Contrast-Enhanced Ultrasound in the Differential Diagnosis of Exocrine Versus Neuroendocrine Pancreatic Tumors

Serra, Carla; Felicani, Cristina; Mazzotta, Elena; Piscitelli, L; Cipollini, Maria Luigia; Tomassetti, Paola; Pezzilli, Raffaele; Casadei, Riccardo; Morselli-Labate, Antonio Maria; Stanghellini, Vincenzo; Corinaldesi, Roberto; Giorgio, Roberto De

doi:10.1097/mpa.0b013e31827a7b01

Cited by 33 publications

(14 citation statements)

References 49 publications

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“…In the present study, the accuracy of CEUS in characterizing hyperenhancing lesions was 72.8%, similar to the one published by Serra et al [23] -73.8%; but slightly lower than in the PAMUS, in which the accuracy was 90.5% [3]. This might be due to the small number of hyperenhancing lesions identified by CE-CT/MRI (28 cases) and also because we couldn't verify the imaging results with a more sensitive method (pathology).…”

Section: Discussionsupporting

confidence: 79%

The value of Contrast-Enhanced Ultrasound in the characterization of vascular pattern of solid pancreatic lesions

et al. 2015

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The aim of our study was to evaluate the accuracy of CEUS in the characterization of pancreatic solid lesions, considering cross sectional imaging techniques (CE-CT/MRI) as the "gold standard" methods. Material and methods: We performed a retrospective, monocentric study that included 91 solid pancreatic lesions which were evaluated by CEUS and by a secondline contrast imaging technique (CT or MRI), considered as the reference method. Results: The rate of a conclusive diagnosis based on a typical enhancement pattern was 94% (78/83 cases). In 72 cases out of 83 (86.7%) there was a perfect concordance between CEUS and the "gold-standard" imaging method (CE-CT/MRI). In our study, 88% (73/83) of the pancreatic lesions were categorized as malignant due to their typical wash-out aspect in the late phase. The overall accuracy of CEUS for the differential diagnosis of solid pancreatic tumors was approximately 81%. The accuracy of CEUS for the diagnosis of hypoenhancing pancreatic tumors was approximately 89.1%; while for the diagnosis of hyperenhancing pancreatic tumors it was approximately 72.8%. Conclusion: CEUS allows the differentiation between hypo-vs. hyperenhancing pancreatic solid lesions, with a considerable diagnostic accuracy, a fundamental step in the precise diagnosis of pancreatic tumors.

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Section: Discussionsupporting

confidence: 79%

The value of Contrast-Enhanced Ultrasound in the characterization of vascular pattern of solid pancreatic lesions

et al. 2015

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“…Although relatively new for the pancreatic evaluation, CEUS represents a safe and feasible technique to immediately better characterize and stage the disease during single US examination [33]. Our review found few studies investigating the vascular pattern of pathologically proven pancreatic tumors and enrolling more than 100 patients [1, 11,12,15,20,26,28]. However, during the last ten years we observed a progressive increase in published papers regarding CEUS of the pancreas.…”

Section: Methodological Qualitymentioning

confidence: 76%

Diagnostic Performance of Contrast-Enhanced Ultrasound (CEUS) and Contrast-Enhanced Endoscopic Ultrasound (ECEUS) for the Differentiation of Pancreatic Lesions: A Systematic Review and Meta-Analysis

et al. 2014

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The sensitivity, specificity, and DOR results show the high value of CEUS for the characterization and differentiation of ductal adenocarinomas from other pancreatic diseases and for cystic pancreatic lesions. For this reason and due to their noninvasive nature, CEUS and ECEUS should be used as the first methods for characterizing neoplastic pancreatic lesions, especially since these are often incidental findings. The methods improve the quality of ultrasound diagnostics and result in faster diagnosis and better disease management.

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“…In the Pancreatic Multicenter Ultrasound Study (PAMUS) meta-analysis, a high accuracy of CEUS in characterizing pancreatic masses was reported, as solid pancreatic lesions were correctly characterized in respect to pathology with an accuracy of 91.7% and pancreatic ductal adenocarcinoma was correctly characterized with an accuracy of 87.8% [70]. In the literature, a specificity close to 100% for transabdominal CEUS diagnosis of ductal adenocarcinoma, with a sensitivity of 90%, has been reported [71,72]. Recently, a metaanalysis was conducted with the aim of evaluating the role of CEUS in differentiating among pancreatic lesions.…”

Section: Pancreasmentioning

confidence: 99%

Clinical use of contrast-enhanced ultrasound beyond the liver: a focus on renal, splenic, and pancreatic applications

et al. 2019

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Contrast-enhanced ultrasound (CEUS) is a relatively novel, but increasingly used, diagnostic imaging modality. In recent years, due to its safety, quickness, and repeatability, several studies have demonstrated the accuracy, specificity, and sensitivity of CEUS. The European Federation of Societies for Ultrasound in Medicine and Biology has recently updated the previous guidelines from 2012 for the use of CEUS in non-hepatic applications. This review deals with the clinical use and applications of CEUS for the evaluation of non-hepatic abdominal organs, focusing on renal, splenic, and pancreatic applications.

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Contrast-Enhanced Ultrasound in the Differential Diagnosis of Exocrine Versus Neuroendocrine Pancreatic Tumors

Abstract: Contrast-enhanced ultrasound has a valuable diagnostic accuracy in differentiating exocrine from endocrine pancreatic tumors, which is a fundamental step to address appropriate histological evaluation, therapeutic approach, and follow-up.

Cited by 33 publications

References 49 publications

The value of Contrast-Enhanced Ultrasound in the characterization of vascular pattern of solid pancreatic lesions

The value of Contrast-Enhanced Ultrasound in the characterization of vascular pattern of solid pancreatic lesions

Diagnostic Performance of Contrast-Enhanced Ultrasound (CEUS) and Contrast-Enhanced Endoscopic Ultrasound (ECEUS) for the Differentiation of Pancreatic Lesions: A Systematic Review and Meta-Analysis

Clinical use of contrast-enhanced ultrasound beyond the liver: a focus on renal, splenic, and pancreatic applications

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