Contrast enhancement of the gastrointestinal tract on MR images using intravenous gadolinium-DTPA

Mirowitz, Scott A.

doi:10.1007/bf00198104

Cited by 21 publications

(2 citation statements)

References 21 publications

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“…Although only infrequently used in the past, MR imaging has benefitted from the availability of breath-hold gradient-recalled-echo and breath-hold half-Fourier rapid acquisition with relaxation enhancement (RARE) sequences (12)(13)(14)(15)(16)(17)(18)(19). However, problems related to small-bowel distention and to functional information remain limitations of MR imaging of the small bowel.…”

mentioning

confidence: 99%

Small-Bowel Disease: Comparison of MR Enteroclysis Images with Conventional Enteroclysis and Surgical Findings

Umschaden

Szolar²,

Gasser³

et al. 2000

Radiology

262

131

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mentioning

confidence: 99%

Small-Bowel Disease: Comparison of MR Enteroclysis Images with Conventional Enteroclysis and Surgical Findings

Umschaden

Szolar²,

Gasser³

et al. 2000

Radiology

262

131

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“…With relative inexperience in this area and the lack of controls, the significance of rectal wall enhancement in our patients was difficult to interpret. Intravenous gadolinium results show some degree of bowel wall enhancement even in subjects without gastrointestinal disease (20).…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging to Distinguish the Type and Severity of Pediatric Inflammatory Bowel Diseases

Durno,

Sherman,

Williams

et al. 2000

J. pediatr. gastroenterol. nutr.

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Background:The distinction between ulcerative colitis and Crohn's disease is important, because treatment options and clinical course may vary. Magnetic resonance imaging (MRI) allows noninvasive transmural assessment of the intestine and may facilitate differentiation of ulcerative colitis from Crohn's disease. The objective of this prospective study was to determine whether MRI differentiates Crohn's disease from ulcerative colitis in children as effectively as colonoscopy with mucosal biopsies.Methods:Fifteen patients underwent colonoscopy with biopsies followed by abdominal MRI. The MRI diagnosis, determined by two radiologists independently completing a standardized form was compared with the gastroenterologic diagnosis.Results:After colonoscopy and review of histology, Crohn's disease was diagnosed in nine patients, ulcerative colitis in five, and indeterminate colitis in one, who was excluded from study. Agreement of the MRI diagnosis with the gastroenterologic diagnosis was 4 of 4 (100%) for ulcerative colitis, 4 of 10 (40%) for Crohn's disease considering both radiologists, and 5 of 10 (50%) for Crohn's disease for each radiologist individually. Percentage of enhancement by MRI did not correlate with the severity of inflammation determined at endoscopy among the patients with Crohn's disease (r = −0.3, P = 0.366). There was agreement on severity of inflammation in three of four patients with ulcerative colitis.Conclusions:Current MRI interpretation of inflammatory bowel disease did not adequately recognize Crohn's disease in children. Therefore, colonoscopy with biopsy remains the most accurate tool for determining the type and severity of inflammatory bowel disease in children and adolescents.

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Gadolinium zeolite as an oral contrast agent for magnetic resonance imaging

Young¹,

Fan²,

Rubin³

et al. 1995

Magnetic Resonance Imaging

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The purpose of this study was to evaluate efficacy and safety of a gadolinium (Gd) zeolite suspension as an oral MRI contrast agent. Serial dilutions of GADO-LITE Oral Suspension 1,2-300 micrograms of Gd(III)/mL) were prepared. MRI (T1 and T2 weighted) of standards and dogs (precontrast and postcontrast) were performed. Toxicity and Gd absorption were also assessed. Subsequently, 30 normal male adult volunteers were divided into six groups of five subjects each. Gd zeolite po suspension was administered before and after MRI in volumes and concentrations ranging from 250 to 1500 mL; 6 to 60 micrograms of Gd+3/mL. The images were rated (efficacy score) by a blinded reader. Vital signs, blood chemistries and urinalysis were recorded. Gadolite Oral Suspension produced excellent enhancement of the dog gastrointestinal (GI) tract. No toxicity or absorption of Gd was observed in dogs receiving doses up to 4 times the anticipated human dose daily for 14 consecutive days. In clinical trials, Gd zeolite significantly improved the efficacy scores for all groups and all pulsing sequences (all P values < .05). Efficacy scores and signal intensities generally increased with concentration and volume. No Gd was detected in blood or urine specimens. No significant adverse events were reported. Gd zeolite is a promising contrast medium for enhancement of the GI tract in MRI.

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Contrast enhancement of the gastrointestinal tract on MR images using intravenous gadolinium-DTPA

Cited by 21 publications

References 21 publications

Small-Bowel Disease: Comparison of MR Enteroclysis Images with Conventional Enteroclysis and Surgical Findings

Small-Bowel Disease: Comparison of MR Enteroclysis Images with Conventional Enteroclysis and Surgical Findings

Magnetic Resonance Imaging to Distinguish the Type and Severity of Pediatric Inflammatory Bowel Diseases

Gadolinium zeolite as an oral contrast agent for magnetic resonance imaging

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