Contrast Enhancement without Transient Map Expansion for Species-Specific Vocalizations in Core Auditory Cortex during Learning

Shepard, Kathryn N.; Chong, Kelly K.; Liu, Robert C.

doi:10.1523/eneuro.0318-16.2016

Cited by 30 publications

(39 citation statements)

References 66 publications

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“…Plastic changes in the maternal brain include (but are not limited to) increased reliability of neuronal responses to USVs 10 , 11 , 13 , 32 , 44 . Despite these changes, many other physiological parameters remain stable like the tonotopic representation of the cortical sheet and single unit responses to pure tones 12 , 45 . Our blind recordings and recordings from non-TRAPed cells across groups and conditions (which presumably represent a random sample of cortical neurons) provide further support to the general notion of cortical stability with respect to pure tones in mothers.…”

Section: Discussionmentioning

confidence: 99%

Genetic tagging of active neurons in auditory cortex reveals maternal plasticity of coding ultrasonic vocalizations

et al. 2018

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Cortical neurons are often functionally heterogeneous even for molecularly defined subtypes. In sensory cortices, physiological responses to natural stimuli can be sparse and vary widely even for neighboring neurons. It is thus difficult to parse out circuits that encode specific stimuli for further experimentation. Here, we report the development of a Cre-reporter mouse that allows recombination for cellular labeling and genetic manipulation, and use it with an activity-dependent Fos-CreERT2 driver to identify functionally active circuits in the auditory cortex. In vivo targeted patch recordings validate our method for neurons responding to physiologically relevant natural sounds such as pup wriggling calls and ultrasonic vocalizations (USVs). Using this system to investigate cortical responses in postpartum mothers, we find a transient recruitment of neurons highly responsive to USVs. This subpopulation of neurons has distinct physiological properties that improve the coding efficiency for pup USV calls, implicating it as a unique signature in parental plasticity.

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Section: Discussionmentioning

confidence: 99%

Genetic tagging of active neurons in auditory cortex reveals maternal plasticity of coding ultrasonic vocalizations

et al. 2018

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“…1B ) is observed in weaned dams (Liu and Schreiner, 2007), although a recent study reported that single-cell responses to pup calls in dams disappear at 10 days post-weaning (Tasaka et al, 2018). In the auditory cortex of lactating, as well as weaned (up to three weeks) dams, an increase in the neuronal responses to pup calls in ultrasound-responding regions, while a decrease in responses in areas which respond to low frequency sounds is observed (Shepard et al, 2016). This is paralleled by a decrease in the spontaneous activity of single neurons in weaned dams (Galindo-Leon et al, 2009; Lin et al,2013).…”

Section: Plasticity In the Auditory Cortex During Motherhoodmentioning

confidence: 99%

“…Among other changes, long-lasting plasticity in somatosensory (Rosselet et al, 2006; Xerri et al, 1994) and auditory (Cohen et al, 2011; Cohen and Mizrahi, 2015; Liu et al, 2006; Liu and Schreiner, 2007; Marlin et al, 2015; Shepard et al, 2016; Tasaka et al, 2018) cortex have recently been shown to contribute to increased responsiveness to infant cues. Most of these studies have been performed in rodents, amenable to techniques for selective monitoring and manipulation of single cells and networks in vivo.…”

Section: Introductionmentioning

confidence: 99%

Neuromodulation of maternal circuits by oxytocin

Valtcheva

Froemke

2018

Cell Tissue Res

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Motherhood in mammals involves tremendous changes throughout the body and central nervous system, which support attention and nurturing of infants. Maternal care consists of complex behaviors, such as nursing and protection of the offspring, requiring new mothers to become highly sensitive to infant needs. Long-lasting neural plasticity in various regions of the cerebral cortex may enable the perception and recognition of infant cues, important for appropriate caregiving responses. Recent findings have demonstrated that the neuropeptide oxytocin is involved in a number of physiological processes, including parturition and lactation and dynamically shaping neuronal responses to infant stimuli as well. Here, we review experience-dependent changes within the cortex occurring throughout motherhood, focusing on plasticity of the somatosensory and auditory cortex. We outline the role of oxytocin in gating cortical plasticity and discuss potential mechanisms regulating oxytocin release in response to different sensory stimuli.

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“…Recent optical imaging studies have indicated that the auditory cortex of the mouse brain is composed of at least four tonotopic subfields (Issa et al, 2014) that were tentatively annotated as the dorsomedial field (DM), anterior auditory field (AAF), primary auditory cortex (A1), and secondary auditory field (A2) in a previous report (Tsukano et al, 2017). Subregions in the mouse auditory cortex may be functionally specialized (Honma et al, 2013;Baba et al, 2016;Shepard et al, 2016), and so connective patterns with other brain regions may vary according to subregion. To date, several neuronal tracing investigations have examined the afferents and efferents to/from the mouse auditory cortex.…”

Section: Introductionmentioning

confidence: 97%

Reciprocal connectivity between secondary auditory cortical field and amygdala in mice

Tsukano

Hou

Horie

et al. 2019

Preprint

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Recent studies have examined the feedback pathway from the amygdala to the auditory cortex in conjunction with the feedforward pathway from the auditory cortex to the amygdala. However, these connections have not been fully characterized. Here, to visualize the comprehensive connectivity between the auditory cortex and amygdala, we injected cholera toxin subunit b (CTB), a bidirectional tracer, into multiple subfields in the mouse auditory cortex after identifying the location of these subfields using flavoprotein fluorescence imaging. After injecting CTB into the secondary auditory field (A2), we found densely innervated CTB-positive axon terminals that were mainly located in the lateral amygdala (La), and slight innervations in other divisions such as the basal amygdala. Moreover, we found a large number of retrogradely-stained CTB-positive neurons in La after injecting CTB into A2. When injecting CTB into the primary auditory cortex (A1), a small number of CTB-positive neurons and axons were visualized in the amygdala. Finally, we found a near complete absence of connections between the other auditory cortical fields and the amygdala. These data suggest that reciprocal connections between A2 and La are main conduits for communication between the auditory cortex and amygdala in mice.

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Contrast Enhancement without Transient Map Expansion for Species-Specific Vocalizations in Core Auditory Cortex during Learning

Abstract: Visual Abstract

Cited by 30 publications

References 66 publications

Genetic tagging of active neurons in auditory cortex reveals maternal plasticity of coding ultrasonic vocalizations

Genetic tagging of active neurons in auditory cortex reveals maternal plasticity of coding ultrasonic vocalizations

Neuromodulation of maternal circuits by oxytocin

Reciprocal connectivity between secondary auditory cortical field and amygdala in mice

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