Contrast-Enhanced Whole-Heart Coronary MRA using Gadofosveset

Prompona, Maria; Cyran, Clemens C.; Nikolaou, Konstantin; Bauner, Kerstin; Reiser, Maximilian; Huber, Armin

doi:10.1016/j.acra.2010.02.009

Cited by 11 publications

(9 citation statements)

References 35 publications

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“…This study of coronary MRA at 3.0T was designed as an intra-individual comparison between gadofosveset trisodium, an intravascular contrast agent, and gadobenate dimeglumine, an extracellular chelate. In summary, gadofosveset had superior image quality and CNR compared with gadobenate for coronary MRA at 3T, corroborating with results seen in similar studies [19, 20]. Despite showing improvements, CNR between the coronary arteries and the myocardium was still not significantly greater for gadofosveset over gadobenate.…”

Section: Discussionsupporting

confidence: 87%

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3.0-T whole-heart coronary magnetic resonance angiography: comparison of gadobenate dimeglumine and gadofosveset trisodium

Raman

Nacif

Cater

et al. 2013

Int J Cardiovasc Imaging

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Objective Gadolinium enhanced coronary magnetic resonance angiography (MRA) at 3 Tesla appears to be superior to non-contrast methods. Gadofosveset is an intravascular contrast agent that may be well suited to this application. The purpose of this study was to perform an intra-individual comparison of gadofosveset and gadobenate for coronary MRA at 3 Tesla. Materials and Methods In this prospective randomized study, 22 study subjects [8 (36%) male; 27.9 ± 6 years; BMI = 22.8 ± 2 Kg/m2] underwent two studies using a contrast-enhanced inversion recovery three-dimensional fast low angle shot MRA at 3 Tesla. The order of contrast agent administration was varied randomly, separated by an average of 30 ± 5 days, using either gadobenate dimeglumine (Gd-BOPTA; Bracco, 0.1 mmol/Kg) or gadofosveset trisodium (MS-325; Lantheus Med, 0.03 mmol/Kg). Acquisition time, signal-to-noise ratio (SNR) of coronary vessels and contrast-to-noise ratio (CNR) were evaluated. Results Of 308 coronary arteries and veins segment analyzed, overall SNR of coronary arteries and veins segments were not different for the two contrast agents (132 ± 79 for gadofosveset vs 135 ± 78 for gadobenate, p=0.69). Coronary artery CNR was greater for gadofosveset in comparison to gadobenate (73.5 ± 46.9vs. 59.3 ± 75.7 respectively, p=0.03). Gadofosveset-enhanced MRA images displayed better image quality than gadobenate-enhanced MRA images (2.77 ± 0.61 for gadofosveset vs. 2.11 ± 0.51, P<.001). Inter- and intra-reader variability was excellent (ICC > 0.90) for both contrast agents. Conclusion Gadofosveset trisodium appears to show slightly better performance for coronary MRA at 3T compared to gadobenate.

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Section: Discussionsupporting

confidence: 87%

“…Nephrogenic systemic fibrosis (NSF) has been associated with gadolinium-based contrast agents in patients with renal dysfunction [19, 30]. Metabolic acidosis, caused by disassociation of free Gd 3+ ions, is known to be a significant cause of renal failure and NSF [31].…”

Section: Discussionmentioning

confidence: 99%

3.0-T whole-heart coronary magnetic resonance angiography: comparison of gadobenate dimeglumine and gadofosveset trisodium

Raman

Nacif

Cater

et al. 2013

Int J Cardiovasc Imaging

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“…Recently, 3T MRI has also been made available in the clinical setting (15). A field strength of 3T offers a higher signal-to-noise ratio and contrast-to-noise ratio than 1.5T, which improves the image quality (31). Therefore, 3T MRI may achieve better diagnostic performance than 1.5T MRI.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Performance of Coronary CT Angiography, Stress Dual-Energy CT Perfusion, and Stress Perfusion Single-Photon Emission Computed Tomography for Coronary Artery Disease: Comparison with Combined Invasive Coronary Angiography and Stress Perfusion Cardiac MRI

