 13 wheezing studies (ten studies expressed the relationship between exposure and disease among the groups by OR and three by RR).…”

Section: Study Selectionmentioning

confidence: 99%

Association between active tobacco use during pregnancy and infant respiratory health: a systematic review and meta-analysis

et al. 2020

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ObjectiveTo evaluate what is known about active tobacco use during pregnancy and the association with infant respiratory health.DesignSystematic review and meta-analysis using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Data sourcesMEDLINE, EMBASE, Cochrane, CINAHL, and Maternity and Infant Care were searched thoroughly until June 2020.Eligibility criteria for selecting studiesWe included case–control and cohort studies estimating the association between active tobacco use during pregnancy and infant respiratory health (wheezing and apnoea) and lung function parameters in the first 12 months of life.Data extraction and synthesisExtraction and risk of bias assessment were conducted by two independent reviewers. The odds ratio, relative risk and mean differences were pooled with a 95% CI using the generic inverse variance method. Heterogeneity was assessed and expressed by percentage using I2.ResultsWe identified 4423 abstracts, and 21 publications met the eligibility criteria. Pooled OR showed an increase in wheezing episodes in infants born to mothers who were active tobacco users during pregnancy (OR 1.50, 95% CI 1.27 to 1.77, p<0.01). Mixed results were found on lung function parameters, and a meta-analysis including two studies with comparable methodology showed a trend towards reduced maximum flow rate at functional residual capacity of −34.59 mL/s (95% CI −72.81 to 3.63, p=0.08) in 1-month-old infants born to women who smoked during pregnancy. A higher risk of apnoea was described for infants born to mothers who used smokeless tobacco during pregnancy, while the results in infants born to women who actively smoked tobacco during pregnancy were non-conclusive.ConclusionInfants born to mothers who actively smoked during pregnancy are at higher odds of having wheeze and may have lower lung function. Smokeless tobacco use in pregnancy may increase the risk of apnoea in infancy.PROSPERO registration numberCRD42018083936.

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Contrasting associations of maternal smoking and pre-pregnancy BMI with wheeze and eczema in children

Cited by 30 publications

References 49 publications

Pre-pregnancy Maternal Weight and Gestational Weight Gain Increase the Risk for Childhood Asthma and Wheeze: An Updated Meta-Analysis

Pre-pregnancy Maternal Weight and Gestational Weight Gain Increase the Risk for Childhood Asthma and Wheeze: An Updated Meta-Analysis

Examining the effects of pre-pregnancy weight and gestational weight gain on allergic disease development in offspring: a protocol for a population-based study using health administrative databases in Ontario, Canada

Association between active tobacco use during pregnancy and infant respiratory health: a systematic review and meta-analysis

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