Percutaneous epidural neuroplasty (PEN) is an effective interventional treatment for radicular pain. However, in some cases, contrast runoff to the spinal nerve root does not occur. We investigated whether contrast runoff to the spinal nerve root affects the success rate of PEN and whether additional transforaminal epidural blocks for intentional contrast runoff affect the success rate of PEN in cases in which contrast runoff is absent.This study was registered at ClinicalTrials.gov (Identifier: NCT03867630) in March 2019. We reviewed the medical records of 112 patients who underwent PEN with a wire-type catheter from May 2016 to August 2018. Patients were divided in 3 groups (Runoff group, Non-runoff group, Transforaminal group).Patients with low back pain and leg radicular pain who did not respond to lumbar epidural steroid injections PEN was performed in 112 patients with a wire-type catheter in target segment. We compared the success rate of PEN between(1) the Runoff group and the Non-runoff group,(2) the Runoff group and the Transforaminal group, and(3) the Non-runoff group and the Transforaminal group.The success rate was significantly different between the Runoff group and the Non-runoff group (P < .0007) and between the Nonrunoff group and the Transforaminal group (P = .0047), but not between the Runoff group and the Transforaminal group (P = .57).Contrast runoff influenced the success rate of PEN. In cases without contrast runoff, additional transforaminal epidural blocks for intentional contrast runoff increased the success rate of PEN with a wire-type catheter.Abbreviations: ODI = Oswestry disability index, PEN = percutaneous epidural neuroplasty, SD = standard deviation, VAS = visual analogue scale.