Contrast ultrasound LI-RADS LR-5 identifies hepatocellular carcinoma in cirrhosis in a multicenter restropective study of 1,006 nodules

Accuracy of the Liver Imaging Reporting and Data System in Computed Tomography and Magnetic Resonance Image Analysis of Hepatocellular Carcinoma or Overall Malignancy—A Systematic Review

“…We are aware of only 2 studies that include these data, and they apply a reference standard that includes findings at CT and MRI. 45,46 In conclusion, increasing numerical LI-RADS categories demonstrate a monotonically larger percentage of HCC and overall malignancy. Substantial variability and risk of bias indicate that high-quality trials and/or individual patient meta-analysis are needed.…”

Contrast-enhanced ultrasound of hepatocellular carcinoma: where do we stand?

“…CEUS LI-RADS is expected to improve the role of CEUS as a major imaging tool, as well as CT and MRI, and facilitate its incorporation into a multimodality imaging approach for liver studies in patients at risk for HCC [60]. The CEUS LI-RADS algorithm has been reported to be highly specific for HCC, while at the same time avoiding the misdiagnosis of ICC [61]. In particular, a study reported that CEUS showed high specificity (92.9%), but limited sensitivity (39.6%), in the diagnosis of HCC, thus suggesting that CEUS may play a role both in the characterization of nodules detected during surveillance and in a sequential combined approach after indeterminate CT or MRI studies [62].…”

Contrast-Enhanced Ultrasound Liver Imaging Reporting and Data System in Diagnosing Hepatocellular Carcinoma: Diagnostic Performance and Interobserver Agreement

“…The intention of CEUS-LI-RADS is twofold: to ensure maximum specificity for diagnosing HCC, and to improve the consistency of evaluation criteria. In cirrhotic patients, Terzi et al reported that CEUS-LI-RADS category 5 was highly specific for predicting HCC [10], which strongly influenced the recommendation from the European Association for the Study of the Liver (EASL) [11]. However, it should be noted that there is a higher etiologic prevalence of hepatitis B virus (HBV) infection in Asian HCC patients, whereas a higher prevalence of non-HBV liver diseases, such as hepatitis C virus (HCV) (64 %) or alcohol (10 %), was observed in the study population of Terzi et al [10].…”

“…In cirrhotic patients, Terzi et al reported that CEUS-LI-RADS category 5 was highly specific for predicting HCC [10], which strongly influenced the recommendation from the European Association for the Study of the Liver (EASL) [11]. However, it should be noted that there is a higher etiologic prevalence of hepatitis B virus (HBV) infection in Asian HCC patients, whereas a higher prevalence of non-HBV liver diseases, such as hepatitis C virus (HCV) (64 %) or alcohol (10 %), was observed in the study population of Terzi et al [10]. Whether these etiologic discrepancies between Asian and Western nations would affect the diagnostic performance of CEUS-LIRADS in predicting HCC is still unknown.…”