Contrast-Enhanced Ultrasound of the Liver: Optimizing Technique and Clinical Applications

Pang, Emily; Chan, Adrienne S.; Ho, Stephen; Harris, Alison

doi:10.2214/ajr.17.17843

Cited by 44 publications

(28 citation statements)

References 86 publications

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“…SonoVue® (Bracco SpA, Milan, Italy) is the most commonly adopted CA in Europe and recently, has also been approved for hepatic perfusion imaging in adults and pediatric patients by the FDA in 2016 [9, 10]. Definity®/Luminity® (Lantheus Medical, Billerica, MA, USA) is commonly used in the US but has also recently been licensed in Canada and Australia [9, 10]. Sonazoid TM (Daiichi-Sankyo, GE, Tokyo, Japan) is mostly used in Japan and South Korea [9, 10].…”

Section: Dynamic Contrast-enhanced Ultrasoundmentioning

confidence: 99%

“…Definity®/Luminity® (Lantheus Medical, Billerica, MA, USA) is commonly used in the US but has also recently been licensed in Canada and Australia [9, 10]. Sonazoid TM (Daiichi-Sankyo, GE, Tokyo, Japan) is mostly used in Japan and South Korea [9, 10]. It contains a hydrogenated egg phosphatidylserine on its outer shell which is phagocytosed by Kupffer cells of the liver while maintaining its echogenicity; this not only enables observation of hepatic perfusion but also the Kupffer cells [10].…”

Section: Dynamic Contrast-enhanced Ultrasoundmentioning

confidence: 99%

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Intraoperative Imaging Techniques to Visualize Hepatic (Micro)Perfusion: An Overview

Shen

Milstein

et al. 2020

Eur Surg Res

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The microcirculation plays a crucial role in the distribution of perfusion to organs. Studies have shown that microcirculatory dysfunction is an independent predictor of morbidity and mortality. Hence, assessment of liver perfusion offers valuable information on the (patho)physiological state of the liver. The current review explores techniques in perfusion imaging that can be used intraoperatively. Available modalities include dynamic contrast-enhanced ultrasound, handheld vital microscopes, indocyanine green fluorescence angiography, and laser contrast speckle imaging. Dynamic contrast-enhanced ultrasound relays information on deep tissue perfusion and is a commonly used technique to assess tumor perfusion. Handheld vital microscopes provide direct visualization of the sinusoidal architectural structure of the liver, which is a unique feature of this technique. Intraoperative fluorescence imaging uses indocyanine green, a dye that is administered intravenously to visualize microvascular perfusion when excited using near-infrared light. Laser speckle contrast imaging produces non-contact large surface-based tissue perfusion imaging free from movement-or pressure-related artefacts. In this review, we discuss the intrinsic advantages and disadvantages of these techniques and their clinical and/or scientific applications.

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Section: Dynamic Contrast-enhanced Ultrasoundmentioning

confidence: 99%

Section: Dynamic Contrast-enhanced Ultrasoundmentioning

confidence: 99%

Intraoperative Imaging Techniques to Visualize Hepatic (Micro)Perfusion: An Overview

Shen

Milstein

et al. 2020

Eur Surg Res

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“…Several brands are approved by the Food and Drug Administration in the United States, and they utilize similar microbubble technology. Of the agents approved, contrast with a sulfur hexafluoride core (Lumason ® , Bracco Diagnostics Inc., Monroe Township, NJ, USA) is widely used in the United States, Europe, and China [13] and at our own institution. CEUS has several unique features in comparison with CT or MRI with contrast.…”

Section: Introductionmentioning

confidence: 99%

“…CEUS has several unique features in comparison with CT or MRI with contrast. The contrast agent used with US is made of microbubbles that are smaller than a red blood cell, so that they do not cross the endothelium but instead remain in the intravascular space [13,14]. The microbubbles burst after several minutes of imaging, with byproducts exhaled through the pulmonary system [13].…”

