Background: Contrast-induced nephropathy CIN is an acute deterioration of renal function defined as the increase in serum creatinine by 25% above the baseline value within 48 h after administration of contrast agent, several risk factors may aggravate CIN and DM is a strong predisposing factor.
Objectives:To study the effect of contrast administration on renal function, and the relation of diabetes mellitus and other risk factors which can predispose patients to CIN in our local hospital.
Methods:Open-label, single center study. A total of 1117 patients underwent cardiac catheterization between January and December 2009, all patients with acute coronary syndrome, and stable CAD were included.Results: Among 1117 patients, the incidence of CIN was (4.9%) and this represents 55patients. Out of those 55 patients, 35 (64%) patients were diabetic, 39 (71%) patients were hypertensive, 38 (56%) patients under went diagnostic cardiac catheterization, 17 (34%) had PCI, 23 (41%) patients had body weight <70 kg, and 44 (80%) patients received omnipauqe contrast media.
Conclusion:The incidence of CIN was 4.9 %, and this concludes that hypertension and DM are the major risk factors in Saudi patients, diabetic patients in particular should be closely monitored for CIN and preventive measures should be strictly enforced. The Incidence of Contrast-Induced Nephropathy in Saudi Population after Cardiac Catheterization 2/4
CitationCopyright: ©2017 Balghith the time of enrollment. Two contrast media was used, Omnipaque and Visipaque Iohexol (Omnipaque) is a non-ionic, monomer, 350 mgI/ml with low osmolality of 884. The other contrast media was Iodixanol (Visipaque) which is a non-ionic,dimer, 320 mgI/ml with low osmolality of 290.
Definition of CINContrast-induced nephropathy was defined as a 25% increase in the creatinine value from the baseline reading in the 2 nd to 3 rd day post-cath.
Statistical analysisData were entered in Excel and analyzed using SPSS version 19.0 for Windows (SPSS, Chicago, IL, USA). Demographic characteristics are presented for continuous variables as means and standard deviations and categorical variables as frequencies and percentages. CIN and non-CIN patients were compared using the Chi-square test for categorical variables and Student's t-test for continuous variables. Significance was set at the 0.05 level.
ResultsA total of 1117 patients underwent coronary angiography. The mean age of the study cohort was 55.7 (±11.6), and 81.4 % were males. The incidence of CIN was (4.9%) and this represents 55patients ( Figure 1). The 1117 patients, underwent two types of procedures, 675 patients underwent diagnostic cath and 442 had PCI ( Figure 2). Furthermore, out of the 55 patients who developed CIN a 38 (56%) patient underwent diagnostic cardiac cath, 17 (34%) had PCI, and 23 (41%) patients had body weight <70 kg. In this study two types of contrast media were used, the number of patients who received Omipaquie contrast was 1012, and only 105 received visipuqe. Among the 55 patients who developed contra...