Contrast Sensitivity Is Associated With Chorioretinal Thickness and Vascular Density of Eyes in Simple Early-Stage High Myopia

Liu, Xinting; Wang, Yanli; Ying, Xiaoxiao; Zhang, Fen; Huang, Jing; Hang, Yu; Wang, Qian; Zheng, Miaoran; Hou, Fang; Lesmes, Luis Andres; Lü, Zhong-Lin; Liu, Fan; Mao, Xinjie

doi:10.3389/fmed.2022.847817

Cited by 9 publications

(6 citation statements)

References 42 publications

(52 reference statements)

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“…Zaben et al [31] reported a study to estimate the association between choroidal thickness in the macular area and retinal sensitivity in eyes with high myopia. And they found that retinal sensitivity in highly myopic eyes is directly correlated with choroidal thickness and does not seem to be associated with retinal thickness [10,[31][32] . All these findings are consistent with current study.…”

Section: Resultsmentioning

confidence: 99%

Optical coherence tomography enhanced depth imaging of chorioretinal folds in patients with orbital tumors

Peng¹,

Xue²,

Sodhi³

et al. 2023

Int J Ophthalmol

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AIM: To characterize spectral-domain optical coherence tomography (SD-OCT) features of chorioretinal folds in orbital mass imaged using enhanced depth imaging (EDI). METHODS: Prospective observational case-control study was conducted in 20 eyes of 20 patients, the uninvolved eye served as a control. All the patients underwent clinical fundus photography, computed tomography, EDI SD-OCT imaging before and after surgery. Two patients with cavernous hemangiomas underwent intratumoral injection of bleomycin A5; the remaining patients underwent tumor excision. Patients were followed 1 to 14mo following surgery (average follow up, 5.8mo). RESULTS: Visual acuity prior to surgery ranged from 20/20 to 20/200. Following surgery, 5 patients’ visual acuity remained unchanged while the remaining 15 patients had a mean letter improvement of 10 (range 4 to 26 letters). Photoreceptor inner/outer segment defects were found in 10 of 15 patients prior to surgery. Following surgical excision, photoreceptor inner/outer segment defects fully resolved in 8 of these 10 patients. CONCLUSION: Persistence of photoreceptor inner/outer segment defects caused by compression of the globe by an orbital mass can be associated with reduced visual prognosis. Our findings suggest that photoreceptor inner/outer segment defects on EDI SD-OCT could be an indicator for immediate surgical excision of an orbital mass causing choroidal compression.

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Section: Resultsmentioning

confidence: 99%

Optical coherence tomography enhanced depth imaging of chorioretinal folds in patients with orbital tumors

Peng¹,

Xue²,

Sodhi³

et al. 2023

Int J Ophthalmol

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“…Furthermore, we found that retinal vessel density could be related to CSF. Liu et al (15) also found the correlation between CSF and the changes of high myopia fundus. For high myopia, loss of contrast sensitivity at higher spatial frequencies was observed, which may be due to retinal function disturbances, which may occur at an early stage even before the onset of retinal pathological events (14).…”

Section: Influence Factors Odds Ratio (95% Ci) P-valuementioning

confidence: 87%

“…Previous studies have found that the visual quality decreases in patients with high myopia ( 14 ). We hypothesized that the reduced CSF in myopic patients is related to changes in fundus structure, and there are only a few studies that have discussed the correlation between visual quality and retinal vessel density in young myopes ( 11 , 15 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of macular vascular density on visual quality in young myopic adults

Wang

Xia

2022

Front. Med.

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ObjectiveTo evaluate macular vascular density using optical coherence tomography angiography (OCTA) and to investigate its impact on best-corrected visual acuity (BCVA), contrast sensitivity function (CSF), and higher-order aberrations (HOAs) in young myopic adults.MethodsThis cross-sectional study included 109 eyes with axial length (AL) between 22 and 26 mm in the medium AL group and 90 eyes with AL > 26 mm in the long AL group. OCTA was used to obtain 3 × 3 mm en face images, and the vessel length density (VLD), perfusion density (PD), and fovea avascular zone (FAZ) of the superficial layer were evaluated. Visual quality was assessed using the CSF and HOAs.ResultsSignificant differences were found in the inferior VLD, parafoveal PD, and FAZ areas between the groups. AL and macular vascular density showed negative correlations in the inferior and nasal areas. The spherical correction (SE) also showed a positive correlation with vascular density in these two areas. FAZ area and perimeter had a significant negative association with AL, and FAZ circularity was correlated with SE. CSF with bright around 6 and 12 spatial frequencies showed positive correlations with nasal PD. The parafoveal PD showed a significant correlation with BCVA after adjusting for other factors.ConclusionThe superficial macular vascular density of young myopic adults decreased with lower SE and longer AL in the parafovea area. An eye with a long AL has a smaller FAZ, and myopia decreases the FAZ circularity index. The decrease in vessel density could contribute to worse BCVA and may be correlated with lower CSF, but not with HOAs.

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“…Previous papers have reported that decreased CSF is correlated with retinal structural and microvascular alterations in patients with high myopia [ 30 ], diabetic retinopathy [ 9 ] and glaucoma [ 31 ]. To investigate the potential factors that may be associated with the CSF change in TAO patients, we also evaluated the retinal microvasculature and structure around the macula by OCTA.…”

Section: Discussionmentioning

confidence: 99%

Reduced contrast sensitivity function correlated with superficial retinal capillary plexus impairment in early stage of dysthyroid optic neuropathy

Jin

et al. 2023

Eye and Vis

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Background To assess the accuracy of contrast sensitivity function (CSF) in detecting dysthyroid optic neuropathy (DON) at an early stage in thyroid-associated ophthalmopathy (TAO) patients and to examine potential factors that may be linked to early visual impairments in these individuals. Methods A total of 81 TAO patients (50 non-DON and 31 DON), and 24 control subjects participated in the study. CSF was measured with the quick CSF (qCSF) method. Optical coherence tomography angiography (OCTA) images of the ganglion cell complex layer (GCCL), superficial and deep retinal capillary plexuses (SRCP and DRCP) in a 3 mm diameter area around the macula were evaluated. Results Compared with the controls, the area under the log contrast sensitivity function (AULCSF) and SRCP density were significantly reduced in non-DON and DON patients (all P < 0.05). The GCCL thickness of the DON patients was thinner than that of the controls and non-DON patients (all P < 0.05). The AULCSF was significantly correlated with spherical equivalent refractive error, muscle index, SRCP density and GCCL thickness in TAO patients, respectively (all P < 0.05). However, stepwise multi-regression analysis showed that the AULCSF was only significantly correlated with SRCP density (P < 0.001). Receiver operating characteristic curve analysis showed that the AULCSF produced the most accurate discrimination between non-DON and DON patients from the controls (AUC = 0.831, 0.987, respectively; all P < 0.001). Conclusions CSF change in the early stage of DON is related to SRCP density. It can be an early indicator of visual impairments associated with DON in TAO patients.

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Contrast Sensitivity Is Associated With Chorioretinal Thickness and Vascular Density of Eyes in Simple Early-Stage High Myopia

Cited by 9 publications

References 42 publications

Optical coherence tomography enhanced depth imaging of chorioretinal folds in patients with orbital tumors

Optical coherence tomography enhanced depth imaging of chorioretinal folds in patients with orbital tumors

Effect of macular vascular density on visual quality in young myopic adults

Reduced contrast sensitivity function correlated with superficial retinal capillary plexus impairment in early stage of dysthyroid optic neuropathy

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