Section: Introductionmentioning

confidence: 99%

Contrast-Enhanced Ultrasonography for Screening and Diagnosis of Hepatocellular Carcinoma: A Case Series and Review of the Literature

et al. 2020

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Background: Contrast-enhanced ultrasound (CEUS) is a safe and noninvasive imaging technique that can characterize and evaluate liver lesions, and has been approved for this use in the Unites States since 2016. CEUS has been shown to be similar in accuracy to computed tomography (CT) and magnetic resonance imaging (MRI) for noninvasive diagnosis of hepatocellular carcinoma (HCC) and offers several advantages in certain patient populations who have contraindications for CT or MRI. However, CEUS has inherent limitations and has not been widely employed for evaluation of HCC. Methods: We present three retrospective cases of liver lesions in patients with cirrhosis, who underwent screening for HCC using concurrent, well-timed CT and CEUS. Results: In these cases, the liver lesions were better visualized and then diagnosed as malignancy via CEUS, whereas the lesions were best appreciated on CT only in retrospect. Conclusions: In some cirrhotic patients, a focal lesion may be more easily identifiable via CEUS than on CT and thus accurately characterized, suggesting an important and complementary role of CEUS with CT or MRI. Further studies are indicated to support the use of CEUS for the diagnosis and characterization of liver lesions in screening patients at risk for developing HCC.

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“…The main methods to assess both liver quality and the pathological changes include ultrasound, positron emission tomography (PET), magnetic resonance imaging (MRI), computed tomography (CT), biochemical blood analysis, morphological and immunohistochemical analysis of biopsy specimens, and clearance tests using indocyanine, as well as various radioactive isotopes. [1][2][3] Ultrasound, PET, MRI, and CT are quite informative, but they only provide information about the liver tissue at the level of the *Address all correspondence to Daria Kuznetsova, E-mail: daria.s.kuznetsova@gmail.com whole organ, not allowing resolution at a cellular level. Biochemical blood analysis is among the simplest methods for studying liver function.…”

Section: Introductionmentioning

confidence: 99%

Metabolic imaging and secondary ion mass spectrometry to define the structure and function of liver with acute and chronic pathology

et al. 2019

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Conventional techniques are insufficient precisely to describe the internal structure, the heterogeneous cell populations, and the dynamics of biological processes occurring in diseased liver during surgery. There is a need for a rapid and safe method for the successful diagnosis of liver disease in order to plan surgery and to help avoid postoperative liver failure. We analyze the progression of both acute (cholestasis) and chronic (fibrosis) liver pathology using multiphoton microscopy with fluorescence lifetime imaging and second-harmonic generation modes combined with time-of-flight secondary ion mass spectrometry chemical analysis to obtain new data about pathological changes to hepatocytes at the cellular and molecular levels. All of these techniques allow the study of cellular metabolism, lipid composition, and collagen structure without staining the biological materials or the incorporation of fluorescent or other markers, enabling the use of these methods in a clinical situation. The combination of multiphoton microscopy and mass spectrometry provides more complete information about the liver structure and function than could be assessed using either method individually. The data can be used both to obtain new criteria for the identification of hepatic pathology and to develop a rapid technique for liver quality analysis in order to plan surgery and to help avoid postoperative liver failure in clinic. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Contrast-Enhanced Ultrasound of the Liver: Optimizing Technique and Clinical Applications

Cited by 44 publications

References 86 publications

Intraoperative Imaging Techniques to Visualize Hepatic (Micro)Perfusion: An Overview

Intraoperative Imaging Techniques to Visualize Hepatic (Micro)Perfusion: An Overview

Contrast-Enhanced Ultrasonography for Screening and Diagnosis of Hepatocellular Carcinoma: A Case Series and Review of the Literature

Metabolic imaging and secondary ion mass spectrometry to define the structure and function of liver with acute and chronic pathology

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