Contrast-Induced Nephropathy in Patients With ST Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention

Elbasan, Zafer; Şahin, Durmuş Yıldıray; Gür, Mustafa; Kuloğlu, Osman; Kivrak, Ali Sami; İçen, Yahya Kemal; Türkoğlu, Caner; Yıldırım, Arafat; Özdoğru, İbrahіm; Çaylı, Murat

doi:10.1177/0003319712463816

Cited by 32 publications

(45 citation statements)

References 40 publications

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“…Elevated SUA has been reported in literature as an independent predictor of CIN in STEMI patients who underwent primary PCI [15].…”

Section: Discussionmentioning

confidence: 93%

“…Hyperuricemia is characterized by inhibited nitric oxide system, activation of the local rennin-angiotensin system, pro-inflammatory and proliferative actions and enhanced synthesis of reactive oxygen species with increased oxidative stress and consequent renal dysfunction [15,16]. These effects of hyperuricemia should be more evident in patients with chronic kidney disease, in which there is a loss of nephron units with a poor residual renal function more vulnerable to external insults.…”

Section: Introductionmentioning

confidence: 99%

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Uric acid levels and the risk of Contrast Induced Nephropathy in patients undergoing coronary angiography or PCI

Barbieri¹,

Verdoia²,

Schaffer³

et al. 2015

Nutrition, Metabolism and Cardiovascular Diseases

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“…Elevated SUA has been reported in literature as an independent predictor of CIN in STEMI patients who underwent primary PCI [15].…”

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Uric acid levels and the risk of Contrast Induced Nephropathy in patients undergoing coronary angiography or PCI

Barbieri¹,

Verdoia²,

Schaffer³

et al. 2015

Nutrition, Metabolism and Cardiovascular Diseases

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“…Perhaps a novel scoring system combining these parameters and the CHA 2 DS 2 -VASc score may be more useful for prediction of CIN. In a study conducted with STEMI patients, the SYNTAX score was also useful for prediction of CIN [24]. However, SYNTAX is an angiographic scoring system.…”

Section: Discussionmentioning

confidence: 99%

CHA2DS2-VASc score predicts contrast-induced nephropathy in patients with ST-segment elevation myocardial infarction, who have undergone primary percutaneous coronary intervention

Çiçek¹,

Yıldırım²

2018

Kardiol Pol

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A b s t r a c t Background and aim:We aimed to investigate the predictive value of the CHA 2 DS 2 -VASc score in the development of contrast-induced nephropathy (CIN). Methods:A total of 2972 patients who had been diagnosed with ST elevation myocardial infarction (STEMI) and who had undergone primary coronary angioplasty were included in the study. The patients were divided into three groups according to the CHA 2 DS 2 -VASc score, i.e.: low risk (1 point), intermediate risk (2 points), and high risk (≥ 3 points). The groups were followed with regard to CIN development. Results:The median CHA 2 DS 2 -VASc score was significantly higher in the CIN(+) group compared to the CIN(-) group (3 vs. 2, p < 0.001). The rate of CIN was 3.32-fold higher (OR 3.32, 95% CI 1.98-5.55, p < 0.001) in the high-risk group (CHA 2 DS 2 -VASc ≥ 3) compared to the low-risk group (CHA 2 DS 2 -VASc = 1). Age (OR 1.25, 95% CI 1.14-1.36, p < 0.001), female gender (OR 1.52, 95% CI 1.23-1.89, p < 0.001), hypertension (OR 1.50, 95% CI 1.265-1.78, p < 0.001), peak creatinine kinase-MB (OR 1.15, 95% CI 1.10-1.21, p < 0.001), and the Killip score > 1 (OR 4.25, 95% CI 3.10-5.82, p < 0.001) were found to be independent predictors for CIN development. Conclusions:The CHA 2 DS 2 -VASc score is an independent and strong predictor of CIN development in patients with acute STEMI.

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“…Several studies explored the effect of serum uric acid (SUA) on CI-AKI among high-risk patients such as STEMI undergoing primary PCI. Elbasan et al showed that SUA was associated with CI-AKI in STEMI patients undergoing pPCI (mean SUA=6.2±0.9 mg/dL, 95% CI, 1.877-3.236; p=0.002)[15]. In another study, Mendi MA et al…”

mentioning

confidence: 93%

“…In addition, only a limited number of studies reported that hyperuricemia was an independent predictor of CI-AKI in STEMI patients undergoing pPCI. Moreover, it was uncertain about the role of uric acid in the long-term outcome [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

The relationship between Hyperuricemia and Contrast-induced acute kidney injury undergoing primary percutaneous coronary intervention: the protocol of secondary analysis for ATTEMPT RESCIND-1 study

Guo

Song

Chen

et al. 2019

Preprint

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Background: Contrast-induced acute kidney injury (CI-AKI) contributes toward unfavorable clinical outcomes after primary percutaneous coronary intervention (pPCI). We assessed whether hyperuricemia is an independent predictor of CI-AKI and outcomes in patients undergoing pPCI. Methods/design: Our study was a secondary analysis for the database from ATTEMPT study, enrolling 560 ST-segment elevation myocardial infarction (STEMI) patients undergoing pPCI. Eligible patients received peri-procedural either via aggressive (left ventricular end-diastolic pressure guided) or routine (<=500ml) intravenous hydration with the isotonic solution (0.9% NaCl) with randomization. The primary endpoint was CI-AKI, defined as >25% or 0.5 mg/dL increase in serum creatinine from baseline during the first 48-72 hours post-procedurally. Patients were divided into 2 groups according to the admission serum uric acid (SUA) level. Hyperuricemia was defined as a SUA level >7 mg/dL (417 mmol/L) in males and >6 mg/dL (357 mmol/L) in females. Multivariate analyses for CI-AKI and long-term mortality were performed using the logistic regression and Cox regression analyses, respectively. Discussion: This study will determine the predictive value of hyperuricemia for the development of CI-AKI and outcomes in patients with STEMI undergoing pPCI. We predict that hyperuricemia will be associated with a risk of CI-AKI in patients with pPCI. Furthermore, after adjusting for other variables, long-term mortality after pPCI was higher in those with hyperuricemia than in those with normouricemia. Results of this study may provide scientific evidence for the effect of hyperuricemia on CI-AKI and long-term outcomes, thereby offering the potential possibility of lowering SUA on the development of CI-AKI and outcomes.

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Contrast-Induced Nephropathy in Patients With ST Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention

Cited by 32 publications

References 40 publications

Uric acid levels and the risk of Contrast Induced Nephropathy in patients undergoing coronary angiography or PCI

Uric acid levels and the risk of Contrast Induced Nephropathy in patients undergoing coronary angiography or PCI

CHA2DS2-VASc score predicts contrast-induced nephropathy in patients with ST-segment elevation myocardial infarction, who have undergone primary percutaneous coronary intervention

The relationship between Hyperuricemia and Contrast-induced acute kidney injury undergoing primary percutaneous coronary intervention: the protocol of secondary analysis for ATTEMPT RESCIND-1 study

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