Chung

Hwang

et al. 2017

Korean J Radiol

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ObjectiveTo investigate the diagnostic performance of coronary computed tomography angiography (CCTA), stress dual-energy computed tomography perfusion (DE-CTP), stress perfusion single-photon emission computed tomography (SPECT), and the combinations of CCTA with myocardial perfusion imaging (CCTA + DE-CTP and CCTA + SPECT) for identifying coronary artery stenosis that causes myocardial hypoperfusion. Combined invasive coronary angiography (ICA) and stress perfusion cardiac magnetic resonance (SP-CMR) imaging are used as the reference standard.Materials and MethodsWe retrospectively reviewed the records of 25 patients with suspected coronary artery disease, who underwent CCTA, DE-CTP, SPECT, SP-CMR, and ICA. The reference standard was defined as ≥ 50% stenosis by ICA, with a corresponding myocardial hypoperfusion on SP-CMR.ResultsFor per-vascular territory analysis, the sensitivities of CCTA, DE-CTP, SPECT, CCTA + DE-CTP, and CCTA + SPECT were 96, 96, 68, 93, and 68%, respectively, and specificities were 72, 75, 89, 85, and 94%, respectively. The areas under the receiver operating characteristic curve (AUCs) were 0.84 ± 0.05, 0.85 ± 0.05, 0.79 ± 0.06, 0.89 ± 0.04, and 0.81 ± 0.06, respectively. For per-patient analysis, the sensitivities of CCTA, DE-CTP, SPECT, CCTA + DE-CTP, and CCTA + SPECT were 100, 100, 89, 100, and 83%, respectively; the specificities were 14, 43, 57, 43, and 57%, respectively; and the AUCs were 0.57 ± 0.13, 0.71 ± 0.11, 0.73 ± 0.11, 0.71 ± 0.11, and 0.70 ± 0.11, respectively.ConclusionThe combination of CCTA and DE-CTP enhances specificity without a loss of sensitivity for detecting hemodynamically significant coronary artery stenosis, as defined by combined ICA and SP-CMR.

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“…The agent reversibly binds to albumin, yielding a higher relaxivity as well as prolonged blood pool residence [7]. Initial work exploring the use of this agent for cardiac imaging was focused on the adult population [8–11] with promising results. More recently, evaluation in children has focused on enhancing bright blood balanced steady state imaging, also with promising results [12].…”

Section: Introductionmentioning

confidence: 99%

Combined respiratory and cardiac triggering improves blood pool contrast-enhanced pediatric cardiovascular MRI

et al. 2011

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Background Contrast-enhanced cardiac MRA suffers from cardiac motion artifacts and often requires a breath-hold. Objective This work develops and evaluates a blood pool contrast agent enhanced combined respiratory and ECG triggered MRA method. Materials and methods An SPGR sequence was modified to enable combined cardiac and respiratory triggering on a 1.5T scanner. 23 consecutive patients referred for pediatric heart disease receiving gadofosveset were recruited in HIPAA-compliant fashion with IRB approval and informed consent/assent. Patients underwent standard, non-triggered contrast-enhanced MRA with or without suspended respiration. Additionally, a free-breathing triggered MRA was acquired. Triggered and non-triggered studies were presented in blinded random order independently to two radiologists twice. Anatomic structure delineation was graded for each triggered and non-triggered acquisition and the visual quality on triggered MRA was compared directly to non-triggered MRA. Results Triggered images received higher scores from each radiologist for all anatomic structures on each of the two reading sessions (Wilcoxon rank-sum test, p< 0.05). In direct comparison, triggered images were preferred over non-triggered images for delineating cardiac structures, with most comparisons reaching statistical significance (binomial test, p<0.05). Conclusion Combined cardiac and respiratory triggering, enabled by a blood-pool contrast agent, improves delineation of most anatomic structures in pediatric cardiovascular MRA.

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Contrast-Enhanced Whole-Heart Coronary MRA using Gadofosveset

Cited by 11 publications

References 35 publications

3.0-T whole-heart coronary magnetic resonance angiography: comparison of gadobenate dimeglumine and gadofosveset trisodium

3.0-T whole-heart coronary magnetic resonance angiography: comparison of gadobenate dimeglumine and gadofosveset trisodium

Diagnostic Performance of Coronary CT Angiography, Stress Dual-Energy CT Perfusion, and Stress Perfusion Single-Photon Emission Computed Tomography for Coronary Artery Disease: Comparison with Combined Invasive Coronary Angiography and Stress Perfusion Cardiac MRI

Combined respiratory and cardiac triggering improves blood pool contrast-enhanced pediatric cardiovascular MRI

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